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Title: Expanding the eukaryotic genetic code

Abstract

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

Inventors:
; ; ;
Publication Date:
Research Org.:
The Scripps Reserach Institute, La Jolla, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1345382
Patent Number(s):
9,580,721
Application Number:
14/574,257
Assignee:
The Scripps Reserach Institute
DOE Contract Number:  
FG03-00ER45812
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Dec 17
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Chin, Jason W., Cropp, T. Ashton, Anderson, J. Christopher, and Schultz, Peter G. Expanding the eukaryotic genetic code. United States: N. p., 2017. Web.
Chin, Jason W., Cropp, T. Ashton, Anderson, J. Christopher, & Schultz, Peter G. Expanding the eukaryotic genetic code. United States.
Chin, Jason W., Cropp, T. Ashton, Anderson, J. Christopher, and Schultz, Peter G. 2017. "Expanding the eukaryotic genetic code". United States. https://www.osti.gov/servlets/purl/1345382.
@article{osti_1345382,
title = {Expanding the eukaryotic genetic code},
author = {Chin, Jason W. and Cropp, T. Ashton and Anderson, J. Christopher and Schultz, Peter G.},
abstractNote = {This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.},
doi = {},
url = {https://www.osti.gov/biblio/1345382}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 28 00:00:00 EST 2017},
month = {Tue Feb 28 00:00:00 EST 2017}
}

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