Variants of cellobiohydrolases

Bott, Richard R.; Foukaraki, Maria; Hommes, Ronaldus Wilhelmus; Kaper, Thijs; Kelemen, Bradley R.; Kralj, Slavko; Nikolaev, Igor; Sandgren, Mats; Van Lieshout, Johannes Franciscus Thomas; Van Stigt Thans, Sander

Title: Variants of cellobiohydrolases

Patent · Tue Apr 10 00:00:00 EDT 2018

OSTI ID:1434527

Bott, Richard R.; Foukaraki, Maria; Hommes, Ronaldus Wilhelmus; Kaper, Thijs; Kelemen, Bradley R.; Kralj, Slavko; Nikolaev, Igor; Sandgren, Mats; Van Lieshout, Johannes Franciscus Thomas; Van Stigt Thans, Sander

Disclosed are a number of homologs and variants of Hypocrea jecorina Ce17A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.

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Research Organization:: DANISCO US INC, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FC36-08GO18078

Assignee:: DANISCO US INC (CA)

Patent Number(s):: 9,938,551

Application Number:: 14/650,285

OSTI ID:: 1434527

Resource Relation:: Patent File Date: 2013 Dec 10

Country of Publication:: United States

Language:: English

References (158)

Ion-exchange chromatographic purification and quantitative analysis of Trichoderma reesei cellulases cellobiohydrolase I, II and endoglucanase II by fast protein liquid chromatography Medve, József; Lee, Dora; Tjerneld, Folke Journal of Chromatography A, Vol. 808, Issue 1-2, p. 153-165 https://doi.org/10.1016/S0021-9673(98)00132-0	journal	May 1998
Identification of a fungal cutinase promoter that is inducible by a plant signal via a phosphorylated trans-acting factor. Bajar, A.; Podila, G. K.; Kolattukudy, P. E. Proceedings of the National Academy of Sciences, Vol. 88, Issue 18, p. 8208-8212 https://doi.org/10.1073/pnas.88.18.8208	journal	September 1991
The roles and function of cellulose-binding domains Linder, Markus; Teeri, Tuula T. Journal of Biotechnology, Vol. 57, Issue 1-3, p. 15-28 https://doi.org/10.1016/S0168-1656(97)00087-4	journal	September 1997
Reshaping human antibodies: grafting an antilysozyme activity Verhoeyen, M.; Milstein, C.; Winter, G. Science, Vol. 239, Issue 4847, p. 1534-1536 https://doi.org/10.1126/science.2451287	journal	March 1988
Detergent compositions containing cellulase compositions deficient in CBH I type components Clarkson, Kathleen A.; Larenas, Edward; Shoemaker, Sharon https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6162782 US Patent Document 6,162,782	patent	December 2000
Polypeptides having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same Harris, Paul; Maiyuran, Suchindra; Brown, Kimberly https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100306881 US Patent Application 12/745993; 20100306881	patent-application	December 2010
Genomic organization of a cellulase gene family in Phanerochaete chrysosporium Covert, Sarah F.; Bolduc, Jennifer; Cullen, Dan Current Genetics, Vol. 22, Issue 5, p. 407-413 https://doi.org/10.1007/BF00352442	journal	November 1992
High-resolution crystal structures reveal how a cellulose chain is bound in the 50 Å long tunnel of cellobiohydrolase I from Trichoderma reesei Divne, Christina; Ståhlberg, Jerry; Teeri, Tuula T. Journal of Molecular Biology, Vol. 275, Issue 2, p. 309-325 https://doi.org/10.1006/jmbi.1997.1437	journal	January 1998
Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding. Matthews, B. W.; Nicholson, H.; Becktel, W. J. Proceedings of the National Academy of Sciences, Vol. 84, Issue 19, p. 6663-6667 https://doi.org/10.1073/pnas.84.19.6663	journal	October 1987
CelS: a novel endoglucanase identified from Erwinia carotovora subsp. carotovora Saarilahti, Hannu T.; Henrissat, Bernard; Tapio Palva, E. Gene, Vol. 90, Issue 1, p. 9-14 https://doi.org/10.1016/0378-1119(90)90433-R	journal	May 1990
Cloning and sequencing of cellulase cDNA from Aspergillus kawachii and its expression in Saccharomyces cerevisiae Sakamoto, S.; Tamura, G.; Ito, K. Current Genetics, Vol. 27, Issue 5, p. 435-439 https://doi.org/10.1007/BF00311212	journal	April 1995
Complete nucleotide sequence of a gene coding for Aspergillus aculeatus cellulase (FI-CMCase) Ooi, Toshihiko; Shinmyo, Atsuhiko; Okada, Hirosuke Nucleic Acids Research, Vol. 18, Issue 19 https://doi.org/10.1093/nar/18.19.5884	journal	January 1990
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect Eriksson, A.; Baase, W.; Zhang, X. Science, Vol. 255, Issue 5041, p. 178-183 https://doi.org/10.1126/science.1553543	journal	January 1992
Secretion of Trichoderma reesei β-glucosidase by Saccharomyces cerevisiae Cummings, C.; Fowler, T. Current Genetics, Vol. 29, Issue 3, p. 227-233 https://doi.org/10.1007/BF02221552	journal	February 1996
Production and use of plant degrading materials Daniell, Henry https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090325240 US Patent Application 12/396382; 20090325240	patent-application	December 2009
Homologous domains in Trichoderma reesei cellulolytic enzymes: Gene sequence and expression of cellobiohydrolase II Teeri, Tuula T.; Lehtovaara, Päivi; Kauppinen, Sakari Gene, Vol. 51, Issue 1, p. 43-52 https://doi.org/10.1016/0378-1119(87)90472-0	journal	January 1987
Methods for Determining Cellulolytic Enhancing Activity of a Polypeptide Sweeney, Matthew David; Vlasenko, Elena https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100159494 US Patent Application 12/641075; 20100159494	patent-application	June 2010
ACEII, a Novel Transcriptional Activator Involved in Regulation of Cellulase and Xylanase Genes of Trichoderma reesei Aro, Nina; Saloheimo, Anu; Ilmén, Marja Journal of Biological Chemistry, Vol. 276, Issue 26, p. 24309-24314 https://doi.org/10.1074/jbc.M003624200	journal	April 2001
Codon optimization of xylanase gene xynB from the thermophilic bacterium Dictyoglomus thermophilum for expression in the filamentous fungus Trichoderma reesei Te'o, Valentino S.J.; Cziferszky, Angela E.; Bergquist, Peter L. FEMS Microbiology Letters, Vol. 190, Issue 1, p. 13-19 https://doi.org/10.1111/j.1574-6968.2000.tb09255.x	journal	September 2000
Structure, organization, and transcription of a cellobiohydrolase gene cluster from Phanerochaete chrysosporium. Covert, S. F.; Vanden Wymelenberg, A.; Cullen, D. Applied and Environmental Microbiology, Vol. 58, Issue 7 https://doi.org/10.1128/AEM.58.7.2168-2175.1992	journal	January 1992
Enzyme feed additive and animal feed including it Bedford, Michael; Morgan, Andrew; Fowler, Timothy https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6562340 US Patent Document 6,562,340	patent	May 2003
Fractionation of cellulase and β-glucosidase in a Trichoderma reesei culture liquid by use of two-phase partitioning Brumbauer, Anikó; Johansson, Göte; Réczey, Kati Bioseparation, Vol. 7, Issue 6, p. 287-295 https://doi.org/10.1023/A:1008153418019	journal	November 1999
The molecular biology of the yeast saccharomyces Gichner, T. Biologia Plantarum, Vol. 24, Issue 5, p. 340-340 https://doi.org/10.1007/BF02909099	journal	September 1982
Novel CBH1-EG1 Fusion Proteins and Use Thereof Blanquet, Senta; Brien, Gaelle; Lopez Ferreira, Nicolas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130177959 US Patent Application 13/634924; 20130177959	patent-application	July 2013
Crystalline cellulose degradation: new insight into the function of cellobiohydrolases Teeri, Tuula T. Trends in Biotechnology, Vol. 15, Issue 5, p. 160-167 https://doi.org/10.1016/S0167-7799(97)01032-9	journal	May 1997
Molecular Biology of Cellulolytic Fungi Nevalainen, H.; Penttilä, M.; Kück, Ulrich Genetics and Biotechnology, p. 303-319 https://doi.org/10.1007/978-3-662-10364-7_18	book	January 1995
Properties of cellulolytic enzyme systems Wood, Thomas M. Biochemical Society Transactions, Vol. 13, Issue 2, p. 407-410 https://doi.org/10.1042/bst0130407	journal	April 1985
Optimized Cellulase Enzymes Kettling, Ulrich; Reisinger, Christoph; Bruck, Thomas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130123115 US Patent Application 13/578291; 20130123115	patent-application	May 2013
Polypeptides having expansin Activity and Polynucleotides Encoding Same Lopez de Leon, Alfredo; Rey, Michael; Harris, Paul https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110296558 US Patent Application 13/144863; 20110296558	patent-application	December 2011
Recombinant immunoglobin preparations Cabilly, Shmuel; Heyneker, Herbert L.; Holmes, William E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4816567 US Patent Document 4,816,567	patent	March 1989
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same Lopez de Leon, Alfredo; Ding, Hanshu; Brown, Kimberly https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090019608 US Patent Application 12/130722; 20090019608	patent-application	January 2009
Specific quantification of trichoderma reesei cellulases in reconstituted mixtures and its application to cellulase-cellulose binding studies Nidetzky, Bernd; Claeyssens, Marc Biotechnology and Bioengineering, Vol. 44, Issue 8, p. 961-966 https://doi.org/10.1002/bit.260440812	journal	October 1994
Cloning and Sequencing of a Rhodothermus marinus Gene, bglA, Coding for a Thermostable beta-Glucanase and its Expression in Escherichia coli Spilliaert, Remi; Hreggvidsson, Gudmundur Oli; Kristjansson, Jakob Kristjan European Journal of Biochemistry, Vol. 224, Issue 3, p. 923-930 https://doi.org/10.1111/j.1432-1033.1994.00923.x	journal	September 1994
Family 7 cellobiohydrolases from Phanerochaete chrysosporium: crystal structure of the catalytic module of Cel7D (CBH58) at 1.32 Å resolution and homology models of the isozymes Muñoz, Inés G.; Ubhayasekera, Wimal; Henriksson, Hongbin Journal of Molecular Biology, Vol. 314, Issue 5, p. 1097-1111 https://doi.org/10.1006/jmbi.2000.5180	journal	December 2001
Cloning and sequencing of the cDNA encoding β-glucosidase 1 from Aspergillus aculeatus Kawaguchi, Takashi; Enoki, Tatsuji; Tsurumaki, Shinji Gene, Vol. 173, Issue 2, p. 287-288 https://doi.org/10.1016/0378-1119(96)00179-5	journal	September 1996
Reshaping human antibodies for therapy Riechmann, Lutz; Clark, Michael; Waldmann, Herman Nature, Vol. 332, Issue 6162, p. 323-327 https://doi.org/10.1038/332323a0	journal	March 1988
Molecular Cloning of Exo–Cellobiohydrolase I Derived from Trichoderma Reesei Strain L27 Shoemaker, S.; Schweickart, V.; Ladner, M. Nature Biotechnology, Vol. 1, Issue 8, p. 691-696 https://doi.org/10.1038/nbt1083-691	journal	October 1983
Transformation of Aspergillus nidulans by using a trpC plasmid. Yelton, M. M.; Hamer, J. E.; Timberlake, W. E. Proceedings of the National Academy of Sciences, Vol. 81, Issue 5, p. 1470-1474 https://doi.org/10.1073/pnas.81.5.1470	journal	March 1984
Method for producing ascorbic acid intermediates Boston, Matthew G.; Swanson, Barbara A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6599722 US Patent Document 6,599,722	patent	July 2003
Improved transformation efficiency of Aspergillus niger using the homologous niaD gene for nitrate reductase Campbell, Edward I.; Unkles, Shiela E.; Macro, Janet A. Current Genetics, Vol. 16, Issue 1, p. 53-56 https://doi.org/10.1007/BF00411084	journal	July 1989
Methods for transforming and expression screening of filamentous fungal cells with a DNA library Teter, Sarah; Lamsa, Michael; Cherry, Joel https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060172379 US Patent Application 11/140150; 20060172379	patent-application	August 2006
Penicillopepsin-JT2, a recombinant enzyme from Penicillium janthinellum and the contribution of a hydrogen bond in subsite S ₃ to k _cat Stubbs, Marlene; Ngo, Kenny Q.P.; Cunningham, Annie Protein Science, Vol. 9, Issue 5, p. 991-1001 https://doi.org/10.1110/ps.9.5.991	journal	January 2000
Improved oligonudeotide site-directed rautagenesis using M13 vectors Carter, Paul; Bedouelle, Hugues; Winter, Greg Nucleic Acids Research, Vol. 13, Issue 12, p. 4431-4443 https://doi.org/10.1093/nar/13.12.4431	journal	January 1985
Novel cellulases and their uses Vehmaanpera, Jari; Puranen, Terhi; Valtakari, Leena https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060246566 US Patent Application 11/119526; 20060246566	patent-application	November 2006
Novel variant hypocrea jercorina CBH1 cellulases Day, Anthony; Goedegebuur, Frits; Gualfetti, Peter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070173431 US Patent Application 11/728219; 20070173431	patent-application	July 2007
[57] Rethinking your purification procedure Deutscher, Murray P. Guide to Protein Purification https://doi.org/10.1016/0076-6879(90)82059-B	book	January 1990
Continuous cultures of fused cells secreting antibody of predefined specificity Köhler, G.; Milstein, C. Nature, Vol. 256, Issue 5517, p. 495-497 https://doi.org/10.1038/256495a0	journal	August 1975
Simultaneous saccharification and fermentation of lignocellulosic wastes to ethanol using a thermotolerant yeast Hari Krishna, S.; Janardhan Reddy, T.; Chowdary, G. V. Bioresource Technology, Vol. 77, Issue 2, p. 193-196 https://doi.org/10.1016/S0960-8524(00)00151-6	journal	April 2001
Basic local alignment search tool Altschul, Stephen F.; Gish, Warren; Miller, Webb Journal of Molecular Biology, Vol. 215, Issue 3, p. 403-410 https://doi.org/10.1016/S0022-2836(05)80360-2	journal	October 1990
Variant Hypocrea jecorina CBH1 cellulases Day, Anthony G.; Goedegebuur, Frits; Gualfetti, Peter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7972832 US Patent Document 7,972,832	patent	July 2011
Cloning, sequencing and overexpression of a Rhodothermus marinus gene encoding a thermostable cellulase of glycosyl hydrolase family 12 Halldórsdóttir, S.; Thórólfsdót, E. T.; Spilliaert, R. Applied Microbiology and Biotechnology, Vol. 49, Issue 3, p. 277-284 https://doi.org/10.1007/s002530051169	journal	March 1998
Cellobiohydrolase I Enzymes Adney, William S.; Himmel, Michael E.; Decker, Stephen R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090162916 US Patent Application 12/123352; 20090162916	patent-application	June 2009
Comparison of biosequences Smith, Temple F.; Waterman, Michael S. Advances in Applied Mathematics, Vol. 2, Issue 4, p. 482-489 https://doi.org/10.1016/0196-8858(81)90046-4	journal	December 1981
Cellulase enzymes and systems for their expressions Fowler, Timothy; Clarkson, Kathleen A.; Ward, Michael https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5861271 US Patent Document 5,861,271	patent	January 1999
Trichoderma reesei cellobiohydrolase I with an endoglucanase cellulose-binding domain: action on bacterial microcrystalline cellulose Srisodsuk, Malee; Lehtiö, Janne; Linder, Markus Journal of Biotechnology, Vol. 57, Issue 1-3, p. 49-57 https://doi.org/10.1016/S0168-1656(97)00088-6	journal	September 1997
Methods for stonewashing fabrics using endoglucanases Clarkson, Kathleen A.; Larenas, Edmund; Weiss, Geoffrey L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5650322 US Patent Document 5,650,322	patent	July 1997
Variants of glycoside hydrolases Teter, Sarah; Cherry, Joel; Ward, Connie https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050048619 US Patent Application 10/926223; 20050048619	patent-application	March 2005
Synthesis and secretion of wheat α-amylase in Saccharomyces cerevisiae Rothstein, Steven J.; Lahners, Kristine N.; Lazarus, Colin M. Gene, Vol. 55, Issue 2-3, p. 353-356 https://doi.org/10.1016/0378-1119(87)90296-4	journal	January 1987
Agrobacterium mediated transformation of moulds, in particular those belonging to the genus Aspergillus Beijersbergen, Alida Godelieve Maria; Bundock, Paul; Gouka, Robertus Johannes https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6255115 US Patent Document 6,255,115	patent	July 2001
Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof Schulein, Martin; Levring, Kirsten B. o. slashed. egh https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5776757 US Patent Document 5,776,757	patent	July 1998
Detection of a Stable Intermediate in the Thermal Unfolding of a Cysteine-Free Form of Dihydrofolate Reductase from Escherichia Coli Luo, J.; Iwakura, M.; Matthews, C. R. Biochemistry, Vol. 34, Issue 33, p. 10669-10675 https://doi.org/10.1021/bi00033a043	journal	August 1995
Cellobiohydrolase I gene and improved variants Adney, William S.; Decker, Stephen R.; McCarter, Suzanne https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030170861 US Patent Document 10/031496; 20030170861	patent-application	September 2003
Crystal structure of a bacterial family-III cellulose-binding domain: a general mechanism for attachment to cellulose. Tormo, J.; Lamed, R.; Chirino, A. J. The EMBO Journal, Vol. 15, Issue 21, p. 5739-5751 https://doi.org/10.1002/j.1460-2075.1996.tb00960.x	journal	November 1996
Trichoderma reesei cellulases and their core domains in the hydrolysis and modification of chemical pulp Suurnäkki, A.; Tenkanen, M.; Siika-aho, M. Cellulose, Vol. 7, Issue 2, p. 189-209 https://doi.org/10.1023/A:1009280109519	journal	June 2000
Structural and Genetic Analysis of Protein Stability Matthews, Brian W. Annual Review of Biochemistry, Vol. 62, Issue 1, p. 139-160 https://doi.org/10.1146/annurev.bi.62.070193.001035	journal	June 1993
Construction of mutant and chimeric genes using the polymerase chain reaction Vallette, Francois; Mege, Emmanuelle; Reiss, Allison Nucleic Acids Research, Vol. 17, Issue 2, p. 723-733 https://doi.org/10.1093/nar/17.2.723	journal	January 1989
Methods of reducing the inhibitory effect of a redox active metal ion on the enzymatic hydrolysis of cellulosic material Xu, Feng https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090130707 US Patent Application 12/263268; 20090130707	patent-application	May 2009
Multiple Proline Substitutions Cumulatively Thermostabilize Bacillus Cereus ATCC7064 Oligo-1,6-Glucosidase. Irrefragable Proof Supporting the Proline Rule Watanabe, Kunihiko; Masuda, Tomoko; Ohashi, Hiroyuki European Journal of Biochemistry, Vol. 226, Issue 2, p. 277-283 https://doi.org/10.1111/j.1432-1033.1994.tb20051.x	journal	December 1994
A New Model For Enzymatic Hydrolysis of Cellulose Based on the Two-Domain Structure of Cellobiohydrolase I Ståhlberg, Jerry; Johansson, Gunnar; Pettersson, Göran Nature Biotechnology, Vol. 9, Issue 3, p. 286-290 https://doi.org/10.1038/nbt0391-286	journal	March 1991
Polypeptides having Beta-glucosidase Activity and Polynucleotides Encoding Same Schnorr, Kirk; Rey, Michael https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120096597 US Patent Application 13/144810; 20120096597	patent-application	April 2012
Advanced Bioethanol Production Technologies: A Perspective Himmel, Michael E.; Adney, William S.; Baker, John O. ACS Symposium Series https://doi.org/10.1021/bk-1997-0666.ch001	book	May 1997
Cellobiohydrolase Variants Mitchell, Vesna; Wojciechowski, Grzegort; Alvizo, Oscar https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120003703 US Patent Application 13/107849; 20120003703	patent-application	January 2012
Structure of Cellulases and Their Applications Ohmiya, Kunio; Sakka, Kazuo; Karita, Shuichi Biotechnology and Genetic Engineering Reviews, Vol. 14, Issue 1, p. 365-414 https://doi.org/10.1080/02648725.1997.10647949	journal	April 1997
Expression of Aureobasidium pullulans xynA in, and secretion of the xylanase from, Saccharomyces cerevisiae. Li, X. L.; Ljungdahl, L. G. Applied and environmental microbiology, Vol. 62, Issue 1 https://doi.org/10.1128/AEM.62.1.209-213.1996	journal	January 1996
Amino acid substitution matrices from protein blocks. Henikoff, S.; Henikoff, J. G. Proceedings of the National Academy of Sciences, Vol. 89, Issue 22, p. 10915-10919 https://doi.org/10.1073/pnas.89.22.10915	journal	November 1992
Methods for increasing enzymatic hydrolysis of cellulosic material in the presence of a peroxidase Xu, Feng; Quinlan, Jason https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100159509 US Patent Application 12/638920; 20100159509	patent-application	June 2010
CBH1 homologs and variant CBH1 cellulases Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7452707 US Patent Document 7,452,707	patent	November 2008
Regulation of cellulase gene expression in the filamentous fungus Trichoderma reesei. Ilmén, M.; Saloheimo, A.; Onnela, M. L. Applied and environmental microbiology, Vol. 63, Issue 4 https://doi.org/10.1128/AEM.63.4.1298-1306.1997	journal	January 1997
Molecular evidence that the asexual industrial fungus Trichoderma reesei is a clonal derivative of the ascomycete Hypocrea jecorina. Kuhls, K.; Lieckfeldt, E.; Samuels, G. J. Proceedings of the National Academy of Sciences, Vol. 93, Issue 15, p. 7755-7760 https://doi.org/10.1073/pnas.93.15.7755	journal	July 1996
Nucleotide sequence of the cellobiohydrolase gene from Trichoderma viride Cheng, Cheng; Tsukagoshi, Norihiro; Udaka, Shigezo Nucleic Acids Research, Vol. 18, Issue 18, p. 5559-5559 https://doi.org/10.1093/nar/18.18.5559	journal	January 1990
A versatile transformation system for the cellulolytic filamentous fungus Trichoderma reesei Penttilä, Merja; Nevalainen, Helena; Rättö, Marjaana Gene, Vol. 61, Issue 2, p. 155-164 https://doi.org/10.1016/0378-1119(87)90110-7	journal	January 1987
Isolation and Characterization of Schizochytrium Aggregatum Cellobiohydrolase I (CBH I) Brevnova, Elena E.; Flatt, Jim; Gandhi, Chhayal https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110312054 US Patent Application 13/003199; 20110312054	patent-application	December 2011
Methods for increasing hydrolysis of cellulosic material in the presence of cellobiose dehydrogenase Sweeney, Matthew D.; Vlasenko, Elena; Abbate, Eric https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100159536 US Patent Application 12/641110; 20100159536	patent-application	June 2010
Polypeptides having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same Harris, Paul; Maiyuran, Suchindra; Brown, Kimberly https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100299788 US Patent Application 12/746022; 20100299788	patent-application	November 2010
Studies of the cellulolytic system of Trichoderma reesei QM 9414. Analysis of domain function in two cellobiohydrolases by limited proteolysis TOMME, Peter; TILBEURGH, Herman; PETTERSSON, Goran European Journal of Biochemistry, Vol. 170, Issue 3, p. 575-581 https://doi.org/10.1111/j.1432-1033.1988.tb13736.x	journal	January 1988
Characteristics of fungal cellulases Goyal, Anil; Ghosh, Bijan; Eveleigh, Douglas Bioresource Technology, Vol. 36, Issue 1, p. 37-50 https://doi.org/10.1016/0960-8524(91)90098-5	journal	January 1991
Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites Wells, James A.; Vasser, Mark; Powers, David B. Gene, Vol. 34, Issue 2-3, p. 315-323 https://doi.org/10.1016/0378-1119(85)90140-4	journal	January 1985
Method for treating cotton-containing fabric with a cellulase composition containing endoglucanase components and which composition is free of exo-cellobiohydrolase I Clarkson, Kathleen A.; Larenas, Edward; Weiss, Geoffrey L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5246853 US Patent Document 5,246,853	patent	September 1993
Engineering thermostability: lessons from thermophilic proteins Russell, Rupert J. M.; Taylor, Garry L. Current Opinion in Biotechnology, Vol. 6, Issue 4, p. 370-374 https://doi.org/10.1016/0958-1669(95)80064-6	journal	January 1995
Separation of endo- and exo-type cellulases using a new affinity chromatography method van Tilbeurgh, Herman; Bhikhabhai, Ramagauri; Göran Pettersson, L. FEBS Letters, Vol. 169, Issue 2, p. 215-218 https://doi.org/10.1016/0014-5793(84)80321-X	journal	April 1984
Yeast Expressing Cellulases for Simultaneous Saccharification and Fermentation Using Cellulose McBride, John; Brevnova, Elena; Mellon, Mark https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120129229 US Patent Application 13/130549; 20120129229	patent-application	May 2012
Characterization of cellulases by HPLC separation Fliess, A.; Schügerl, K. European Journal of Applied Microbiology and Biotechnology, Vol. 17, Issue 5, p. 314-318 https://doi.org/10.1007/BF00508028	journal	January 1983
Construction of Protrophic/Celluloytic Yeast Strains Expressing Tethered and Secreted Cellulases Mcbride, John; Lynd, Lee; Deleault, Kristen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110189744 US Patent Document 12/992001; 20110189744	patent-application	August 2011
Conjugative transfer of a shuttle plasmid for Escherichia coli to Mycobacterium smegmatis Lazraq, R.; Clavel-Sérès, S.; David, H. L. FEMS Microbiology Letters, Vol. 69, Issue 1-2, p. 135-138 https://doi.org/10.1111/j.1574-6968.1990.tb04189.x	journal	May 1990
Methods for reducing the harshness of a cotton-containing fabric Schulein, Martin; Levring, Kirsten B. o. slashed. egh https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5648263 US Patent Document 5,648,263	patent	July 1997
Engineering of a glycosidase Family 7 cellobiohydrolase to more alkaline pH optimum: the pH behaviour of Trichoderma reesei Cel7A and its E223S/ A224H/L225V/T226A/D262G mutant Becker, Dieter; Braet, Christophe; Brumer, Harry Biochemical Journal, Vol. 356, Issue 1, p. 19-30 https://doi.org/10.1042/bj3560019	journal	May 2001
Purification and characterization of a β-glucosidase from solid-state cultures of Humicola grisea var. thermoidea Filho, Edivaldo Ximenes Ferreira Canadian Journal of Microbiology, Vol. 42, Issue 1, p. 1-5 https://doi.org/10.1139/m96-001	journal	January 1996
Transformation of Trichoderma harzianum by high-voltage electric pulse Goldman, G. H.; Van Montagu, M.; Herrera-Estrella, A. Current Genetics, Vol. 17, Issue 2, p. 169-174 https://doi.org/10.1007/BF00312863	journal	February 1990
Enzymes, Energy, and the Environment: A Strategic Perspective on the U.S. Department of Energy's Research and Development Activities for Bioethanol Sheehan, J.; Himmel, M. Biotechnology Progress, Vol. 15, Issue 5, p. 817-827 https://doi.org/10.1021/bp990110d	journal	October 1999
DNA sequence encoding endoglucanase III cellulase Ward, Michael; Clarkson, Kathleen A.; Larenas, Edmund https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5475101 US Patent Document 5,475,101	patent	December 1995
Randomization of genes by PCR mutagenesis. Cadwell, R. C.; Joyce, G. F. Genome Research, Vol. 2, Issue 1, p. 28-33 https://doi.org/10.1101/gr.2.1.28	journal	August 1992
Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Hu, Q. J.; Bautista, C.; Edwards, G. M. Molecular and Cellular Biology, Vol. 11, Issue 11, p. 5792-5799 https://doi.org/10.1128/MCB.11.11.5792	journal	November 1991
Oligosaccharide specificity of a family 7 endoglucanase: insertion of potential sugar-binding subsites Davies, Gideon J.; Ducros, Valérie; Lewis, Richard J. Journal of Biotechnology, Vol. 57, Issue 1-3, p. 91-100 https://doi.org/10.1016/S0168-1656(97)00092-8	journal	September 1997
Use of Aspergillus overproducing mutants, cured for intergrated plasmid, to overproduce heterologous proteins Ward, Michael; Wilson, Lori J.; Kodama, Katherine H. Applied Microbiology and Biotechnology, Vol. 39, Issue 6, p. 738-743 https://doi.org/10.1007/BF00164459	journal	August 1993
Expression of two Trichoderma reesei endoglucanases in the yeast Saccharomyces cerevisiae Panttilä, Merja E.; André, Lars; Saloheimo, Markku Yeast, Vol. 3, Issue 3, p. 175-185 https://doi.org/10.1002/yea.320030305	journal	September 1987
Recombinant Yeast Strains Expressing Tethered Cellulase Enzymes McBride, John E. E.; Delault, Kristen M.; Lynd, Lee R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100075363 US Patent Application 12/516175; 20100075363	patent-application	March 2010
The crystal structure of the catalytic core domain of endoglucanase I from Trichoderma reesei at 3.6 Å resolution, and a comparison with related enzymes Kleywegt, Gerard J.; Zou, Jin-Yu; Divne, Christina Journal of Molecular Biology, Vol. 272, Issue 3, p. 383-397 https://doi.org/10.1006/jmbi.1997.1243	journal	September 1997
Contribution of hydrophobic interactions to protein stability Kellis, James T.; Nyberg, Kerstin; S˘ail, Das̆a Nature, Vol. 333, Issue 6175, p. 784-786 https://doi.org/10.1038/333784a0	journal	June 1988
Methods of reducing the inhibitory effect of a tannin on the enzymatic hydrolysis of cellulosic material Xu, Feng https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090123979 US Patent Application 12/262738; 20090123979	patent-application	May 2009
Novel Lignin-Resistant Cellulase Enzymes Scott, Brian R.; St-Pierre, Patrick; Lavigne, James https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100221778 US Patent Application 12/713516; 20100221778	patent-application	September 2010
Rapid and efficient site-specific mutagenesis without phenotypic selection. Kunkel, T. A. Proceedings of the National Academy of Sciences, Vol. 82, Issue 2, p. 488-492 https://doi.org/10.1073/pnas.82.2.488	journal	January 1985
Improved tools for biological sequence comparison. Pearson, W. R.; Lipman, D. J. Proceedings of the National Academy of Sciences, Vol. 85, Issue 8, p. 2444-2448 https://doi.org/10.1073/pnas.85.8.2444	journal	April 1988
Production of Antigen-Specific Human Antibodies from Mice Engineered with Human Heavy and Light Chain YACs Jakobovits, Aya; Green, Larry L.; Hardy, Margaret C. Annals of the New York Academy of Sciences, Vol. 764, Issue 1, p. 525-535 https://doi.org/10.1111/j.1749-6632.1995.tb55878.x	journal	September 1995
Comparison of family 12 glycoside hydrolases and recruited substitutions important for thermal stability Sandgren, Mats; Gualfetti, Peter J.; Shaw, Andrew Protein Science, Vol. 12, Issue 4, p. 848-860 https://doi.org/10.1110/ps.0237703	journal	April 2003
Site-directed mutagenesis of the putative catalytic residues of Trichoderma reesci cellobiohydrolase I and endoglucanase I Mitsuishi, Yasushi; Nitisinprasert, Sunee; Saloheimo, Markku FEBS Letters, Vol. 275, Issue 1-2, p. 135-138 https://doi.org/10.1016/0014-5793(90)81457-Y	journal	November 1990
Determinants of Enzyme Thermostability Observed in the Molecular Structure of Thermus aquaticus d -Glyceraldehyde-3-phosphate Dehydrogenase at 2.5 Å Resolution Tanner, John J.; Hecht, Ralph M.; Krause, Kurt L. Biochemistry, Vol. 35, Issue 8, p. 2597-2609 https://doi.org/10.1021/bi951988q	journal	January 1996
Isolation of uridine auxotrophs from Trichoderma reesei and efficient transformation with the cloned ura3 and ura5 genes Bergès, Thierry; Barreau, Christian Current Genetics, Vol. 19, Issue 5, p. 359-365 https://doi.org/10.1007/BF00309596	journal	May 1991
Biolistic transformation of Trichoderma harzianum and Gliocladium virens using plasmid and genomic DNA Lorito, M.; Hayes, C. K.; Di Pietro, A. Current Genetics, Vol. 24, Issue 4, p. 349-356 https://doi.org/10.1007/BF00336788	journal	October 1993
Detergent composition for clothing incorporating a cellulase Suzuki, Akira; Ito, Susumu; Okamoto, Kikuhiko https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4822516 US Patent Document 4,822,516	patent	April 1989
Polypeptides having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same Harris, Paul; Maiyuran, Suchindra; Brown, Kimberly https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100304434 US Patent Application 12/745985; 20100304434	patent-application	December 2010
[79] Purification of all glycolytic enzymes from one muscle extract Scopes, Robert K.; Stoter, Ann Methods in Enzymology, Vol. 90, p. 479-490 https://doi.org/10.1016/S0076-6879(82)90175-6	journal	January 1982
EGIII, a new endoglucanase from Trichoderma reesei: the characterization of both gene and enzyme Saloheimo, M.; Lehtovaara, P.; Penttilä, M. Gene, Vol. 63, Issue 1, p. 11-21 https://doi.org/10.1016/0378-1119(88)90541-0	journal	March 1988
A general method applicable to the search for similarities in the amino acid sequence of two proteins Needleman, Saul B.; Wunsch, Christian D. Journal of Molecular Biology, Vol. 48, Issue 3, p. 443-453 https://doi.org/10.1016/0022-2836(70)90057-4	journal	March 1970
Polypeptides having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same Harris, Paul; Maiyuran, Suchindra; Brown, Kimberly https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100299789 US Patent Application 12/746003; 20100299789	patent-application	November 2010
Isolation and partial characterization of cellulose-degrading strain of Streptomyces sp. LX from soil Li, X.; Gao, P. Letters in Applied Microbiology, Vol. 22, Issue 3, p. 209-213 https://doi.org/10.1111/j.1472-765X.1996.tb01145.x	journal	March 1996
Temperature adaptation of lactate dehydrogenase Structural, functional and genetic aspects Zuber, H. Biophysical Chemistry, Vol. 29, Issue 1-2, p. 171-179 https://doi.org/10.1016/0301-4622(88)87037-6	journal	February 1988
Heterologous Biomass Degrading Enzyme Expression in Thermoanaerobacterium Saccharolyticum Hau, Heidi; Rice, Chales; Herring, Chris https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120040409 US Patent Application 13/141952; 20120040409	patent-application	February 2012
Methods for measuring cellulase activities Wood, Thomas M.; Bhat, K. Mahalingeshwara Methods in Enzymology, Vol. 160, p. 87-112 https://doi.org/10.1016/0076-6879(88)60109-1	journal	January 1988
Methods of producing the cellulolytic enhancing activity of a polypeptide McFarland, Keith; Harris, Paul https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100129860 US Patent Application 12/598723; 20100129860	patent-application	May 2010
Cloning and relational analysis of 15 novel fungal endoglucanases from family 12 glycosyl hydrolase Goedegebuur, Frits; Fowler, Timothy; Phillips, Jay Current Genetics, Vol. 41, Issue 2, p. 89-98 https://doi.org/10.1007/s00294-002-0290-2	journal	May 2002
Efficient secretion of two fungal cellobiohydrolases by Saccharomyces cerevisiae Penttilä, Merja E.; André, Lars; Lehtovaara, Päivi Gene, Vol. 63, Issue 1, p. 103-112 https://doi.org/10.1016/0378-1119(88)90549-5	journal	March 1988
Cellulase families and their genes Knowles, Jonathan; Lehtovaara, Päivi; Teeri, Tuula Trends in Biotechnology, Vol. 5, Issue 9, p. 255-261 https://doi.org/10.1016/0167-7799(87)90102-8	journal	September 1987
Heterologous Expression of Fungal Cellobiohydrolases in Yeast Den Haan, Riaan; Van Zyl, Emile; Lagrange, Danie https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110124074 US Patent Application 12/992003; 20110124074	patent-application	May 2011
Self-Processing Plants and Plant Parts Lanahan, Michael B.; Basu, Shib S.; Batie, Christopher J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080289066 US Patent Application 10/591870; 20080289066	patent-application	November 2008
Replacing the complementarity-determining regions in a human antibody with those from a mouse Jones, Peter T.; Dear, Paul H.; Foote, Jefferson Nature, Vol. 321, Issue 6069, p. 522-525 https://doi.org/10.1038/321522a0	journal	May 1986
Urea and Thermal Equilibrium Denaturation Studies on the Dimerization Domain of Escherichia coli Trp Repressor Gloss, Lisa M.; Matthews, C. Robert Biochemistry, Vol. 36, Issue 19, p. 5612-5623 https://doi.org/10.1021/bi970056e	journal	May 1997
Fusion Proteins Between Plant Cell-Wall Degrading Enzymes and a Swollenin, and Their Uses Record, Eric; Levasseur, ANthony; Soloheimo, Markku https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090221039 US Patent Application 12/295870; 20090221039	patent-application	September 2009
Viruses and gene silencing in plants Baulcombe, D.; Calisher, Charles H.; Horzinek, M. C. 100 Years of Virology, p. 189-201 https://doi.org/10.1007/978-3-7091-6425-9_14	book	January 1999
Analytical separation of Trichoderma reesei cellulases by ion-exchange fast protein liquid chromatography Ellouz, S.; Durand, H.; Tiraby, G. Journal of Chromatography A, Vol. 396, p. 307-317 https://doi.org/10.1016/S0021-9673(01)94068-3	journal	January 1987
Cellobiohydrolase I gene and improved variants Adney, William S.; Decker, Stephen R.; Mc Carter, Suzanne https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7375197 US Patent Document 7,375,197	patent	May 2008
Molecular Cloning and Characterization of cel2 from the Fungus Cochlibolus carbonum Ahn, Joong-Hoon; Sposato, Paola; Kim, Su-Il Bioscience, Biotechnology, and Biochemistry, Vol. 65, Issue 6, p. 1406-1411 https://doi.org/10.1271/bbb.65.1406	journal	January 2001
Cellulases of Trichoderma reesei Schülein, Martin Methods in Enzymology, Vol. 160, p. 234-242 https://doi.org/10.1016/0076-6879(88)60125-X	journal	January 1988
Characterization of the secreted cellulases of Trichoderma reesei wild type and mutants during controlled fermentations Sheir-Neiss, G.; Montenecourt, B. S. Applied Microbiology and Biotechnology, Vol. 20, Issue 1, p. 46-53 https://doi.org/10.1007/BF00254645	journal	July 1984
Variant Humicola grisea CBH1.1 Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7951571 US Patent Document 7,951,571	patent	May 2011
Aromatic-aromatic interaction: a mechanism of protein structure stabilization Burley, S.; Petsko, G. Science, Vol. 229, Issue 4708, p. 23-28 https://doi.org/10.1126/science.3892686	journal	July 1985
CBH1 homologs and variant CBH1 cellulases Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7951570 US Patent Document 7,951,570	patent	May 2011
Applications and statistics for multiple high-scoring segments in molecular sequences. Karlin, S.; Altschul, S. F. Proceedings of the National Academy of Sciences, Vol. 90, Issue 12, p. 5873-5877 https://doi.org/10.1073/pnas.90.12.5873	journal	June 1993
Exploitation of the cellulase enzyme complex of neurospora Radford, Alan; Parish, John Howard https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5955270 US Patent Document 5,955,270	patent	September 1999
Methods and compositions for degrading cellulosic material Brown, Kimberly; Abbate, Eric https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100124769 US Patent Application 12/612401; 20100124769	patent-application	May 2010
Secretion of Trichoderma reesei β-glucosidase by Saccharomyces cerevisiae Cummings, C.; Fowler, T. Current Genetics, Vol. 29, Issue 3 https://doi.org/10.1007/s002940050040	journal	February 1996
Compositions for saccharification of cellulosic material McBrayer, Brett; Shaghasi, Tarana; Vlasenko, Elena https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110111453 US Patent Application 12/940952; 20110111453	patent-application	May 2011
Enzymic activities of endo-1,4-β-d-glucanases purified from Trichoderma viride Shoemaker, S. P.; Brown, R. D. Biochimica et Biophysica Acta (BBA) - Enzymology, Vol. 523, Issue 1, p. 133-146 https://doi.org/10.1016/0005-2744(78)90016-5	journal	March 1978
Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase Schulein, Martin; Levring, Kirsten B. o. slashed. egh https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5691178 US Patent Document 5,691,178	patent	November 1997
Methods for Increasing Hydrolysis of Cellulosic Material Xu, Feng; Quinlan, Jason; Tejirian, Ani https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100159535 US Patent Application 12/638881; 20100159535	patent-application	June 2010
Studies on the chromatographic fractionation of Trichoderma reesei cellulases by hydrophobic interaction Tomaz, Cândida T.; Queiroz, João A. Journal of Chromatography A, Vol. 865, Issue 1-2, p. 123-128 https://doi.org/10.1016/S0021-9673(99)00851-1	journal	December 1999
Detergent cellulase Barbesgaard, Peder O.; Jensen, Georg W.; Holm, Poul Jørgen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4435307 US Patent Document 4,435,307	patent	March 1984
Compositions for degrading cellulosic material Merino, Sandra; McFarland, Keith; Cherry, Joel https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080299613 US Patent Application 12/130838; 20080299613	patent-application	December 2008
Cellobiohydrolase variants and polynucleotides encoding same Wogulis, Mark https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110099671 US Patent Application 12/908339; 20110099671	patent-application	April 2011

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