Controlled release of alendronate from nitrogen-doped mesoporous carbon

Saha, Dipendu; Spurri, Amanda; Chen, Jihua; Hensley, Dale K.

doi:10.1016/j.micromeso.2016.04.014

Title: Controlled release of alendronate from nitrogen-doped mesoporous carbon

Journal Article · Wed Apr 13 00:00:00 EDT 2016 · Microporous and Mesoporous Materials

DOI:https://doi.org/10.1016/j.micromeso.2016.04.014· OSTI ID:1319229

Saha, Dipendu ^[1]; Spurri, Amanda ^[1]; Chen, Jihua ^[2]; Hensley, Dale K. ^[2]

Widener Univ., Chester, PA (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

With this study, we have synthesized a nitrogen doped mesoporous carbon with the BET surface area of 1066 m²/g, total pore volume 0.6 cm³/g and nitrogen content of 0.5%. Total alendronate adsorption in this carbon was ~5%. The release experiments were designed in four different media with sequential pH values of 1.2, 4.5, 6.8 and 7.4 for 3, 1, 3 and 5 h, respectively and at 37 °C to imitate the physiological conditions of stomach, duodenum, small intestine and colon, respectively. Release of the drug demonstrated a controlled fashion; only 20% of the drug was released in the media with pH = 1.2, whereas 64% of the drug was released in pH = 7.4. This is in contrary to pure alendronate that was completely dissolved within 30 min in the first release media (pH = 1.2) only. The relatively larger uptake of alendronate in this carbon and its sustained fashion of release can be attributed to the hydrogen bonding between the drug and the nitrogen functionalities on carbon surface. Based on this result, it can be inferred that this formulation may lower the side effects of oral delivery of alendronate.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1319229

Journal Information:: Microporous and Mesoporous Materials, Vol. 229, Issue C; ISSN 1387-1811

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 15 works

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36 MATERIALS SCIENCE
nitrogen doping
mesoporous carbon
alendronate
osteoporosis
controlled release

Title: Controlled release of alendronate from nitrogen-doped mesoporous carbon

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