Ionic liquid-tolerant microorganisms and microbial communities for lignocellulose conversion to bioproducts

Yu, Chaowei; Simmons, Blake A.; Singer, Steven W.; Thelen, Michael P.; VanderGheynst, Jean S.

doi:10.1007/s00253-016-7955-0

Title: Ionic liquid-tolerant microorganisms and microbial communities for lignocellulose conversion to bioproducts

Journal Article · Sat Nov 12 00:00:00 EST 2016 · Applied Microbiology and Biotechnology

DOI:https://doi.org/10.1007/s00253-016-7955-0· OSTI ID:1436606

Yu, Chaowei ^[1]; Simmons, Blake A. ^[2]; Singer, Steven W. ^[2]; Thelen, Michael P. ^[3]; VanderGheynst, Jean S. ^[4]

Univ. of California, Davis, CA (United States). Dept. of Biological and Agricultural Engineering
Joint BioEnergy Inst. (JBEI), Emeryville, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Science and Engineering Division
Joint BioEnergy Inst. (JBEI), Emeryville, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biology and Biotechnology Division
Univ. of California, Davis, CA (United States). Dept. of Biological and Agricultural Engineering; Joint BioEnergy Inst. (JBEI), Emeryville, CA (United States)

Chemical and physical pretreatment of biomass is a critical step in the conversion of lignocellulose to biofuels and bioproducts. Ionic liquid (IL) pretreatment has attracted significant attention due to the unique ability of certain ILs to solubilize some or all components of the plant cell wall. However, these ILs inhibit not only the enzyme activities but also the growth and productivity of microorganisms used in downstream hydrolysis and fermentation processes. While pretreated biomass can be washed to remove residual IL and reduce inhibition, extensive washing is costly and not feasible in large-scale processes. IL-tolerant microorganisms and microbial communities have been discovered from environmental samples and studies begun to elucidate mechanisms of IL tolerance. The discovery of IL tolerance in environmental microbial communities and individual microbes has lead to the proposal of molecular mechanisms of resistance. Here, we review recent progress on discovering IL-tolerant microorganisms, identifying metabolic pathways and mechanisms of tolerance, and engineering microorganisms for IL tolerance. Research in these areas will yield new approaches to overcome inhibition in lignocellulosic biomass bioconversion processes and increase opportunities for the use of ILs in biomass pretreatment.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); US Dept. of Agriculture (USDA) National Inst. of Food and Agriculture (NIFA)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1436606

Journal Information:: Applied Microbiology and Biotechnology, Vol. 100, Issue 24; ISSN 0175-7598

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 32 works

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