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Title: Brain-specific enhancers for cell-based therapy

Patent ·
OSTI ID:1436498
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Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
9,952,216
Application Number:
14/512,306
OSTI ID:
1436498
Resource Relation:
Patent File Date: 2014 Oct 10
Country of Publication:
United States
Language:
English

References (4)

Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal patent July 1995
The Human Synaptotagmin IV Gene Defines an Evolutionary Break Point between Syntenic Mouse and Human Chromosome Regions but Retains Ligand Inducibility and Tissue Specificity journal August 2000
Gene Expression Signatures of Seven Individual Human Embryonic Stem Cell Lines journal October 2005
Flow cytometric and cytogenetic analyses in human spontaneous abortions journal June 1993

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