Routine Production of 89Zr Using an Automated Module

Wooten, A.; Madrid, Evelyn; Schweitzer, Gordon; Lawrence, Luke; Mebrahtu, Efrem; Lewis, Benjamin; Lapi, Suzanne

doi:10.3390/app3030593

Title: Routine Production of ⁸⁹Zr Using an Automated Module

Journal Article · Fri Jul 12 00:00:00 EDT 2013 · Applied Sciences

DOI:https://doi.org/10.3390/app3030593· OSTI ID:1454864

Wooten, A. ^[1]; Madrid, Evelyn ^[2]; Schweitzer, Gordon ^[2]; Lawrence, Luke ^[2]; Mebrahtu, Efrem ^[2]; Lewis, Benjamin ^[3]; Lapi, Suzanne ^[1]

Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology. Dept. of Biomedical Engineering
Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology
Washington Univ., St. Louis, MO (United States). School of Medicine. Mallinckrodt Inst. of Radiology. Dept. of Physics

⁸⁹Zr has emerged as a useful radioisotope for targeted molecular imaging via positron emission tomography (PET) in both animal models and humans. This isotope is particularly attractive for cancer research because its half-life (t_1/2 = 3.27 days) is well-suited for in vivo targeting of macromolecules and nanoparticles to cell surface antigens expressed by cancer cells. Furthermore, ⁸⁹Zr emits a low-energy positron (E_β+,mean = 0.40 MeV), which is favorable for high spatial resolution in PET, with an adequate branching ratio for positron emission (BR = 23%). The demand for ⁸⁹Zr for research purposes is increasing; however, ⁸⁹Zr also emits significant gamma radiation (Γ_{15 keV} = 6.6 R∙cm²/mCi∙h), which makes producing large amounts of this isotope by hand unrealistic from a radiation safety standpoint. Fortunately, a straightforward method exists for production of ⁸⁹Zr by bombarding a natural Y target in a biomedical cyclotron and then separation of ⁸⁹Zr from the target material by column chromatography. The chemical separation in this method lends itself to remote processing using an automated module placed inside a hot cell. In this work, we have designed, built and commissioned a module that has performed the chemical separation of ⁸⁹Zr safely and routinely, at activities in excess of 50 mCi, with radionuclidic purity > 99.9% and satisfactory effective specific activity (ESA).

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Research Organization:: Washington Univ., St. Louis, MO (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Nuclear Physics (NP); National Inst. of Health (NIH) (United States)

Grant/Contract Number:: NA0000979; SC0008657; T32EB014855-01

OSTI ID:: 1454864

Journal Information:: Applied Sciences, Vol. 3, Issue 3; ISSN 2076-3417

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 36 works

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[89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer Laforest, Richard; Lapi, Suzanne E.; Oyama, Reiko Molecular Imaging and Biology, Vol. 18, Issue 6 https://doi.org/10.1007/s11307-016-0951-z	journal	May 2016
Targeting HER2 in Nuclear Medicine for Imaging and Therapy Massicano, Adriana V. F.; Marquez-Nostra, Bernadette V.; Lapi, Suzanne E. Molecular Imaging, Vol. 17 https://doi.org/10.1177/1536012117745386	journal	January 2018
Comparative Study with 89Y-foil and 89Y-pressed Targets for the Production of 89Zr † Alnahwi, Aiman; Tremblay, Sébastien; Guérin, Brigitte Applied Sciences, Vol. 8, Issue 9 https://doi.org/10.3390/app8091579	journal	September 2018
Medical Cyclotron Solid Target Preparation by Ultrathick Film Magnetron Sputtering Deposition Skliarova, Hanna; Cisternino, Sara; Cicoria, Gianfranco Instruments, Vol. 3, Issue 1 https://doi.org/10.3390/instruments3010021	journal	March 2019
Evaluation of ⁸⁹Zr-pertuzumab in Breast Cancer Xenografts Marquez, Bernadette V.; Ikotun, Oluwatayo F.; Zheleznyak, Alexander Molecular Pharmaceutics, Vol. 11, Issue 11 https://doi.org/10.1021/mp500323d	journal	August 2014
Zirconium-89 Labeled Antibodies: A New Tool for Molecular Imaging in Cancer Patients van de Watering, Floor C. J.; Rijpkema, Mark; Perk, Lars BioMed Research International, Vol. 2014 https://doi.org/10.1155/2014/203601	journal	January 2014
Development of 89Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications Lange, Sara E. S.; Zheleznyak, Alex; Studer, Matthew Oncotarget, Vol. 7, Issue 11 https://doi.org/10.18632/oncotarget.7552	journal	February 2016
Microfluidic Preparation of a ⁸⁹ Zr-Labeled Trastuzumab Single-Patient Dose Wright, Brian D.; Whittenberg, Joseph; Desai, Amit Journal of Nuclear Medicine, Vol. 57, Issue 5 https://doi.org/10.2967/jnumed.115.166140	journal	January 2016
Recent Advances in Zirconium-89 Chelator Development Bhatt, Nikunj; Pandya, Darpan; Wadas, Thaddeus Molecules, Vol. 23, Issue 3 https://doi.org/10.3390/molecules23030638	journal	March 2018

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07 ISOTOPE AND RADIATION SOURCES
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Title: Routine Production of 89Zr Using an Automated Module

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Title: Routine Production of ⁸⁹Zr Using an Automated Module