Lead(II) complex formation with l-cysteine in aqueous solution

Jalilehvand, Farideh; Sisombath, Natalie S.; Schell, Adam C.; Facey, Glenn A.

doi:10.1021/ic5025668

Title: Lead(II) complex formation with l-cysteine in aqueous solution

Journal Article · Thu Feb 19 00:00:00 EST 2015 · Inorganic Chemistry

DOI:https://doi.org/10.1021/ic5025668· OSTI ID:1345620

Jalilehvand, Farideh ^[1]; Sisombath, Natalie S. ^[1]; Schell, Adam C. ^[1]; Facey, Glenn A. ^[2]

Univ. of Calgary, Calgary, AB (Canada)
Univ. of Ottawa, Ottawa, ON (Canada)

The lead(II) complexes formed with the multidentate chelator l-cysteine (H₂Cys) in an alkaline aqueous solution were studied using ²⁰⁷Pb, ¹³C, and ¹H NMR, Pb L_III-edge X-ray absorption, and UV–vis spectroscopic techniques, complemented by electrospray ion mass spectrometry (ESI-MS). The H₂Cys/Pb^II mole ratios were varied from 2.1 to 10.0 for two sets of solutions with C_Pb^II = 0.01 and 0.1 M, respectively, prepared at pH values (9.1–10.4) for which precipitates of lead(II) cysteine dissolved. At low H₂Cys/Pb^II mole ratios (2.1–3.0), a mixture of the dithiolate [Pb(S,N-Cys)₂]^2– and [Pb(S,N,O-Cys)(S-HCys)]^– complexes with average Pb–(N/O) and Pb–S distances of 2.42 ± 0.04 and 2.64 ± 0.04 Å, respectively, was found to dominate. At high concentration of free cysteinate (>0.7 M), a significant amount converts to the trithiolate [Pb(S,N-Cys)(S-HCys)₂]^2–, including a minor amount of a PbS₃-coordinated [Pb(S-HCys)₃]^– complex. The coordination mode was evaluated by fitting linear combinations of EXAFS oscillations to the experimental spectra and by examining the ²⁰⁷Pb NMR signals in the chemical shift range δ_Pb = 2006–2507 ppm, which became increasingly deshielded with increasing free cysteinate concentration. One-pulse magic-angle-spinning (MAS) ²⁰⁷Pb NMR spectra of crystalline Pb(aet)₂ (Haet = 2-aminoethanethiol or cysteamine) with PbS₂N₂ coordination were measured for comparison (δ_iso = 2105 ppm). The UV–vis spectra displayed absorption maxima at 298–300 nm (S^– → Pb^II charge transfer) for the dithiolate PbS₂N(N/O) species; with increasing ligand excess, a shoulder appeared at ~330 nm for the trithiolate PbS₃N and PbS₃ (minor) complexes. Finally, the results provide spectroscopic fingerprints for structural models for lead(II) coordination modes to proteins and enzymes.

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Research Organization:: Univ. of Calgary, Calgary, AB (Canada)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 1345620

Journal Information:: Inorganic Chemistry, Vol. 54, Issue 5; ISSN 0020-1669

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 48 works

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