Sequential self-assembly of DNA functionalized droplets

Zhang, Yin; McMullen, Angus; Pontani, Lea-Laetitia; He, Xiaojin; Sha, Ruojie; Seeman, Nadrian C.; Brujic, Jasna; Chaikin, Paul M.

doi:10.1038/s41467-017-00070-0

Title: Sequential self-assembly of DNA functionalized droplets

Journal Article · Fri Jun 16 00:00:00 EDT 2017 · Nature Communications

DOI:https://doi.org/10.1038/s41467-017-00070-0· OSTI ID:1374562

Zhang, Yin ^[1]; McMullen, Angus ^[2]; Pontani, Lea-Laetitia ^[2]; He, Xiaojin ^[2]; Sha, Ruojie ^[3]; Seeman, Nadrian C. ^[3]; Brujic, Jasna ^[2]; Chaikin, Paul M. ^[2]

Univ. Pierre et Marie Curie, Paris (France). Inst. of Nanosciences Paris; New York Univ. (NYU), NY (United States). Center for Soft Matter Research
New York Univ. (NYU), NY (United States). Center for Soft Matter Research
New York Univ. (NYU), NY (United States). Chemistry Dept.

Complex structures and devices, both natural and manmade, are often constructed sequentially. From crystallization to embryogenesis, a nucleus or seed is formed and built upon. Sequential assembly allows for initiation, signaling, and logical programming, which are necessary for making enclosed, hierarchical structures. Though biology relies on such schemes, they have not been available in materials science. We demonstrate programmed sequential self-assembly of DNA functionalized emulsions. The droplets are initially inert because the grafted DNA strands are pre-hybridized in pairs. Active strands on initiator droplets then displace one of the paired strands and thus release its complement, which in turn activates the next droplet in the sequence, akin to living polymerization. This strategy provides time and logic control during the self-assembly process, and offers a new perspective on the synthesis of materials.

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Research Organization:: New York Univ. (NYU), NY (United States); Energy Frontier Research Centers (EFRC) (United States). Center for Bio-Inspired Energy Science (CBES)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0007991

OSTI ID:: 1374562

Journal Information:: Nature Communications, Vol. 8, Issue 1; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 49 works

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