Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography

Naha, Pratap C.; Lau, Kristen C.; Hsu, Jessica C.; Hajfathalian, Maryam; Mian, Shaameen; Chhour, Peter; Uppuluri, Lahari; McDonald, Elizabeth S.; Maidment, Andrew D.  A.; Cormode, David P.

doi:10.1039/c6nr02618d

Title: Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography

Journal Article · Wed Jun 29 00:00:00 EDT 2016 · Nanoscale

DOI:https://doi.org/10.1039/c6nr02618d· OSTI ID:1467020

Naha, Pratap C. ^[1]; Lau, Kristen C. ^[1]; Hsu, Jessica C. ^[2]; Hajfathalian, Maryam ^[3]; Mian, Shaameen ^[4]; Chhour, Peter ^[2]; Uppuluri, Lahari ^[1]; McDonald, Elizabeth S. ^[1]; Maidment, Andrew D. A. ^[1]; Cormode, David P. ^[5]

Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Radiology
Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Radiology and Dept. of Bioengineering
Temple Univ., Philadelphia, PA (United States). Dept. of Mechanical Engineering
Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Bioengineering
Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Radiology, Dept. of Bioengineering and Dept. of Cardiology

Earlier detection of breast cancer reduces mortality from this disease. Thus, the development of better screening techniques is a topic of intense interest. Contrast-enhanced dual-energy mammography (DEM) is a novel technique that has improved sensitivity for cancer detection. However, the development of contrast agents for this technique is in its infancy. We herein report gold-silver alloy nanoparticles (GSAN) that have potent DEM contrast properties and improved biocompatibility. GSAN formulations containing a range of gold:silver ratios and capped with m-PEG were synthesized and characterized using various analytical methods. DEM and computed tomography (CT) phantom imaging showed that GSAN produced robust contrast that was comparable to silver alone. Cell viability, reactive oxygen species generation and DNA damage results revealed that the formulations with 30% or higher gold content are cytocompatible to Hep G2 and J774A.1 cells. In vivo imaging was performed in mice with and without breast tumors. The results showed that GSAN produce strong DEM and CT contrast and accumulated in tumors. Furthermore, both in vivo imaging and ex vivo analysis indicated the excretion of GSAN via both urine and feces. In summary, GSAN produce strong DEM and CT contrast, and has potential for both blood pool imaging and for breast cancer screening.

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Research Organization:: Univ. of Pennsylvania, Philadelphia, PA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH); Susan G. Komen Foundation; The Roentgen Fund

Contributing Organization:: Hologic, Inc., Marlborough, MA (United States)

Grant/Contract Number:: SC0012476; R00 EB012165; R03-CA171661; R01 HL131557; UL1TR000003; UL1RR024134; AC140060

OSTI ID:: 1467020

Journal Information:: Nanoscale, Vol. 8, Issue 28; ISSN 2040-3364

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 67 works

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62 RADIOLOGY AND NUCLEAR MEDICINE
gold nanoparticles
silver nanoparticles
dual-energy mammography
computed tomography
contrast agents
breast cancer screening

Title: Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography

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