Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models

Thallmair, Sebastian; Ingólfsson, Helgi I.; Marrink, Siewert J.

doi:10.1021/acs.jpclett.8b01877

Title: Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models

Journal Article · Fri Sep 07 00:00:00 EDT 2018 · Journal of Physical Chemistry Letters

DOI:https://doi.org/10.1021/acs.jpclett.8b01877· OSTI ID:1488792

^[1];

^[2]; Marrink, Siewert J. ^[1]

Univ. of Groningen, Groningen (Netherlands). Groningen Biomolecular Sciences and Biotechnology Inst. and The Zernike Inst. for Advanced Material
Univ. of Groningen, Groningen (Netherlands). Groningen Biomolecular Sciences and Biotechnology Inst. and The Zernike Inst. for Advanced Material; Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Biosciences and Biotechnology Division, Physical and Life Sciences Directorate

The plasma membrane is a highly complex multicomponent system that is central to the functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes the formation of nanodomains. These nanodomains are often correlated across the two membrane leaflets, but the underlying physical mechanism remains unclear. Using coarse-grained molecular dynamics simulations, we investigate the influence of cholesterol flip-flop on membrane properties, in particular, the interleaflet coupling of cholesterol-enriched domains. We show that the cholesterol density correlation between the leaflets of an average mammalian plasma membrane is significantly reduced by suppressing interleaflet cholesterol population. Our results suggest an amplifying role of cholesterol in signal transduction across the leaflets.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); Univ. of Groningen, Groningen (Netherlands). Faculty of Mathematics and Natural Sciences

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1488792

Alternate ID(s):: OSTI ID: 1508623

Report Number(s):: LLNL-JRNL-751356; 937164

Journal Information:: Journal of Physical Chemistry Letters, Vol. 9, Issue 18; ISSN 1948-7185

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 27 works

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