Expanding the eukaryotic genetic code
Abstract
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
- Inventors:
- Publication Date:
- Research Org.:
- The Scripps Reserach Institute, La Jolla, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1345382
- Patent Number(s):
- 9,580,721
- Application Number:
- 14/574,257
- Assignee:
- The Scripps Reserach Institute
- DOE Contract Number:
- FG03-00ER45812
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Dec 17
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Chin, Jason W., Cropp, T. Ashton, Anderson, J. Christopher, and Schultz, Peter G. Expanding the eukaryotic genetic code. United States: N. p., 2017.
Web.
Chin, Jason W., Cropp, T. Ashton, Anderson, J. Christopher, & Schultz, Peter G. Expanding the eukaryotic genetic code. United States.
Chin, Jason W., Cropp, T. Ashton, Anderson, J. Christopher, and Schultz, Peter G. 2017.
"Expanding the eukaryotic genetic code". United States. https://www.osti.gov/servlets/purl/1345382.
@article{osti_1345382,
title = {Expanding the eukaryotic genetic code},
author = {Chin, Jason W. and Cropp, T. Ashton and Anderson, J. Christopher and Schultz, Peter G.},
abstractNote = {This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.},
doi = {},
url = {https://www.osti.gov/biblio/1345382},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 28 00:00:00 EST 2017},
month = {Tue Feb 28 00:00:00 EST 2017}
}
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