Inference of Transmission Network Structure from HIV Phylogenetic Trees
[1];
[2];
[3];
- Stockholm Univ. (Sweden). Dept. of Mathematics; Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Karolinska Inst., Stockholm (Sweden). Dept. of Microbiology, Tumor and Cell Biology; Karolinska Univ. Hospital, Stockholm (Sweden)
- Stockholm Univ. (Sweden). Dept. of Mathematics
Phylogenetic inference is an attractive means to reconstruct transmission histories and epidemics. However, there is not a perfect correspondence between transmission history and virus phylogeny. Both node height and topological differences may occur, depending on the interaction between within-host evolutionary dynamics and between-host transmission patterns. To investigate these interactions, we added a within-host evolutionary model in epidemiological simulations and examined if the resulting phylogeny could recover different types of contact networks. To further improve realism, we also introduced patient-specific differences in infectivity across disease stages, and on the epidemic level we considered incomplete sampling and the age of the epidemic. Second, we implemented an inference method based on approximate Bayesian computation (ABC) to discriminate among three well-studied network models and jointly estimate both network parameters and key epidemiological quantities such as the infection rate. Our ABC framework used both topological and distance-based tree statistics for comparison between simulated and observed trees. Overall, our simulations showed that a virus time-scaled phylogeny (genealogy) may be substantially different from the between-host transmission tree. This has important implications for the interpretation of what a phylogeny reveals about the underlying epidemic contact network. In particular, we found that while the within-host evolutionary process obscures the transmission tree, the diversification process and infectivity dynamics also add discriminatory power to differentiate between different types of contact networks. We also found that the possibility to differentiate contact networks depends on how far an epidemic has progressed, where distance-based tree statistics have more power early in an epidemic. Finally, we applied our ABC inference on two different outbreaks from the Swedish HIV-1 epidemic.
- Research Organization:
- Stockholm Univ. (Sweden); Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE; National Inst. of Health (NIH) (United States); Swedish Research Council (SRC)
- Contributing Organization:
- Karolinska Inst., Stockholm (Sweden); Karolinska Univ. Hospital, Stockholm (Sweden)
- Grant/Contract Number:
- AC52-06NA25396; R01AI087520; 340-2013-5003
- OSTI ID:
- 1360708
- Report Number(s):
- LA-UR-16-27500
- Journal Information:
- PLoS Computational Biology (Online), Vol. 13, Issue 1; ISSN 1553-7358
- Publisher:
- Public Library of ScienceCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
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