Aging Exacerbates Neuroinflammatory Outcomes Induced by Acute Ozone Exposure

Tyler, Christina R.; Noor, Shahani; Young, Tamara; Rivero, Valeria; Sanchez, Bethany; Lucas, Selita; Caldwell, Kevin K.; Milligan, Erin D.; Campen, Matthew J.

doi:10.1093/toxsci/kfy014

Title: Aging Exacerbates Neuroinflammatory Outcomes Induced by Acute Ozone Exposure

Journal Article · Sat Jan 27 00:00:00 EST 2018 · Toxicological Sciences

DOI:https://doi.org/10.1093/toxsci/kfy014· OSTI ID:1419764

Tyler, Christina R. ^[1]; Noor, Shahani ^[2]; Young, Tamara ^[3]; Rivero, Valeria ^[3]; Sanchez, Bethany ^[3]; Lucas, Selita ^[3]; Caldwell, Kevin K. ^[2]; Milligan, Erin D. ^[2]; Campen, Matthew J. ^[3]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of New Mexico, Albuquerque, NM (United States)
Univ. of New Mexico Health Sciences Center, Albuquerque, NM (United States)
Univ. of New Mexico, Albuquerque, NM (United States)

The role of environmental stressors, particularly exposure to air pollution, in the development of neurodegenerative disease remains underappreciated. We examined the neurological effects of acute ozone (O₃) exposure in aged mice, where increased blood brain barrier (BBB) permeability may confer vulnerability to neuroinflammatory outcomes. C₅₇BL/6 male mice, aged 8-10 weeks or 12–18 months were exposed to either filtered air (FA) or 1.0 ppm O₃ for 4 hours; animals received a single IP injection of sodium fluorescein (FSCN) 20 hours post-exposure. One-hour post-FSCN injection, animals were transcardially perfused for immunohistochemical analysis of BBB permeability. β-amyloid protein expression was assessed via ELISA. Flow cytometric characterization of infiltrating immune cells, including neutrophils, macrophages, and microglia populations was performed 20 hours post-O₃ exposure. Flow cytometry analysis of brains revealed increased microglia “activation” and presentation of CD11b, F4/80 and MHCII in aged animals relative to younger ones; these age-induced differences were potentiated by acute O₃ exposure. Cortical and limbic regions in aged brains had increased reactive microgliosis and β-amyloid protein expression after O₃ insult. The aged cerebellum was particularly vulnerable to acute O₃ exposure with increased populations of infiltrating neutrophils, peripheral macrophages/monocytes, and Ly6C⁺ inflammatory monocytes after insult, which were not significantly increased in the young cerebellum. O₃ exposure increased the penetration of FSCN beyond the BBB, the infiltration of peripheral immune cells, and reactive gliosis of microglia. Furthermore, the aged BBB is vulnerable to insult and becomes highly penetrable in response to O₃ exposure, leading to greater neuroinflammatory outcomes.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1419764

Report Number(s):: LA-UR-18-20155

Journal Information:: Toxicological Sciences, Vol. 163, Issue 1; ISSN 1096-6080

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 27 works

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60 APPLIED LIFE SCIENCES
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ozone
blood–brain barrier
inhalation toxicology
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