Polymer scaffold degradation control via chemical control
A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.
- Research Organization:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC04-94AL85000
- Assignee:
- STC.UNM (Albuquerque, NM)
- Patent Number(s):
- 9,228,042
- Application Number:
- 14/147,983
- OSTI ID:
- 1234693
- Resource Relation:
- Patent File Date: 2014 Jan 06
- Country of Publication:
- United States
- Language:
- English
N.m.r. study of maleate (cis)—fumarate (trans) isomerism in unsaturated polyesters and related compounds
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journal | January 1995 |
Investigation of Maleate-Fumarate Isomerization in Unsaturated Polyesters by Nuclear Magnetic Resonance
|
journal | September 1964 |
Non cross-linked block polyetherester, preparation and uses
|
patent | December 2003 |
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