Recent Advances in Nanomaterials for Gene Delivery—A Review

Riley, II, Michael K.; Vermerris, Wilfred

doi:10.3390/nano7050094

Title: Recent Advances in Nanomaterials for Gene Delivery—A Review

Journal Article · Fri Apr 28 00:00:00 EDT 2017 · Nanomaterials

DOI:https://doi.org/10.3390/nano7050094· OSTI ID:1426434

Riley, II, Michael K. ^[1]; Vermerris, Wilfred ^[1]

Univ. of Florida, Gainesville, FL (United States)

With the rapid development of nanotechnology in the recent decade, novel DNA and RNA delivery systems for gene therapy have become available that can be used instead of viral vectors. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, protein and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have as advantages over viral vectors a decreased immune response, and additionally offer flexibility in design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. The focus of this review is to provide an overview of novel nanotechnology-based methods to deliver DNA and small interfering RNAs into biological systems.

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Research Organization:: Univ. of Florida, Gainesville, FL (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Bioenergy Technologies Office; USDOE Office of International Affairs (IA)

Grant/Contract Number:: PI0000031

OSTI ID:: 1426434

Alternate ID(s):: OSTI ID: 1767999

Journal Information:: Nanomaterials, Vol. 7, Issue 12; ISSN 2079-4991

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 219 works

Citation information provided by
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