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Title: Clinical Features of and Risk Factors for Fatal Ebola Virus Disease, Moyamba District, Sierra Leone, December 2014–February 2015

Journal Article · · Emerging Infectious Diseases
 [1];  [2];  [2];  [3];  [4];  [2];  [5];  [1];  [6];  [7];  [5];  [3];  [8];  [9];  [10];  [10];  [11];  [3];  [3];  [12] more »;  [13];  [7] « less
  1. Haukeland Univ. Hospital, Bergen (Norway)
  2. St. Olav Hospital, Trondheim (Norway)
  3. Moyamba District Hospital (Sierra Leone)
  4. Oslo Univ. Hospital (Norway)
  5. Medicos del Mundo, Madrid (Spain)
  6. Haraldsplass Diaconal Hospital, Bergen (Norway)
  7. Haukeland Univ. Hospital, Bergen (Norway); Univ. of Bergen (Norway)
  8. Hospital Son Espases, Palma de Mallorca (Spain)
  9. Medicos del Mundo, Madrid (Spain); Inst. de Investigacion de Palma (Spain)
  10. MRIGlobal, Rockville, MD (United States)
  11. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
  12. Public Health (Pakistan)
  13. Stavanger Univ. Hospital (Norway)
+ Show Author Affiliations

The current outbreak of Ebola virus disease (EVD) in West Africa has infected more than 28,000 people, killed more than 11,000 and disrupted social life. We studied retrospectively the clinical presentation and risk factors for fatal outcome among the 31 Ebola virus (EBV) positive patients admitted to the Ebola Treatment Center (ETC) in Moyamba District, Sierra Leone. We found a higher rate of bleeding manifestations than reported elsewhere during the current outbreak. Significant predictors for fatal outcome were shorter time from onset to admission, male sex, high viral load on initial lab test, severe pain, diarrhea, bloody stools, and development of other bleeding manifestations during hospital admission. Awareness of risk factors for fatal outcome could be used to identify patients in need of more intensive medical support. The lack of fever in as much as a third of EVD cases may have implications for temperature screening practices and case definitions.

Research Organization:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
AC04-94AL85000
OSTI ID:
1431289
Report Number(s):
SAND-2016-3865J; 638710
Journal Information:
Emerging Infectious Diseases, Vol. 22, Issue 9; ISSN 1080-6040
Publisher:
Centers for Disease Control and PreventionCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 28 works
Citation information provided by
Web of Science

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Cited By (16)

The Ebola virus disease outbreak in Tonkolili district, Sierra Leone: a retrospective analysis of the Viral Haemorrhagic Fever surveillance system, July 2014–June 2015 journal January 2019
Case Fatality Ratio Estimates for the 2013–2016 West African Ebola Epidemic: Application of Boosted Regression Trees for Imputation journal July 2019
Heterogeneities in the case fatality ratio in the West African Ebola outbreak 2013–2016 journal April 2017
Key data for outbreak evaluation: building on the Ebola experience journal April 2017
A meta-analysis of clinical studies conducted during the West Africa Ebola virus disease outbreak confirms the need for randomized control groups journal November 2019
Surviving Ebola: A historical cohort study of Ebola mortality and survival in Sierra Leone 2014-2015 journal December 2018
Reporting quality of the 2014 Ebola outbreak in Africa: A systematic analysis journal June 2019
Exploratory investigation of region level risk factors of Ebola Virus Disease in West Africa journal January 2018
Case Fatality Ratio Estimates for the 2013-2016 West African Ebola Epidemic: Application of Boosted Regression Trees for Imputation text January 2018
Exploratory investigation of region level risk factors of Ebola virus disease in West Africa posted_content August 2018
Exploratory investigation of region level risk factors of Ebola virus disease in West Africa posted_content August 2018
Case fatality ratio estimates for the 2013–2016 West African Ebola epidemic: application of Boosted Regression Trees for imputation journal February 2019
Case fatality ratio estimates for the 2013 – 2016 West African Ebola epidemic: application of Boosted Regression Trees for imputation. text January 2018
Ebola and Public Authority: Saving Loved Ones in Sierra Leone journal May 2019
Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates journal August 2017
Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics journal January 2020

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