Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets

Griswold, J. R.; Medvedev, D. G.; Engle, J. W.; Copping, R.; Fitzsimmons, J. M.; Radchenko, V.; Cooley, J. C.; Fassbender, M. E.; Denton, D. L.; Murphy, K. E.; Owens, A. C.; Birnbaum, E. R.; John, K. D.; Nortier, F. M.; Stracener, D. W.; Heilbronn, L. H.; Mausner, L. F.; Mirzadeh, S.

doi:10.1016/j.apradiso.2016.09.026

Title: Large scale accelerator production of ²²⁵Ac: Effective cross sections for 78–192 MeV protons incident on ²³²Th targets

Journal Article · Wed Sep 28 00:00:00 EDT 2016 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2016.09.026· OSTI ID:1346748

Griswold, J. R. ^[1]; Medvedev, D. G. ^[2]; Engle, J. W. ^[3]; Copping, R. ^[4]; Fitzsimmons, J. M. ^[2]; Radchenko, V. ^[3]; Cooley, J. C. ^[3]; Fassbender, M. E. ^[3]; Denton, D. L. ^[4]; Murphy, K. E. ^[4]; Owens, A. C. ^[4]; Birnbaum, E. R. ^[3]; John, K. D. ^[3]; Nortier, F. M. ^[3]; Stracener, D. W. ^[4]; Heilbronn, L. H. ^[5]; Mausner, L. F. ^[2]; Mirzadeh, S. ^[4]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
Brookhaven National Lab. (BNL), Upton, NY (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States)

Actinium-225 and ²¹³Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of ²²⁵Ac. The high energy proton spallation reaction on natural thorium metal target has been utilized to produce millicurie quantities of ²²⁵Ac. The results of sixteen irradiation experiments of Th metal at beam energies between 78 and 200 MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL). Excitation functions for actinium and thorium isotopes as well as for some of the fission products are presented. The cross sections for production of ²²⁵Ac range from 3.6 to 16.7 mb in the incident proton energy range of 78 to 192 MeV. Based on these data, production of Curie quantities of 225Ac is possible by irradiating a 5.0 g cm^-2232Th target for 10 days in either BNL or LANL proton irradiation facilities.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: SC00112704; AC05-00OR22725; AC0500OR22725

OSTI ID:: 1346748

Alternate ID(s):: OSTI ID: 1333066; OSTI ID: 1397588

Report Number(s):: BNL-113608-2017-JA; R&D Project: KBCH139; KB0202011; TRN: US1701601

Journal Information:: Applied Radiation and Isotopes, Vol. 118, Issue C; ISSN 0969-8043

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 53 works

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Development of Targeted Alpha Particle Therapy for Solid Tumors Tafreshi, Narges K.; Doligalski, Michael L.; Tichacek, Christopher J. Molecules, Vol. 24, Issue 23 https://doi.org/10.3390/molecules24234314	journal	November 2019
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Title: Large scale accelerator production of 225Ac: Effective cross sections for 78–192 MeV protons incident on 232Th targets

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