Measurements of carbon-14 with cavity ring-down spectroscopy

McCartt, A. D.; Ognibene, T.; Bench, G.; Turteltaub, K.

doi:10.1016/j.nimb.2015.05.036

Title: Measurements of carbon-14 with cavity ring-down spectroscopy

Journal Article · Sat Jun 13 00:00:00 EDT 2015 · Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms

DOI:https://doi.org/10.1016/j.nimb.2015.05.036· OSTI ID:1409931

McCartt, A. D. ^[1]; Ognibene, T. ^[1]; Bench, G. ^[1]; Turteltaub, K. ^[1]

Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Accelerator Mass Spectrometry (AMS) is the most sensitive method for quantitation of ¹⁴C in biological samples. This technology has been used in a variety of low dose, human health related studies over the last 20 years when very high sensitivity was needed. AMS helped pioneer these scientific methods, but its expensive facilities and requirements for highly trained technical staff have limited their proliferation. Quantification of ¹⁴C by cavity ring-down spectroscopy (CRDS) offers an approach that eliminates many of the shortcomings of an accelerator-based system and would supplement the use of AMS in biomedical research. Our initial prototype, using a non-ideal wavelength laser and under suboptimal experimental conditions, has a 3.5-modern, 1-σ precision for detection of milligram-sized, carbon-14-elevated samples. Furthermore, these results demonstrate proof of principle and provided a starting point for the development of a spectrometer capable of biologically relevant sensitivities.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1409931

Report Number(s):: LLNL-CONF-740906; PII: S0168583X15005315

Journal Information:: Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms, Vol. 361, Issue C; Conference: Presented at: Accelerator Mass Spectrometry 13, Aix en Provence (France), 14-20 Aug 2014; ISSN 0168-583X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 16 works

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References (9)

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Laser-based radiocarbon detection in the laboratory: How soon? Murnick, Daniel E. Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, Issue 11 https://doi.org/10.1002/jlcr.3794	journal	August 2019
A cavity ring-down spectrometer for study of biomedical radiocarbon-labeled samples Sonnenschein, Volker; Terabayashi, Ryohei; Tomita, Hideki Journal of Applied Physics, Vol. 124, Issue 3 https://doi.org/10.1063/1.5041015	journal	July 2018
Intracavity optogalvanic detection of ¹⁴ C using a stabilized ¹⁴ CO ₂ laser Murnick, D. E.; DeGuzman, M.; Thompson, Joshua Journal of Applied Physics, Vol. 126, Issue 9 https://doi.org/10.1063/1.5108963	journal	September 2019
Spectroscopic detection of radiocarbon dioxide at parts-per-quadrillion sensitivity Galli, Iacopo; Bartalini, Saverio; Ballerini, Riccardo Optica, Vol. 3, Issue 4 https://doi.org/10.1364/optica.3.000385	journal	January 2016
Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science Malfatti, Michael A.; Buchholz, Bruce A.; Enright, Heather A. Toxics, Vol. 7, Issue 2 https://doi.org/10.3390/toxics7020027	journal	May 2019
The HITRAN 2004 molecular spectroscopic database Rothman, L. S.; Jacquemart, D.; Barbe, A. Journal of Quantitative Spectroscopy and Radiative Transfer, Vol. 96, Issue 2 https://doi.org/10.1016/j.jqsrt.2004.10.008	journal	December 2005
The HITRAN2016 molecular spectroscopic database Gordon, I. E.; Rothman, L. S.; Hill, C. Journal of Quantitative Spectroscopy and Radiative Transfer, Vol. 203 https://doi.org/10.1016/j.jqsrt.2017.06.038	journal	December 2017

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