Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids

Jin, Haibao; Jiao, Fang; Daily, Michael D.; Chen, Yulin; Yan, Feng; Ding, Yan-Huai; Zhang, Xin; Robertson, Ellen J.; Baer, Marcel D.; Chen, Chun-Long

doi:10.1038/ncomms12252

Title: Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids

Journal Article · Tue Jul 12 00:00:00 EDT 2016 · Nature Communications

DOI:https://doi.org/10.1038/ncomms12252· OSTI ID:1267592

Jin, Haibao ^[1]; Jiao, Fang ^[2]; Daily, Michael D. ^[1]; Chen, Yulin ^[1]; Yan, Feng ^[3]; Ding, Yan-Huai ^[4]; Zhang, Xin ^[1]; Robertson, Ellen J. ^[5]; Baer, Marcel D. ^[1]; Chen, Chun-Long ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Division of Physical Sciences
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Division of Physical Sciences; East China Normal Univ. (ECNU), Shanghai (China). School of Chemistry and Molecular Engineering
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Division of Physical Sciences; Linyi Univ., Linyi (China). College of Chemistry and Chemical Engineering
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Division of Physical Sciences; Xiangtan Univ., Xiantan (China). Inst. of Rheology Mechanics
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry

An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. Here we report the assembly of lipid-like peptoids into highly stable, crystalline, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallization process. Both experimental and molecular dynamics simulation results show that peptoids assemble into membranes through an anisotropic formation process. We further demonstrated the use of peptoid membranes as a robust platform to incorporate and pattern functional objects through large side-chain diversity and/or co-crystallization approaches. Similar to lipid membranes, peptoid membranes exhibit changes in thickness upon exposure to external stimuli; they can coat surfaces in single layers and self-repair. We anticipate that this new class of membrane-mimetic 2D nanomaterials will provide a robust matrix for development of biomimetic membranes tailored to specific applications.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-76RL01830; AC02-05CH11231

OSTI ID:: 1267592

Alternate ID(s):: OSTI ID: 1439997

Report Number(s):: PNNL-SA-112006

Journal Information:: Nature Communications, Vol. 7; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 93 works

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