Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy

Punjabi, Amol; Wu, Xiang; Tokatli-Apollon, Amira; El-Rifai, Mahmoud; Lee, Hyungseok; Zhang, Yuanwei; Wang, Chao; Liu, Zhuang; Chan, Emory M.; Duan, Chunying; Han, Gang

doi:10.1021/nn505051d

Title: Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy

Journal Article · Thu Sep 25 00:00:00 EDT 2014 · ACS Nano

DOI:https://doi.org/10.1021/nn505051d· OSTI ID:1257361

Punjabi, Amol ^[1]; Wu, Xiang ^[2]; Tokatli-Apollon, Amira ^[1]; El-Rifai, Mahmoud ^[1]; Lee, Hyungseok ^[1]; Zhang, Yuanwei ^[1]; Wang, Chao ^[3]; Liu, Zhuang ^[3]; Chan, Emory M. ^[4]; Duan, Chunying ^[5]; Han, Gang ^[1]

Univ. of Massachusetts, Amherst, MA (United States)
Univ. of Massachusetts, Amherst, MA (United States); Dalian Univ. of Technology, Dalian (China)
Soochow Univ., Suzhou, Jiangsu (China)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Foundry
Dalian Univ. of Technology, Dalian (China)

A class of biocompatible upconverting nanoparticles (UCNPs) with largely amplified red-emissions was developed. The optimal UCNP shows a high absolute upconversion quantum yield of 3.2% in red-emission, which is 15-fold stronger than the known optimal β-phase core/shell UCNPs. When conjugated to aminolevulinic acid, a clinically used photodynamic therapy (PDT) prodrug, significant PDT effect in tumor was demonstrated in a deep-tissue (>1.2 cm) setting in vivo at a biocompatible laser power density. Furthermore, we show that our UCNP–PDT system with NIR irradiation outperforms clinically used red light irradiation in a deep tumor setting in vivo. This study marks a major step forward in photodynamic therapy utilizing UCNPs to effectively access deep-set tumors.Lastly, it also provides an opportunity for the wide application of upconverting red radiation in photonics and biophotonics.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231; R01MH103133; RGY0090/2014

OSTI ID:: 1257361

Journal Information:: ACS Nano, Vol. 8, Issue 10; ISSN 1936-0851

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 227 works

Citation information provided by
Web of Science

References (44)

Nanoparticles in photodynamic therapy: An emerging paradigm Chatterjee, Dev Kumar; Fong, Li Shan; Zhang, Yong Advanced Drug Delivery Reviews, Vol. 60, Issue 15 https://doi.org/10.1016/j.addr.2008.08.003	journal	December 2008
Photodynamic therapy for cancer Dolmans, Dennis E. J. G. J.; Fukumura, Dai; Jain, Rakesh K. Nature Reviews Cancer, Vol. 3, Issue 5 https://doi.org/10.1038/nrc1071	journal	May 2003
Activatable Photosensitizers for Imaging and Therapy Lovell, Jonathan F.; Liu, Tracy W. B.; Chen, Juan Chemical Reviews, Vol. 110, Issue 5 https://doi.org/10.1021/cr900236h	journal	May 2010
Basic principles of photodynamic therapy Macdonald, Ian J.; Dougherty, Thomas J. Journal of Porphyrins and Phthalocyanines, Vol. 05, Issue 02 https://doi.org/10.1002/jpp.328	journal	February 2001
Phase I clinical trial of the use of zinc phthalocyanine tetrasulfonate as a photosensitizer for photodynamic therapy in dogs Borgatti-Jeffreys, Antonella; Hooser, Stephen B.; Miller, Margaret A. American Journal of Veterinary Research, Vol. 68, Issue 4 https://doi.org/10.2460/ajvr.68.4.399	journal	April 2007
Photodynamic Therapy Dougherty, T. J.; Gomer, C. J.; Henderson, B. W. JNCI Journal of the National Cancer Institute, Vol. 90, Issue 12 https://doi.org/10.1093/jnci/90.12.889	journal	June 1998
A Review of Progress in Clinical Photodynamic Therapy Huang, Zheng Technology in Cancer Research & Treatment, Vol. 4, Issue 3 https://doi.org/10.1177/153303460500400308	journal	June 2005
5-Aminolevulinic Acid-Based Photodynamic Therapy: Principles and Experimental Research Peng, Qian; Berg, Kristian; Moan, Johan Photochemistry and Photobiology, Vol. 65, Issue 2 https://doi.org/10.1111/j.1751-1097.1997.tb08549.x	journal	February 1997
5-Aminolevulinic acid-based photodynamic therapy: Clinical research and future challenges Peng, Qian; Warloe, Trond; Berg, Kristian Cancer, Vol. 79, Issue 12 https://doi.org/10.1002/(SICI)1097-0142(19970615)79:12<2282::AID-CNCR2>3.0.CO;2-O	journal	June 1997
Review of photodynamic therapy in actinic keratosis and basal cell carcinoma Larko, Olle Therapeutics and Clinical Risk Management, Vol. Volume 4 https://doi.org/10.2147/TCRM.S1769	journal	January 2008
Photosensitization of Singlet Oxygen via Two-Photon-Excited Fluorescence Resonance Energy Transfer in a Water-Soluble Dendrimer Oar, Michael A.; Serin, Jason M.; Dichtel, William R. Chemistry of Materials, Vol. 17, Issue 9 https://doi.org/10.1021/cm047825i	journal	April 2005
Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy Wang, Shizhong; Gao, Ruomei; Zhou, Feimeng Journal of Materials Chemistry, Vol. 14, Issue 4 https://doi.org/10.1039/b311429e	journal	January 2004
Upconverting Nanoparticles Haase, Markus; Schäfer, Helmut Angewandte Chemie International Edition, Vol. 50, Issue 26 https://doi.org/10.1002/anie.201005159	journal	May 2011
Upconversion-Nanophosphor-Based Functional Nanocomposites Feng, Wei; Han, Chunmiao; Li, Fuyou Advanced Materials, Vol. 25, Issue 37 https://doi.org/10.1002/adma.201301946	journal	August 2013
Upconversion nanoparticles in biological labeling, imaging, and therapy Wang, Feng; Banerjee, Debapriya; Liu, Yongsheng The Analyst, Vol. 135, Issue 8 https://doi.org/10.1039/c0an00144a	journal	January 2010
Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals Wang, Feng; Liu, Xiaogang Chemical Society Reviews, Vol. 38, Issue 4 https://doi.org/10.1039/b809132n	journal	January 2009
Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles Wang, Chao; Tao, Huiquan; Cheng, Liang Biomaterials, Vol. 32, Issue 26 https://doi.org/10.1016/j.biomaterials.2011.05.007	journal	September 2011
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers Idris, Niagara Muhammad; Gnanasammandhan, Muthu Kumara; Zhang, Jing Nature Medicine, Vol. 18, Issue 10 https://doi.org/10.1038/nm.2933	journal	September 2012
Upconverting nanoparticles as nanotransducers for photodynamic therapy in cancer cells Chatterjee, Dev K.; Yong, Zhang Nanomedicine, Vol. 3, Issue 1 https://doi.org/10.2217/17435889.3.1.73	journal	February 2008
Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells Liu, Kai; Liu, Xiaomin; Zeng, Qinghui ACS Nano, Vol. 6, Issue 5 https://doi.org/10.1021/nn300436b	journal	April 2012
Pegylated Composite Nanoparticles Containing Upconverting Phosphors and meso-Tetraphenyl porphine (TPP) for Photodynamic Therapy Shan, Jingning; Budijono, Stephanie J.; Hu, Guohong Advanced Functional Materials, Vol. 21, Issue 13 https://doi.org/10.1002/adfm.201002516	journal	May 2011
Mesoporous-Silica-Coated Up-Conversion Fluorescent Nanoparticles for Photodynamic Therapy Qian, Hai Sheng; Guo, Hui Chen; Ho, Paul Chi-Lui Small, Vol. 5, Issue 20 https://doi.org/10.1002/smll.200900692	journal	October 2009
Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy Wang, Chao; Cheng, Liang; Liu, Zhuang Biomaterials, Vol. 32, Issue 4 https://doi.org/10.1016/j.biomaterials.2010.09.069	journal	February 2011
Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation Tian, Gan; Ren, Wenlu; Yan, Liang Small, Vol. 9, Issue 11 https://doi.org/10.1002/smll.201201437	journal	December 2012
Mn2+ Dopant-Controlled Synthesis of NaYF4:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery Tian, Gan; Gu, Zhanjun; Zhou, Liangjun Advanced Materials, Vol. 24, Issue 9 https://doi.org/10.1002/adma.201104741	journal	January 2012
Lanthanide-Doped Na _x ScF _{3+ x} Nanocrystals: Crystal Structure Evolution and Multicolor Tuning Teng, Xue; Zhu, Yihan; Wei, Wei Journal of the American Chemical Society, Vol. 134, Issue 20 https://doi.org/10.1021/ja3016236	journal	May 2012
Orthorhombic KSc2F7:Yb/Er nanorods: controlled synthesis and strong red upconversion emission Ding, Yujie; Teng, Xue; Zhu, Hao Nanoscale, Vol. 5, Issue 23 https://doi.org/10.1039/c3nr01840g	journal	January 2013
Absolute quantum yield measurements of colloidal NaYF4: Er3+, Yb3+ upconverting nanoparticles Boyer, John-Christopher; van Veggel, Frank C. J. M. Nanoscale, Vol. 2, Issue 8 https://doi.org/10.1039/c0nr00253d	journal	January 2010
Hexagonal Sodium Yttrium Fluoride Based Green and Blue Emitting Upconversion Phosphors Krämer, Karl W.; Biner, Daniel; Frei, Gabriela Chemistry of Materials, Vol. 16, Issue 7 https://doi.org/10.1021/cm031124o	journal	April 2004
Rare-Earth Nanoparticles with Enhanced Upconversion Emission and Suppressed Rare-Earth-Ion Leakage Wang, Ye-Fu; Sun, Ling-Dong; Xiao, Jia-Wen Chemistry - A European Journal, Vol. 18, Issue 18 https://doi.org/10.1002/chem.201103485	journal	April 2012
(α-NaYbF ₄ :Tm ³⁺ )/CaF ₂ Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging Chen, Guanying; Shen, Jie; Ohulchanskyy, Tymish Y. ACS Nano, Vol. 6, Issue 9 https://doi.org/10.1021/nn302972r	journal	August 2012
Triple-functional core–shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro Qiao, Xiao-Fei; Zhou, Jia-Cai; Xiao, Jia-Wen Nanoscale, Vol. 4, Issue 15 https://doi.org/10.1039/c2nr30938f	journal	January 2012
Upconversion: Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α-NaYF ₄ :Yb,Tm)/CaF ₂ Core/Shell Nanoparticles for In situ Real-time Recorded Biocompatible Photoactivation (Small 19/2013) Shen, Jie; Chen, Guanying; Ohulchanskyy, Tymish Y. Small, Vol. 9, Issue 19 https://doi.org/10.1002/smll.201370117	journal	October 2013
Tuning upconversion through energy migration in core–shell nanoparticles Wang, Feng; Deng, Renren; Wang, Juan Nature Materials, Vol. 10, Issue 12 https://doi.org/10.1038/nmat3149	journal	October 2011
Upconversion Multicolor Fine-Tuning: Visible to Near-Infrared Emission from Lanthanide-Doped NaYF ₄ Nanoparticles Wang, Feng; Liu, Xiaogang Journal of the American Chemical Society, Vol. 130, Issue 17 https://doi.org/10.1021/ja800868a	journal	April 2008
Enhancing multiphoton upconversion through energy clustering at sublattice level Wang, Juan; Deng, Renren; MacDonald, Mark A. Nature Materials, Vol. 13, Issue 2 https://doi.org/10.1038/nmat3804	journal	November 2013
Upconverting Near-Infrared Light through Energy Management in Core-Shell-Shell Nanoparticles Wen, Hongli; Zhu, Hai; Chen, Xian Angewandte Chemie International Edition, Vol. 52, Issue 50 https://doi.org/10.1002/anie.201306811	journal	October 2013
Doxorubicin conjugated NaYF4:Yb3+/Tm3+ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer Dai, Yunlu; Yang, Dongmei; Ma, Ping'an Biomaterials, Vol. 33, Issue 33 https://doi.org/10.1016/j.biomaterials.2012.08.029	journal	November 2012
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics Chen, Guanying; Qiu, Hailong; Prasad, Paras N. Chemical Reviews, Vol. 114, Issue 10 https://doi.org/10.1021/cr400425h	journal	March 2014
Stem Cell Labeling using Polyethylenimine Conjugated (α-NaYbF ₄ :Tm ³⁺ )/CaF ₂ Upconversion Nanoparticles Zhao, Liang; Kutikov, Artem; Shen, Jie Theranostics, Vol. 3, Issue 4 https://doi.org/10.7150/thno.5432	journal	January 2013
Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α-NaYF ₄ :Yb,Tm)/CaF ₂ Core/Shell Nanoparticles for In situ Real-time Recorded Biocompatible Photoactivation Shen, Jie; Chen, Guanying; Ohulchanskyy, Tymish Y. Small https://doi.org/10.1002/smll.201300234	journal	May 2013
Phase II clinical study of photodynamic therapy using mono-l-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung Kato, Harubumi; Furukawa, Kinya; Sato, Masami Lung Cancer, Vol. 42, Issue 1 https://doi.org/10.1016/s0169-5002(03)00242-3	journal	October 2003
Photosensitized oxidation of 2′,7′-dichlorofluorescin: singlet oxygen does not contribute to the formation of fluorescent oxidation product 2′,7′-dichlorofluorescein Bilski, P.; Belanger, A. G.; Chignell, C. F. Free Radical Biology and Medicine, Vol. 33, Issue 7 https://doi.org/10.1016/s0891-5849(02)00982-6	journal	October 2002
On the Selectivity of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Formation Collaud, Sabine; Juzeniene, Asta; Moan, Johan Current Medicinal Chemistry-Anti-Cancer Agents, Vol. 4, Issue 3 https://doi.org/10.2174/1568011043352984	journal	May 2004

Cited By (60)

An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy Ai, Fujin; Wang, Na; Zhang, Xiaoman Nanoscale, Vol. 10, Issue 9 https://doi.org/10.1039/c7nr06874c	journal	January 2018
Recent progress in upconversion luminescence nanomaterials for biomedical applications Duan, Chengchen; Liang, Liuen; Li, Li Journal of Materials Chemistry B, Vol. 6, Issue 2 https://doi.org/10.1039/c7tb02527k	journal	January 2018
Overcoming the Achilles' heel of photodynamic therapy Fan, Wenpei; Huang, Peng; Chen, Xiaoyuan Chemical Society Reviews, Vol. 45, Issue 23 https://doi.org/10.1039/c6cs00616g	journal	January 2016
Facile preparation of versatile gadolinium-chelated protein nanocomposite for T ₁ magnetic resonance imaging-guided photodynamic and photothermal synergetic therapy Liu, Pei; Zheng, Hongyi; Yang, Zhe Journal of Materials Chemistry B, Vol. 6, Issue 11 https://doi.org/10.1039/c8tb00148k	journal	January 2018
Dopant-dependent crystallization and photothermal effect of Sb-doped SnO ₂ nanoparticles as stable theranostic nanoagents for tumor ablation Yu, Nuo; Peng, Chen; Wang, Zhaojie Nanoscale, Vol. 10, Issue 5 https://doi.org/10.1039/c7nr08811f	journal	January 2018
Upconversion in Nanostructured Materials: From Optical Tuning to Biomedical Applications Sun, Tianying; Ai, Fujin; Zhu, Guangyu Chemistry - An Asian Journal, Vol. 13, Issue 4 https://doi.org/10.1002/asia.201701660	journal	January 2018
Manipulating energy transfer in lanthanide-doped single nanoparticles for highly enhanced upconverting luminescence Zhuo, Zhu; Liu, Yongsheng; Liu, Dajiu Chemical Science, Vol. 8, Issue 7 https://doi.org/10.1039/c7sc01393k	journal	January 2017
Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers Zhao, Jie; Duan, Li; Wang, Anhe WIREs Nanomedicine and Nanobiotechnology, Vol. 12, Issue 1 https://doi.org/10.1002/wnan.1583	journal	September 2019
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy Zhou, Zijian; Song, Jibin; Nie, Liming Chemical Society Reviews, Vol. 45, Issue 23 https://doi.org/10.1039/c6cs00271d	journal	January 2016
Upconverting NIR Photons for Bioimaging Li, Zhanjun; Zhang, Yuanwei; La, Hieu Nanomaterials, Vol. 5, Issue 4 https://doi.org/10.3390/nano5042148	journal	December 2015
Carbon-Dot-Decorated TiO ₂ Nanotubes toward Photodynamic Therapy Based on Water-Splitting Mechanism Yang, Dan; Yang, Guixin; Sun, Qianqian Advanced Healthcare Materials, Vol. 7, Issue 10 https://doi.org/10.1002/adhm.201800042	journal	March 2018
Glutathione Activatable Photosensitizer-Conjugated Pseudopolyrotaxane Nanocarriers for Photodynamic Theranostics Tong, Hongxin; Chen, Yangjun; Li, Zuhong Small, Vol. 12, Issue 45 https://doi.org/10.1002/smll.201601966	journal	September 2016
Revisiting the optimized doping ratio in core/shell nanostructured upconversion particles Shen, Bin; Cheng, Shengming; Gu, Yuyang Nanoscale, Vol. 9, Issue 5 https://doi.org/10.1039/c6nr07687d	journal	January 2017
Blue Te Nanoneedles with Strong NIR Photothermal and Laser-Enhanced Anticancer Effects as “All-in-One” Nanoagents for Synergistic Thermo-Chemotherapy of Tumors Yu, Nuo; Li, Jinning; Wang, Zhaojie Advanced Healthcare Materials, Vol. 7, Issue 21 https://doi.org/10.1002/adhm.201800643	journal	August 2018
A “win–win” nanoplatform: TiO ₂ :Yb,Ho,F for NIR light-induced synergistic therapy and imaging Zhou, Jie; Luo, Pei; Sun, Chong Nanoscale, Vol. 9, Issue 12 https://doi.org/10.1039/c6nr09717k	journal	January 2017
Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy Wang, Shunhao; Shang, Lu; Li, Linlin Advanced Materials, Vol. 28, Issue 38 https://doi.org/10.1002/adma.201602197	journal	July 2016
Advances in highly doped upconversion nanoparticles Wen, Shihui; Zhou, Jiajia; Zheng, Kezhi Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04813-5	journal	June 2018
Low power density 980 nm-driven ultrabright red-emitting upconversion nanoparticles via synergetic Yb ³⁺ /Tm ³⁺ cascade-sensitization Liu, Jiao; Wu, Shihong; Chu, Huiyuan Journal of Materials Chemistry C, Vol. 7, Issue 43 https://doi.org/10.1039/c9tc04174e	journal	January 2019
Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms Chi, Minghan; Qi, Manlin; A., Lan International Journal of Molecular Sciences, Vol. 20, Issue 2 https://doi.org/10.3390/ijms20020278	journal	January 2019
Luminescent Rare-earth-based Nanoparticles: A Summarized Overview of their Synthesis, Functionalization, and Applications Escudero, Alberto; Carrillo-Carrión, Carolina; Zyuzin, Mikhail V. Topics in Current Chemistry, Vol. 374, Issue 4 https://doi.org/10.1007/s41061-016-0049-8	journal	July 2016
Dynamically tuning near-infrared-induced photothermal performances of TiO ₂ nanocrystals by Nb doping for imaging-guided photothermal therapy of tumors Yu, Nuo; Hu, Yong; Wang, Xiaoyong Nanoscale, Vol. 9, Issue 26 https://doi.org/10.1039/c7nr02180a	journal	January 2017
Prospects For Application of Upconversion Particles NaYF4:Er,Yb for Phototherapy [ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ АПКОНВЕРСИОННЫХ ЧАСТИЦ NaYF4:Er,Yb ДЛЯ ФОТОТЕРАПИИ] Kochubey, V. I.; Sagaidachnaya, Е. А.; Yanina, I. Yu. Izvestiya of Saratov University. New Series. Series: Physics, Vol. 18, Issue 4 https://doi.org/10.18500/1817-3020-2018-18-4-253-274	journal	January 2018
Interconversion between KSc ₂ F ₇ :Yb/Er and K ₂ NaScF ₆ :Yb/Er nanocrystals: the role of chemistry Wang, Yangbo; Yang, Bingxiao; Chen, Kun Dalton Transactions, Vol. 47, Issue 14 https://doi.org/10.1039/c7dt04658h	journal	January 2018
BiVO ₄ as highly efficient host for near-infrared to visible upconversion Regmi, Chhabilal; Kshetri, Yuwaraj K.; Jeong, Sang Hoon Journal of Applied Physics, Vol. 125, Issue 4 https://doi.org/10.1063/1.5064726	journal	January 2019
Facile Phototherapeutic Nanoplatform by Integrating a Multifunctional Polymer and MnO ₂ for Enhancing Tumor Synergistic Therapy Zhao, Menglong; Xie, Mingjuan; Guo, Jungu Advanced Healthcare Materials, Vol. 8, Issue 15 https://doi.org/10.1002/adhm.201900414	journal	June 2019
Confining energy migration in upconversion nanoparticles towards deep ultraviolet lasing Chen, Xian; Jin, Limin; Kong, Wei Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms10304	journal	January 2016
Lanthanide upconversion luminescence at the nanoscale: fundamentals and optical properties Nadort, Annemarie; Zhao, Jiangbo; Goldys, Ewa M. Nanoscale, Vol. 8, Issue 27 https://doi.org/10.1039/c5nr08477f	journal	January 2016
Recent Advancements in Ln‐Ion‐Based Upconverting Nanomaterials and Their Biological Applications Chhetri, Bijay P.; Karmakar, Alokita; Ghosh, Anindya Particle & Particle Systems Characterization, Vol. 36, Issue 8 https://doi.org/10.1002/ppsc.201900153	journal	July 2019
Effect of Tm3+ Concentration on the Generation of Reactive Oxygen Species in NaYb1 – xF4${\text{Tm}}_{x}^{{3 + }}$$ for the Multifunctional Photosensitizer Zhang, J. Y.; Wang, Q. Y.; Liang, H. Russian Journal of Physical Chemistry A, Vol. 93, Issue 13 https://doi.org/10.1134/s0036024419130387	journal	December 2019
Au Nanoclusters Sensitized Black TiO ₂₋ _x Nanotubes for Enhanced Photodynamic Therapy Driven by Near-Infrared Light Yang, Dan; Gulzar, Arif; Yang, Guixin Small, Vol. 13, Issue 48 https://doi.org/10.1002/smll.201703007	journal	November 2017
Responsive Assembly of Upconversion Nanoparticles for pH‐Activated and Near‐Infrared‐Triggered Photodynamic Therapy of Deep Tumors Li, Fangyuan; Du, Yang; Liu, Jianan Advanced Materials, Vol. 30, Issue 35 https://doi.org/10.1002/adma.201802808	journal	July 2018
Nanocarriers and Their Loading Strategies Wang, Neng; Cheng, Xuejun; Li, Nan Advanced Healthcare Materials, Vol. 8, Issue 6 https://doi.org/10.1002/adhm.201801002	journal	November 2018
NIR/blue light emission optimization of NaY _1−(x+y) Yb _x F ₄ :Tm _y upconversion nanoparticles via Yb ³⁺ /Tm ³⁺ dopant balancing Bagheri, Ali; Li, Zheye; Boyer, Cyrille Dalton Transactions, Vol. 47, Issue 26 https://doi.org/10.1039/c7dt04768a	journal	January 2018
Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles Wang, Bing-Yen; Liao, Ming-Liang; Hong, Guan-Ci Nanomaterials, Vol. 7, Issue 9 https://doi.org/10.3390/nano7090269	journal	September 2017
Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery Han, Sanyang; Samanta, Animesh; Xie, Xiaoji Advanced Materials, Vol. 29, Issue 18 https://doi.org/10.1002/adma.201700244	journal	March 2017
Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma Camerin, Monica; Moreno, Miguel; Marín, María J. Photochemical & Photobiological Sciences, Vol. 15, Issue 5 https://doi.org/10.1039/c5pp00463b	journal	January 2016
A Nd ³⁺ sensitized upconversion nanosystem with dual photosensitizers for improving photodynamic therapy efficacy Yang, Man; Wang, Han; Wang, Zhaohui Biomaterials Science, Vol. 7, Issue 4 https://doi.org/10.1039/c8bm01570h	journal	January 2019
Fine-tuning of multiple upconversion emissions by controlling the crystal phase and morphology between GdF ₃ :Yb ³⁺ ,Tm ³⁺ and GdOF:Yb ³⁺ ,Tm ³⁺ nanocrystals Zhu, Yongsheng; Bi, Dongqin; Wang, Huiqiao RSC Advances, Vol. 7, Issue 5 https://doi.org/10.1039/c6ra27024g	journal	January 2017
Enhanced red up-conversion luminescence in La4−x−yGd10Ge2B6O34:Ybx,Ery synthesized by the liquid-phase homogenization with tartaric acid Krut’ko, V. A.; Komova, M. G.; Pominova, D. V. Journal of Sol-Gel Science and Technology, Vol. 92, Issue 2 https://doi.org/10.1007/s10971-019-05082-4	journal	July 2019
Confining Excitation Energy in Er ³⁺ -Sensitized Upconversion Nanocrystals through Tm ³⁺ -Mediated Transient Energy Trapping Chen, Qiushui; Xie, Xiaoji; Huang, Bolong Angewandte Chemie, Vol. 129, Issue 26 https://doi.org/10.1002/ange.201703012	journal	May 2017
One pot synthesis and systematic study of the photophysical and magnetic properties and thermal sensing of α and β-phase NaLnF ₄ and β-phase core@shell nanoparticles Rodrigues, E. M.; Gálico, D. A.; Lemes, M. A. New Journal of Chemistry, Vol. 42, Issue 16 https://doi.org/10.1039/c8nj02471e	journal	January 2018
Anti-Stokes shift luminescent materials for bio-applications Zhu, Xingjun; Su, Qianqian; Feng, Wei Chemical Society Reviews, Vol. 46, Issue 4 https://doi.org/10.1039/c6cs00415f	journal	January 2017
Direct optical lithography of functional inorganic nanomaterials Wang, Yuanyuan; Fedin, Igor; Zhang, Hao Science, Vol. 357, Issue 6349 https://doi.org/10.1126/science.aan2958	journal	July 2017
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics Tang, Wei; Fan, Wenpei; Lau, Joseph Chemical Society Reviews, Vol. 48, Issue 11 https://doi.org/10.1039/c8cs00805a	journal	January 2019
Halogenated Aza-BODIPY for Imaging-Guided Synergistic Photodynamic and Photothermal Tumor Therapy Zhao, Menglong; Xu, Yunjian; Xie, Mingjuan Advanced Healthcare Materials, Vol. 7, Issue 18 https://doi.org/10.1002/adhm.201800606	journal	July 2018
Ultrasmall Biocompatible WO ₃₋ _x Nanodots for Multi-Modality Imaging and Combined Therapy of Cancers Wen, Ling; Chen, Ling; Zheng, Shimin Advanced Materials, Vol. 28, Issue 25 https://doi.org/10.1002/adma.201506428	journal	May 2016
Near-Infrared-Triggered Azobenzene-Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance Yao, Chi; Wang, Peiyuan; Li, Xiaomin Advanced Materials, Vol. 28, Issue 42 https://doi.org/10.1002/adma.201503799	journal	August 2016
NaYbF ₄ @CaF ₂ core–satellite upconversion nanoparticles: one-pot synthesis and sensitive detection of glutathione Chen, Bing; Wang, Feng Nanoscale, Vol. 10, Issue 42 https://doi.org/10.1039/c8nr05552a	journal	January 2018
Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors Wang, Zhenzhen; Zhang, Yan; Ju, Enguo Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-05798-x	journal	August 2018
Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles Huang, Ling; Li, Zhanjun; Zhao, Yang Advanced Materials, Vol. 29, Issue 28 https://doi.org/10.1002/adma.201604789	journal	June 2017
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation He, Lian; Zhang, Yuanwei; Ma, Guolin eLife, Vol. 4 https://doi.org/10.7554/elife.10024	journal	December 2015
Recent advances in the synthesis and application of Yb-based fluoride upconversion nanoparticles Chen, Bing; Wang, Feng Inorganic Chemistry Frontiers, Vol. 7, Issue 5 https://doi.org/10.1039/c9qi01358j	journal	January 2020
Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization Fan, Wenpei; Shen, Bo; Bu, Wenbo Chemical Science, Vol. 6, Issue 3 https://doi.org/10.1039/c4sc03080j	journal	January 2015
Confining Excitation Energy in Er ³⁺ -Sensitized Upconversion Nanocrystals through Tm ³⁺ -Mediated Transient Energy Trapping Chen, Qiushui; Xie, Xiaoji; Huang, Bolong Angewandte Chemie International Edition, Vol. 56, Issue 26 https://doi.org/10.1002/anie.201703012	journal	May 2017
Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery Han, Sanyang; Samanta, Animesh; Xie, Xiaoji Advanced Materials, Vol. 29, Issue 40 https://doi.org/10.1002/adma.201704811	journal	October 2017
Plasmonic Nanoparticle-based Hybrid Photosensitizers with Broadened Excitation Profile for Photodynamic Therapy of Cancer Cells Wang, Peng; Tang, Hong; Zhang, Peng Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep34981	journal	October 2016
Strong Light-Field Driven Nanolasers Hollinger, Richard; Malevich, Pavel; Shumakova, Valentina GSI Helmholtzzentrum fuer Schwerionenforschung, GSI, Darmstadt https://doi.org/10.15120/gsi-2019-00859	text	January 2019
Core-Shell Nanostars for Multimodal Therapy and Imaging Li, Mengyuan; Li, Lele; Zhan, Changyou Theranostics, Vol. 6, Issue 13 https://doi.org/10.7150/thno.15843	journal	January 2016
Nanoscale “fluorescent stone”: Luminescent Calcium Fluoride Nanoparticles as Theranostic Platforms Li, Zhanjun; Zhang, Yuanwei; Huang, Ling Theranostics, Vol. 6, Issue 13 https://doi.org/10.7150/thno.15914	journal	January 2016
O₂-generating MnO₂ nanoparticles for enhanced photodynamic therapy of bladder cancer by ameliorating hypoxia Lin, Tingsheng; Zhao, Xiaozhi; Zhao, Sheng Theranostics, Vol. 8, Issue 4 https://doi.org/10.7150/thno.22465	journal	January 2018

Similar Records

Optically Robust and Biocompatible Mechanosensitive Upconverting Nanoparticles

Journal Article · Tue Jul 09 00:00:00 EDT 2019 · ACS Central Science · OSTI ID:1257361

Lay, Alice; Sheppard, Olivia H.; Siefe, Chris; +5 more

Bright Infrared‐to‐Ultraviolet/Visible Upconversion in Small Alkaline Earth‐Based Nanoparticles with Biocompatible CaF ₂ Shells

Journal Article · Wed Sep 23 00:00:00 EDT 2020 · Angewandte Chemie · OSTI ID:1257361

Fischer, Stefan; Siefe, Chris; Swearer, Dayne F.; +3 more

Bright Infrared‐to‐Ultraviolet/Visible Upconversion in Small Alkaline Earth‐Based Nanoparticles with Biocompatible CaF ₂ Shells

Journal Article · Wed Sep 23 00:00:00 EDT 2020 · Angewandte Chemie (International Edition) · OSTI ID:1257361

Fischer, Stefan; Siefe, Chris; Swearer, Dayne F.; +3 more

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
upconverting
nanoparticles
red-emission
prodrug
photodynamic therapy

Title: Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy

Citation Formats

References (44)

Cited By (60)

Similar Records

Related Subjects