APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

Risacher, Shannon L.; Kim, Sungeun; Nho, Kwangsik; Foroud, Tatiana; Shen, Li; Petersen, Ronald C.; Jack, Clifford R.; Beckett, Laurel A.; Aisen, Paul S.; Koeppe, Robert A.; Jagust, William J.; Shaw, Leslie M.; Trojanowski, John Q.; Weiner, Michael W.; Saykin, Andrew J.

doi:10.1016/j.jalz.2015.03.003

Title: APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

Journal Article · Thu May 07 00:00:00 EDT 2015 · Alzheimer's & Dementia

DOI:https://doi.org/10.1016/j.jalz.2015.03.003· OSTI ID:1378678

Risacher, Shannon L. ^[1]; Kim, Sungeun ^[2]; Nho, Kwangsik ^[2]; Foroud, Tatiana ^[3]; Shen, Li ^[2]; Petersen, Ronald C. ^[4]; Jack, Clifford R. ^[5]; Beckett, Laurel A. ^[6]; Aisen, Paul S. ^[7]; Koeppe, Robert A. ^[8]; Jagust, William J. ^[9]; Shaw, Leslie M. ^[10]; Trojanowski, John Q. ^[10]; Weiner, Michael W. ^[11]; Saykin, Andrew J. ^[12]

Indiana Univ., Indianapolis, IN (United States). School of Medicine, Dept. of Radiology and Imaging Sciences, Center for Neuroimaging; Indiana Univ., Indianapolis, IN (United States). School of Medicine, Indiana Alzheimer Disease Center
Indiana Univ., Indianapolis, IN (United States). School of Medicine, Dept. of Radiology and Imaging Sciences, Center for Neuroimaging; Indiana Univ., Indianapolis, IN (United States). School of Medicine, Indiana Alzheimer Disease Center; Indiana Univ., Indianapolis, IN (United States). School of Medicine, Center for Computational Biology and Bioinformatics
Indiana Univ., Indianapolis, IN (United States). School of Medicine, Indiana Alzheimer Disease Center; Indiana Univ., Indianapolis, IN (United States). School of Medicine, Dept. of Medical and Molecular Genetics
Mayo Clinic, Rochester, MN (United States). Dept. of Neurology
Mayo Clinic, Rochester, MN (United States). Dept. of Radiology
Univ. of California, Davis, CA (United States). Dept. of Public Health Sciences, Division of Biostatistics
Univ. of California, San Diego, CA (United States). Dept. of Neurology
Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Radiology
Univ. of California, Berkeley, CA (United States). Dept. of Neurology
Univ. of Pennsylvania, Philadelphia, PA (United States). School of Medicine, Dept. of Pathology and Lab. Medicine
Univ. of California, San Francisco, CA (United States). Dept. of Radiology, Medicine and Psychiatry; Dept. of Veterans Affairs Medical Center, San Francisco, CA (United States)
Indiana Univ., Indianapolis, IN (United States). School of Medicine, Dept. of Radiology and Imaging Sciences, Center for Neuroimaging; Indiana Univ., Indianapolis, IN (United States). School of Medicine, Indiana Alzheimer Disease Center; Indiana Univ., Indianapolis, IN (United States). School of Medicine, Center for Computational Biology and Bioinformatics; Indiana Univ., Indianapolis, IN (United States). School of Medicine, Dept. of Medical and Molecular Genetics

This study assessed apolipoprotein E (APOE) ε4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal older adults with significant memory concerns (SMC). Cognitively normal, SMC, and early mild cognitive impairment participants from Alzheimer's Disease Neuroimaging Initiative were divided by APOE ε4 carrier status. Diagnostic and APOE effects were evaluated with emphasis on SMC. Additional analyses in SMC evaluated the effect of the interaction between APOE and [¹⁸F]Florbetapir amyloid positivity on CSF biomarkers. SMC ε4+ showed greater amyloid deposition than SMC ε4-, but no hypometabolism or medial temporal lobe (MTL) atrophy. SMC ε4+ showed lower amyloid beta 1-42 and higher tau/p-tau than ε4-, which was most abnormal in APOE ε4+ and cerebral amyloid positive SMC. Lastly, SMC APOE ε4+ show abnormal changes in amyloid and tau biomarkers, but no hypometabolism or MTL neurodegeneration, reflecting the at-risk nature of the SMC group and the importance of APOE in mediating this risk.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: AC02-05CH11231; U01 AG024904; W81XWH-12-2-0012; P30 AG010129; K01 AG030514

OSTI ID:: 1378678

Journal Information:: Alzheimer's & Dementia, Vol. 11, Issue 12; ISSN 1552-5260

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 124 works

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The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk Fan, Jialing; Tao, Wuhai; Li, Xin International Journal of Molecular Sciences, Vol. 20, Issue 5 https://doi.org/10.3390/ijms20051177	journal	March 2019

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60 APPLIED LIFE SCIENCES
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SMC
Subjective cognitive decline
SCD
Apolipoprotein E
APOE
Neuroimaging
[18F]Florbetapir PET
[18F]Fluorodeoxyglucose
FDG
PET
Structural magnetic resonance imaging (MRI)
Cerebrospinal fluid
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Title: APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

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