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Title: Filtration device for rapid separation of biological particles from complex matrices

Patent ·
OSTI ID:1416743
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Methods and systems for filtering of biological particles are disclosed. Filtering membranes separate adjacent chambers. Through osmotic or electrokinetic processes, flow of particles is carried out through the filtering membranes. Cells, viruses and cell waste can be filtered depending on the size of the pores of the membrane. A polymer brush can be applied to a surface of the membrane to enhance filtering and prevent fouling.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-07NA27344
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Number(s):
9,861,939
Application Number:
14/874,326
OSTI ID:
1416743
Resource Relation:
Patent File Date: 2015 Oct 02
Country of Publication:
United States
Language:
English

References (8)

Virus-removing bag and virus-removing method using the same patent-application March 2006
System, method and apparatus for purifying biological fluids such as blood and constituents thereof patent-application May 2011
Magnetically Responsive Membranes patent-application August 2014
Biocompatible hydrogel polymer matrix for delivery of cells patent-application September 2014
Capture and alignment of phi29 viral particles in sub-40 nanometer porous alumina membranes journal September 2008
Continuous dielectrophoretic bacterial separation and concentration from physiological media of high conductivity journal January 2011
Rapid detection of bacterial cell from whole blood: Integration of DNA sample preparation into single micro-PCR chip journal May 2011
Development of a virus concentration method using lanthanum-based chemical flocculation coupled with modified membrane filtration procedures journal June 2013

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