Monodisperse microdroplet generation and stopping without coalescence
A system for monodispersed microdroplet generation and trapping including providing a flow channel in a microchip; producing microdroplets in the flow channel, the microdroplets movable in the flow channel; providing carrier fluid in the flow channel using a pump or pressure source; controlling movement of the microdroplets in the flow channel and trapping the microdroplets in a desired location in the flow channel. The system includes a microchip; a flow channel in the microchip; a droplet maker that generates microdroplets, the droplet maker connected to the flow channel; a carrier fluid in the flow channel, the carrier fluid introduced to the flow channel by a source of carrier fluid, the source of carrier fluid including a pump or pressure source; a valve connected to the carrier fluid that controls flow of the carrier fluid and enables trapping of the microdroplets.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC52-07NA27344
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Number(s):
- 9,266,107
- Application Number:
- 14/662,535
- OSTI ID:
- 1239825
- Resource Relation:
- Patent File Date: 2015 Mar 19
- Country of Publication:
- United States
- Language:
- English
Monodisperse droplet generation and rapid trapping for single molecule detection and reaction kinetics measurement
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journal | January 2009 |
Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
|
patent-application | July 2008 |
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