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Title: Hybrid polyketide synthases

Patent ·
OSTI ID:1252447
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The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
9,334,514
Application Number:
13/882,099
OSTI ID:
1252447
Resource Relation:
Patent File Date: 2011 Oct 31
Country of Publication:
United States
Language:
English

References (18)

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NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases journal July 2004
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway journal June 2000
Mining microbial genomes for new natural products and biosynthetic pathways journal June 2008
Novel avermectins produced by mutational biosynthesis. journal January 1991
Biosynthesis of Nonribosomal Peptides journal October 2004
Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity journal April 2002
Tolerance and Specificity of Polyketide Synthases journal June 1999
Automated genome mining for natural products journal January 2009
Engineering Broader Specificity into an Antibiotic-Producing Polyketide Synthase journal January 1998
Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases journal September 2002
Stereochemical Determination and Complex Biosynthetic Assembly of Etnangien, a Highly Potent RNA Polymerase Inhibitor from the Myxobacterium Sorangium cellulosum journal October 2008
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338 journal March 2007
Unusual Chemistry in the Biosynthesis of the Antibiotic Chondrochlorens journal January 2009
Alteration of the Substrate Specificity of a Modular Polyketide Synthase Acyltransferase Domain through Site-Specific Mutations † journal December 2001
Polyketide synthesis in vitro on a modular polyketide synthase journal September 1995
Producing dicarboxylic acids using polyketide synthases patent October 2013
Host Cells and Methods for Producing Diacid Compounds patent-application October 2013

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