Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

Messaoudi, Ilhem; Amarasinghe, Gaya K.; Basler, Christopher F.

doi:10.1038/nrmicro3524

Title: Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

Journal Article · Tue Oct 06 00:00:00 EDT 2015 · Nature Reviews Microbiology

DOI:https://doi.org/10.1038/nrmicro3524· OSTI ID:1351402

Messaoudi, Ilhem ^[1]; Amarasinghe, Gaya K. ^[2]; Basler, Christopher F. ^[3]

Univ. of California, Riverside, CA (United States)
Washington Univ., St. Louis, MO (United States)
Icahn School of Medicine at Mount Sinai, New York, NY (United States)

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. Here, in this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: U.S. Department of Defense and the Defense Threat Reduction Agency; National Institutes of Health (NIH)

Grant/Contract Number:: U19 AI109945; R01 AI059536; U19 AI109664; U19 AI070489; R01 AI081914; HDTRA1-12-1-0051; HDTRA1-14-1-0013

OSTI ID:: 1351402

Journal Information:: Nature Reviews Microbiology, Vol. 13, Issue 11; ISSN 1740-1526

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 155 works

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