The Bcl-2 apoptotic switch in cancer development and therapy
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journal
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February 2007 |
Cell Death
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journal
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January 2004 |
Targeting Apoptosis Pathways in Cancer Therapy
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journal
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May 2005 |
Bcl-2 and the regulation of programmed cell death
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journal
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January 1994 |
Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression: differential effects of Bcl-2 and Bcl-xL on Bax-induced caspase activation and apoptosis
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journal
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October 1997 |
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy
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journal
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September 2008 |
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
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journal
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December 2013 |
The Hallmarks of Cancer
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journal
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January 2000 |
A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
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journal
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May 2010 |
The landscape of somatic copy-number alteration across human cancers
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journal
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February 2010 |
Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency
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journal
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April 2012 |
Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells
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journal
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March 2005 |
Myeloid Cell Leukemia-1 Inversely Correlates with Glycogen Synthase Kinase-3β Activity and Associates with Poor Prognosis in Human Breast Cancer
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journal
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May 2007 |
Immunohistochemical Analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 Expression in Pancreatic Cancers
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journal
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January 1999 |
Bcl-x L and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis
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journal
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January 2009 |
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-xL is an essential survival protein of human myeloma cells
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journal
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July 2002 |
The antiapoptotic member of the Bcl-2 family Mcl-1 is a CTL target in cancer patients
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journal
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December 2004 |
Mechanism of Synergy of N-(4-Hydroxyphenyl)Retinamide and ABT-737 in Acute Lymphoblastic Leukemia Cell Lines: Mcl-1 Inactivation
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journal
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April 2008 |
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
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journal
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March 2011 |
Inducing apoptosis and enhancing chemosensitivity to Gemcitabine via RNA interference targeting Mcl-1 gene in pancreatic carcinoma cell
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journal
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February 2008 |
The BCL-2 protein family, BH3-mimetics and cancer therapy
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journal
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May 2015 |
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
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journal
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April 2004 |
Structural biology of the Bcl-2 family of proteins
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journal
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March 2004 |
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
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journal
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June 2010 |
Structural insights into the degradation of Mcl-1 induced by BH3 domains
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journal
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March 2007 |
Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia
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journal
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July 2014 |
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
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journal
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January 2013 |
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
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journal
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May 2008 |
Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors
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journal
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March 2011 |
Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer
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journal
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April 2012 |
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
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journal
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October 2016 |
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
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journal
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January 2017 |
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
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journal
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December 2012 |
Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design
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journal
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April 2015 |
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
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journal
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February 2016 |
Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors
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journal
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December 2016 |
Biologic and genetic characterization of the novel amyloidogenic lambda light chain–secreting human cell lines, ALMC-1 and ALMC-2
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journal
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September 2008 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
Phaser crystallographic software
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journal
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July 2007 |
The CCP4 suite programs for protein crystallography
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journal
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September 1994 |
Coot model-building tools for molecular graphics
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journal
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November 2004 |
Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization
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journal
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September 2004 |
SHELXT – Integrated space-group and crystal-structure determination
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journal
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January 2015 |
Crystal structure determination and refinement via SIR2014
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journal
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January 2015 |
Structure validation in chemical crystallography
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journal
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January 2009 |