A carbon nanotube reporter of microRNA hybridization events in vivo

Harvey, Jackson D.; Jena, Prakrit V.; Baker, Hanan A.; Zerze, Gül H.; Williams, Ryan M.; Galassi, Thomas V.; Roxbury, Daniel; Mittal, Jeetain; Heller, Daniel A.

doi:10.1038/s41551-017-0041

Title: A carbon nanotube reporter of microRNA hybridization events in vivo

Journal Article · Mon Mar 13 00:00:00 EDT 2017 · Nature Biomedical Engineering (Online)

DOI:https://doi.org/10.1038/s41551-017-0041· OSTI ID:1462350

Harvey, Jackson D. ^[1]; Jena, Prakrit V. ^[2]; Baker, Hanan A. ^[1]; Zerze, Gül H. ^[3]; Williams, Ryan M. ^[2]; Galassi, Thomas V. ^[1]; Roxbury, Daniel ^[4]; Mittal, Jeetain ^[3]; Heller, Daniel A. ^[1]

Memorial Sloan Kettering Cancer Center, New York City, NY (United States). Molecular Pharmacology Program; Weill Cornell Medical College, New York City, NY (United States). Dept. of Pharmacology
Memorial Sloan Kettering Cancer Center, New York City, NY (United States). Molecular Pharmacology Program
Lehigh Univ., Bethlehem, PA (United States). Dept. of Chemical and Biomolecular Engineering
Univ. of Rhode Island, Kingston, RI (United States). Dept. of Chemical Engineering

MicroRNAs and other small oligonucleotides in biofluids are promising disease biomarkers, yet conventional assays require complex processing steps that are unsuitable for point-of-care testing or for implantable or wearable sensors. Single-walled carbon nanotubes are an ideal material for implantable sensors, owing to their emission in the near-infrared spectral region, photostability and exquisite sensitivity. Here, we report an engineered carbon-nanotube-based sensor capable of real-time optical quantification of hybridization events of microRNA and other oligonucleotides. The mechanism of the sensor arises from competitive effects between displacement of both oligonucleotide charge groups and water from the nanotube surface, which result in a solvatochromism-like response. The sensor, which allows for detection via single-molecule sensor elements and for multiplexing by using multiple nanotube chiralities, can monitor toehold-based strand-displacement events, which reverse the sensor response and regenerate the sensor complex. We also show that the sensor functions in whole urine and serum, and can non-invasively measure DNA and microRNA after implantation in live mice.

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Research Organization:: Lehigh Univ., Bethlehem, PA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Materials Sciences & Engineering Division; National Institutes of Health (NIH); National Science Foundation (NSF); Ovarian Cancer Research Fund Alliance (OCRFA); American Cancer Society (ACS)

Contributing Organization:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

Grant/Contract Number:: SC0013979; DP2-HD075698; P30-CA008748; TG-MCB-120014; AC02-05CH11231; 2T32CA062948-21; T32GM007739; 370463

OSTI ID:: 1462350

Alternate ID(s):: OSTI ID: 1490254

Journal Information:: Nature Biomedical Engineering (Online), Vol. 1, Issue 4; ISSN 2157-846X

Country of Publication:: United States

Language:: English

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Cited by: 108 works

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