High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

Larsson, Daniel H.; Vågberg, William; Yaroshenko, Andre; Yildirim, Ali Ãnder; Hertz, Hans M.

doi:10.1038/srep39074

Title: High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

Journal Article · Tue Dec 13 00:00:00 EST 2016 · Scientific Reports

DOI:https://doi.org/10.1038/srep39074· OSTI ID:1352154

Larsson, Daniel H. ^[1]; Vågberg, William ^[2]; Yaroshenko, Andre ^[3]; Yildirim, Ali Ãnder ^[4]; Hertz, Hans M. ^[2]

KTH Royal Institute of Technology/Albanova, Stockholm (Sweden); Stanford Univ., Stanford, CA (United States)
KTH Royal Institute of Technology/Albanova, Stockholm (Sweden)
Technische Univ. Munchen, Garching (Germany)
Helmholtz Zentrum Munchen, Neuherberg (Germany)

X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-power small-spot liquid-metal-jet electron-impact source. Lastly, the tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.

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Research Organization:: SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 1352154

Journal Information:: Scientific Reports, Vol. 6, Issue 1; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 30 works

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