A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices

Zhang, Shiyi; Bellinger, Andrew M.; Glettig, Dean L.; Barman, Ross; Lee, Young-Ah Lucy; Zhu, Jiahua; Cleveland, Cody; Montgomery, Veronica A.; Gu, Li; Nash, Landon D.; Maitland, Duncan J.; Langer, Robert; Traverso, Giovanni

doi:10.1038/nmat4355

Title: A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices

Journal Article · Mon Jul 27 00:00:00 EDT 2015 · Nature Materials

DOI:https://doi.org/10.1038/nmat4355· OSTI ID:1265875

Zhang, Shiyi ^[1]; Bellinger, Andrew M. ^[2]; Glettig, Dean L. ^[1]; Barman, Ross ^[2]; Lee, Young-Ah Lucy ^[1]; Zhu, Jiahua ^[3]; Cleveland, Cody ^[1]; Montgomery, Veronica A. ^[1]; Gu, Li ^[1]; Nash, Landon D. ^[4]; Maitland, Duncan J. ^[4]; Langer, Robert ^[1]; Traverso, Giovanni ^[2]

Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Harvard Medical School, Boston, MA (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Texas A & M Univ., College Station, TX (United States)

Devices resident in the stomach used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric-retentive dosage forms for prolonged drug delivery typically incorporate elastic polymers to compress the devices during delivery through the oesophagus and other narrow orifices in the digestive system. In the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. We determine that these enteric elastomers should increase the safety profile for a wide range of gastricretentive devices.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1265875

Journal Information:: Nature Materials, Vol. 14, Issue 10; ISSN 1476-1122

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 238 works

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Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine Hoque, Jiaul; Sangaj, Nivedita; Varghese, Shyni Macromolecular Bioscience, Vol. 19, Issue 1 https://doi.org/10.1002/mabi.201800259	journal	October 2018
Engineering Strategies for Oral Therapeutic Enzymes to Enhance Their Stability and Activity Lapuhs, Philipp; Fuhrmann, Gregor Advances in Experimental Medicine and Biology https://doi.org/10.1007/978-981-13-7709-9_8	book	January 2019
Novel pH/reduction responsive graphene oxide nanoparticles based hydrogel for targeted combination chemotherapy Anirudhan, Thayyath Sreenivasan; Manasa, A. M. International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 70, Issue 4 https://doi.org/10.1080/00914037.2019.1706513	journal	December 2019
Designing Hydrogels for Controlled Drug Delivery Trombino, Sonia; Cassano, Roberta https://doi.org/10.3390/books978-3-03928-357-6	book	February 2020
Novel pH/reduction responsive graphene oxide nanoparticles based hydrogel for targeted combination chemotherapy Anirudhan, Thayyath Sreenivasan; Manasa, A. M. Taylor & Francis https://doi.org/10.6084/m9.figshare.11474316	text	January 2019
Supramolecular Interfacial Polymerization: A Controllable Method of Fabricating Supramolecular Polymeric Materials Qin, Bo; Zhang, Shuai; Song, Qiao Angewandte Chemie, Vol. 129, Issue 26 https://doi.org/10.1002/ange.201703572	journal	May 2017
Using zeta potential to study the ionisation behaviour of polymers employed in modified-release dosage forms and estimating their pKa Barbosa, Joao A. C.; Abdelsadig, Malaz S. E.; Conway, Barbara R. International Journal of Pharmaceutics: X, Vol. 1 https://doi.org/10.1016/j.ijpx.2019.100024	journal	December 2019

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