A multi-scale approach to designing therapeutics for tuberculosis

Linderman, Jennifer J.; Cilfone, Nicholas A.; Pienaar, Elsje; Gong, Chang; Kirschner, Denise E.

doi:10.1039/c4ib00295d

Title: A multi-scale approach to designing therapeutics for tuberculosis

Journal Article · Mon Apr 20 00:00:00 EDT 2015 · Integrative Biology

DOI:https://doi.org/10.1039/c4ib00295d· OSTI ID:1346971

Linderman, Jennifer J. ^[1]; Cilfone, Nicholas A. ^[1]; Pienaar, Elsje ^[2]; Gong, Chang ^[1]; Kirschner, Denise E. ^[3]

Univ. of Michigan, Ann Arbor, MI (United States)
Univ. of Michigan, Ann Arbor, MI (United States); Univ. of Michigan Medical School, Ann Arbor, MI (United States)
Univ. of Michigan Medical School, Ann Arbor, MI (United States)

Approximately one third of the world’s population is infected with Mycobacterium tuberculosis. Limited information about how the immune system fights M. tuberculosis and what constitutes protection from the bacteria impact our ability to develop effective therapies for tuberculosis. We present an in vivo systems biology approach that integrates data from multiple model systems and over multiple length and time scales into a comprehensive multi-scale and multi-compartment view of the in vivo immune response to M. tuberculosis. Lastly, we describe computational models that can be used to study (a) immunomodulation with the cytokines tumor necrosis factor and interleukin 10, (b) oral and inhaled antibiotics, and (c) the effect of vaccination.

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Research Organization:: Univ. of California, Oakland, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1346971

Journal Information:: Integrative Biology, Vol. 7, Issue 5; ISSN 1757-9694

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 22 works

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