Flagellin peptide flg22 gains access to long-distance trafficking in Arabidopsis via its receptor, FLS2

Jelenska, Joanna; Davern, Sandra M.; Standaert, Robert F.; Mirzadeh, Saed; Greenberg, Jean T.

doi:10.1093/jxb/erx060

Title: Flagellin peptide flg22 gains access to long-distance trafficking in Arabidopsis via its receptor, FLS2

Journal Article · Wed Mar 01 00:00:00 EST 2017 · Journal of Experimental Botany

DOI:https://doi.org/10.1093/jxb/erx060· OSTI ID:1394455

Jelenska, Joanna ^[1]; Davern, Sandra M. ^[2]; Standaert, Robert F. ^[3]; Mirzadeh, Saed ^[2]; Greenberg, Jean T. ^[1]

Univ. of Chicago, IL (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)

Diverse pathogen-derived molecules, such as bacterial flagellin and its conserved peptide flg22, are recognized in plants via plasma membrane receptors and induce both local and systemic immune responses. The fate of such ligands was unknown: whether and by what mechanism(s) they enter plant cells and whether they are transported to distal tissues. We used biologically active fluorophore and radiolabeled peptides to establish that flg22 moves to distal organs with the closest vascular connections. Remarkably, entry into the plant cell via endocytosis together with the FLS2 receptor is needed for delivery to vascular tissue and long-distance transport of flg22. This contrasts with known routes of long distance transport of other non-cell-permeant molecules in plants, which require membrane-localized transporters for entry to vascular tissue. Thus, a plasma membrane receptor acts as a transporter to enable access of its ligand to distal trafficking routes.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1394455

Journal Information:: Journal of Experimental Botany, Vol. 68, Issue 7; ISSN 0022-0957

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 26 works

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