Engineering of large-pore lipid-coated mesoporous silica nanoparticles for dual cargo delivery to cancer cells

Noureddine, Achraf; Hjelvik, Elizabeth A.; Croissant, Jonas G.; Durfee, Paul N.; Agola, Jacob O.; Brinker, C. Jeffrey

doi:10.1007/s10971-018-4772-1

Title: Engineering of large-pore lipid-coated mesoporous silica nanoparticles for dual cargo delivery to cancer cells

Journal Article · Fri Aug 17 00:00:00 EDT 2018 · Journal of Sol-Gel Science and Technology

DOI:https://doi.org/10.1007/s10971-018-4772-1· OSTI ID:1474081

Noureddine, Achraf ^[1]; Hjelvik, Elizabeth A. ^[1]; Croissant, Jonas G. ^[1]; Durfee, Paul N. ^[1]; Agola, Jacob O. ^[1]; Brinker, C. Jeffrey ^[2]

Univ. of New Mexico, Albuquerque, NM (United States). Chemical and Biological Engineering
Univ. of New Mexico, Albuquerque, NM (United States). Chemical and Biological Engineering. Center for Micro-Engineered Materials. Advanced Materials Lab.; Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Lipid-coated mesoporous silica nanoparticles (LC-MSNs) have recently emerged as a next-generation cargo delivery nanosystem combining the unique attributes of both the organic and inorganic components. The high surface area biodegradable inorganic mesoporous silica core can accommodate multiple classes of bio-relevant cargos in large amounts, while the supported lipid bilayer coating retains the cargo and increases the stability of the nanocarrier in bio-relevant media which should promote greater bio-accumulation of LC-MSNs in cancer sites. In this paper, we report on the optimization of various sol–gel synthesis (pH, stirring speed) and post-synthesis (hydrothermal treatment) procedures to enlarge the MSN pore size and tune the surface chemistry so as to enable loading and delivery of large biomolecules. Finally, the proof of concept of the dual cargo-loaded nanocarrier has been demonstrated in immortalized cervical cancer HeLa cells using MSNs of various fine-tuned pore sizes.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Univ. of New Mexico, Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); SNL Laboratory Directed Research and Development (LDRD) Program; Leukemia & Lymphoma Society (LLS) (United States)

Grant/Contract Number:: NA0003525

OSTI ID:: 1474081

Report Number(s):: SAND-2018-10253J; 667988

Journal Information:: Journal of Sol-Gel Science and Technology, Vol. 89; ISSN 0928-0707

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 4 works

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Title: Engineering of large-pore lipid-coated mesoporous silica nanoparticles for dual cargo delivery to cancer cells

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