Synthesis and use of 2-[18F]fluoromalondialdehyde, an accessible synthon for bioconjugation
- Massachusetts General Hospital, Boston, MA (United States)
We proposed methods for the synthesis and purification of 2-[18F]fluoromalondialdehyde, which will be a readily accessible synthon for bioconjugation. Our achievements in these areas will specifically address a stated goal of the DOE providing a transformational technology for macromolecule radiolabeling. Accomplishment of our aims will serve both DOE mission-related research as well as nuclear medicine research supported by the NIH and industry. At the heart of our proposal is the aim to “improve synthetic methodology for rapidly and efficiently incorporating radionuclides into a wide range of organic compounds.”
- Research Organization:
- Massachusetts General Hospital, Boston, MA (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- DOE Contract Number:
- SC0011947
- OSTI ID:
- 1346940
- Report Number(s):
- DOE-MGH-0011947
- Country of Publication:
- United States
- Language:
- English
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