Is amyloid-β harmful to the brain? Insights from human imaging studies

Jagust, William

doi:10.1093/brain/awv326

Title: Is amyloid-β harmful to the brain? Insights from human imaging studies

Journal Article · Thu Nov 26 00:00:00 EST 2015 · Brain

DOI:https://doi.org/10.1093/brain/awv326· OSTI ID:1378658

Jagust, William ^[1]

Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Inst.

Although the amyloid-β protein associated with the Alzheimer’s disease plaque has been detectable in living people for over a decade, its importance in the pathogenesis of Alzheimer’s disease is still debated. The frequent presence of amyloid-β in the brains of cognitively healthy older people has been interpreted as evidence against a causative role. If amyloid-β is crucial to the development of Alzheimer’s disease, it should be associated with other Alzheimer’s disease-like neurological changes. Here, this review examines whether amyloid-β is associated with other biomarkers indicative of early Alzheimer’s disease in normal older people. The preponderance of evidence links amyloid-β to functional change, progressive brain atrophy, and cognitive decline. Individuals at greatest risk of decline seem to be those with evidence of both amyloid-β and findings suggestive of neurodegeneration. Lastly, the crucial question is thus how amyloid-β is related to brain degeneration and how these two processes interact to cause cognitive decline and dementia.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: AC02-05CH11231; AG034570

OSTI ID:: 1378658

Journal Information:: Brain, Vol. 139, Issue 1; ISSN 0006-8950

Country of Publication:: United States

Language:: English

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Cited by: 72 works

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