Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

Technical Report · Fri Sep 21 00:00:00 EDT 2018

DOI:https://doi.org/10.2172/1473773· OSTI ID:1473773

Erickson, Keesha E. ^[1]; Rukhlenko, Oleksii S. ^[1]; Shahinuzzaman, Md. ^[2]; Slavkova, Kalina P. ^[1]; Lin, Yen Ting ^[1]; Stites, Edward C. ^[3]; Anghel, Marian ^[1]; Posner, Richard G. ^[4]; Barua, Dipak ^[5]; Kholodenko, Boris N. ^[5]; Hlavacek, William S. ^[1]

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1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2. Univ. of Missouri Science and Technology, Rolla, MO (United States)
3. The Salk Institute for Biological Studies, La Jolla, CA (United States)
4. Northern Arizona Univ., Flagstaff, AZ (United States)
5. Univ. College Dublin, Dublin (Ireland)

Receptor tyrosine kinases (RTKs) typically contain multiple autophosphorylation sites in their cytoplasmic domains. Once activated, these autophosphorylation sites can recruit downstream signaling proteins containing Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains, which recognize phosphotyrosine-containing short linear motifs (SLiMs).

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE Laboratory Directed Research and Development (LDRD) Program
• DOE Contract Number: AC52-06NA25396
• OSTI ID: 1473773
• Report Number(s): LA-UR-18-29001
• Country of Publication: United States
• Language: English

Related Subjects

Biological Science