Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex
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January 2011 |
Unexpected Effects of FERM Domain Mutations on Catalytic Activity of Jak3
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November 2001 |
Janus Kinase (Jak) Subcellular Localization Revisited: THE EXCLUSIVE MEMBRANE LOCALIZATION OF ENDOGENOUS JANUS KINASE 1 BY CYTOKINE RECEPTOR INTERACTION UNCOVERS THE Jak·RECEPTOR COMPLEX TO BE EQUIVALENT TO A RECEPTOR TYROSINE KINASE
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May 2004 |
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
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September 2000 |
Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development
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November 1995 |
Dali server: conservation mapping in 3D
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May 2010 |
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
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June 2014 |
Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice
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November 2010 |
Structural basis of recognition of interferon-α receptor by tyrosine kinase 2
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April 2014 |
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
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September 1995 |
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes
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April 2008 |
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions
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November 2004 |
The JAK-STAT Pathway at Twenty
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April 2012 |
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
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August 2011 |
Jaks and cytokine receptors—An intimate relationship
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November 2006 |
Inference of Macromolecular Assemblies from Crystalline State
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September 2007 |
Modular Peptide Recognition Domains in Eukaryotic Signaling
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June 1997 |
Dual Role of the Jak1 FERM and Kinase Domains in Cytokine Receptor Binding and in Stimulation-Dependent Jak Activation
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January 2008 |
Phosphorylation Reaction in cAPK Protein Kinase-Free Energy Quantum Mechanical/Molecular Mechanics Simulations
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November 2007 |
Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2
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October 2006 |
JAK–cytokine receptor recognition, unboxed
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May 2014 |
Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability
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May 2005 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
Molecular Modeling of the Jak3 Kinase Domains and Structural Basis for Severe Combined Immunodeficiency
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August 2000 |
Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck
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March 1993 |
Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency
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October 2001 |
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids
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May 2010 |
Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain
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April 2000 |
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
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September 2013 |
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
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May 2014 |
Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain
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March 1999 |
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.
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December 1991 |
Phaser crystallographic software
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July 2007 |
Hematopoietic cytokine receptor signaling
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October 2007 |
Structural and Functional Basis for JAK3-Deficient Severe Combined Immunodeficiency
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November 1997 |
A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F)
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January 2010 |
Mapping of a Region within the N Terminus of Jak1 Involved in Cytokine Receptor Interaction
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July 2001 |
The Jak1 SH2 Domain Does Not Fulfill a Classical SH2 Function in Jak/STAT Signaling but Plays a Structural Role for Receptor Interaction and Up-regulation of Receptor Surface Expression
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May 2005 |
Genetics of Myeloproliferative Neoplasms
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January 2014 |
XDS
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January 2010 |
Features and development of Coot
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March 2010 |
Overview of the CCP 4 suite and current developments
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March 2011 |
Janus kinases in immune cell signaling
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March 2009 |
Jak3-Independent Trafficking of the Common γ Chain Receptor Subunit: Chaperone Function of Jaks Revisited
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June 2004 |
SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome
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January 2012 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution.
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