Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same
Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula ##STR00001## where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.
- Research Organization:
- Univ. of Southern California, Los Angeles, CA (United States)
- Sponsoring Organization:
- USDOE
- Assignee:
- University of Southern California (Los Angeles, CA)
- Patent Number(s):
- 9,403,875
- Application Number:
- 12/695,125
- OSTI ID:
- 1281082
- Resource Relation:
- Patent File Date: 2010 Jan 27
- Country of Publication:
- United States
- Language:
- English
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