Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance
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journal
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February 2016 |
Modulation of Human Immunodeficiency Virus Type 1 Protease Autoprocessing by Charge Properties of Surface Residue 69
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journal
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May 2009 |
Insights into amprenavir resistance in E35D HIV-1 protease mutation from molecular dynamics and binding free-energy calculations
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journal
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June 2006 |
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
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journal
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May 1997 |
Mutational and Structural Studies Aimed at Characterizing the Monomer of HIV-1 Protease and Its Precursor
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journal
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April 2007 |
Highly resistant HIV-1 proteases and strategies for their inhibition
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journal
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June 2015 |
Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease
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journal
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December 2009 |
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
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journal
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July 1999 |
Likelihood-enhanced fast rotation functions
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journal
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February 2004 |
Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir
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journal
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August 2008 |
Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy
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journal
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January 2014 |
Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir
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journal
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January 2007 |
Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114
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journal
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October 2006 |
Measurement of 15N relaxation rates in perdeuterated proteins by TROSY-based methods
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journal
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June 2012 |
Evolution under Drug Pressure Remodels the Folding Free-Energy Landscape of Mature HIV-1 Protease
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journal
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July 2016 |
Binding Kinetics of Darunavir to Human Immunodeficiency Virus Type 1 Protease Explain the Potent Antiviral Activity and High Genetic Barrier
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journal
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October 2007 |
Conformational variation of an extreme drug resistant mutant of HIV protease
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journal
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November 2015 |
HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements
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journal
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March 2012 |
HIV-1 Protease: Structural Perspectives on Drug Resistance
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journal
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December 2009 |
Interaction of I50V Mutant and I50L/A71V Double Mutant HIV-Protease with Inhibitor TMC114 (Darunavir): Molecular Dynamics Simulation and Binding Free Energy Studies
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journal
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February 2012 |
The structural biology of HIV assembly
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journal
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April 2008 |
Conformation of Inhibitor-Free HIV-1 Protease Derived from NMR Spectroscopy in a Weakly Oriented Solution
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journal
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December 2014 |
Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro
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journal
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September 2003 |
Rapid structural fluctuations of the free HIV protease flaps in solution: Relationship to crystal structures and comparison with predictions of dynamics calculations
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journal
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February 2002 |
The HIV Type 1 Protease L10I Minor Mutation Decreases Replication Capacity and Confers Resistance to Protease Inhibitors
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journal
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January 2011 |
Likelihood-enhanced fast translation functions
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journal
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March 2005 |
Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme
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journal
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April 2016 |
Predicting protein functions using incomplete hierarchical labels
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journal
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January 2015 |
Improved Cross Validation of a Static Ubiquitin Structure Derived from High Precision Residual Dipolar Couplings Measured in a Drug-Based Liquid Crystalline Phase
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journal
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February 2014 |
Mechanism of Drug Resistance Revealed by the Crystal Structure of the Unliganded HIV-1 Protease with F53L Mutation
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journal
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May 2006 |
Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study
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journal
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October 2011 |
Computational Characterization of Structural Role of the Non-active Site Mutation M36I of Human Immunodeficiency Virus Type 1 Protease
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journal
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July 2007 |
Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights
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text
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January 2015 |
Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: Relevance to drug resistance: Characterization of Group N HIV-1 Protease
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journal
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September 2010 |
Weak alignment NMR: a hawk-eyed view of biomolecular structure
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journal
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October 2005 |
Prediction of HIV drug resistance from genotype with encoded three-dimensional protein structure
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journal
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January 2014 |
Coot model-building tools for molecular graphics
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journal
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November 2004 |
Effectiveness of Nonpeptide Clinical Inhibitor TMC-114 on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V, and L90M
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journal
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February 2006 |
HIV-1 Protease Mutations and Inhibitor Modifications Monitored on a Series of Complexes. Structural Basis for the Effect of the A71V Mutation on the Active Site †
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journal
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September 2006 |
Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease
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journal
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August 2015 |
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site
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journal
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April 2004 |
NMRPipe: A multidimensional spectral processing system based on UNIX pipes
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journal
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November 1995 |
Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters: HIV protease mutants altering hydrophobic clusters
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journal
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August 2010 |
BindingDB Entry 50018356: HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site.
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dataset
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January 2009 |
Sparse Representation for HIV-1 Protease Drug Resistance Prediction
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conference
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May 2013 |
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV
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journal
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April 2009 |
Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights
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journal
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February 2015 |
Conformational flexibility in the flap domains of ligand-free HIV protease
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journal
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July 2007 |
Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1′-Pyrrolidinone or P2-Tris-tetrahydrofuran
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journal
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May 2013 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors
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journal
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May 2011 |
A Comparative Molecular Dynamics, MM–PBSA and Thermodynamic Integration Study of Saquinavir Complexes with Wild-Type HIV-1 PR and L10I, G48V, L63P, A71V, G73S, V82A and I84V Single Mutants
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journal
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February 2013 |
Identification of temperature-sensitive mutants of the human immunodeficiency virus type 1 protease through saturation mutagenesis. Amino acid side chain requirements for temperature sensitivity.
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journal
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March 1994 |