Microscopy imaging device with advanced imaging properties

Ghosh, Kunal; Burns, Laurie; El Gamal, Abbas; Schnitzer, Mark J.; Cocker, Eric; Ho, Tatt Wei

Title: Microscopy imaging device with advanced imaging properties

Patent · Tue Nov 24 00:00:00 EST 2015

OSTI ID:1227874

Ghosh, Kunal; Burns, Laurie; El Gamal, Abbas; Schnitzer, Mark J.; Cocker, Eric; Ho, Tatt Wei

Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 .mu.m resolution for an image of the field of view.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: The Board of Trustees of the Leland Stanford Junior University

Patent Number(s):: 9,195,043

Application Number:: 13/218,181

OSTI ID:: 1227874

Resource Relation:: Patent File Date: 2011 Aug 25

Country of Publication:: United States

Language:: English

References (104)

In vivo video camera system Iddan, Gavriel J.; Sturlesi, Doron https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5604531 US Patent Document 5,604,531	patent	February 1997
Apparatus for monitoring substances in organisms Goix, Philippe J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5798222 US Patent Document 5,798,222	patent	August 1998
Miniature scanning confocal microscope Dickensheets, David; Kino, Gordon S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6088145 US Patent Document 6,088,145	patent	July 2000
Miniature microscope Heacock, Gregory Lee; Watters, Wayde; Robinson, Joel https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6101028 US Patent Document 6,101,028	patent	August 2000
Semiconductor based excitation illuminator for fluorescence and phosphorescence microscopy Lilge, Lothar; Pennefather, Peter; Ross, Stanton E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6154282 US Patent Document 6,154,282	patent	November 2000
Portable tissue spectroscopy apparatus and method Crowley, Robert J.; Hamm, Mark A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6324418 US Patent Document 6,324,418	patent	November 2001
Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics Edman, Carl; Tu, Eugene; Gurtner, Christian https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6780584 US Patent Document 6,780,584	patent	August 2004
Capsule endoscope Yokoi, Takeshi; Hasegawa, Akira; Matsumoto, Shinya https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6855111 US Patent Document 6,855,111	patent	February 2005
Imaging system with an integrated source and detector array Olszak, Artur; Liang, Chen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6987259 US Patent Document 6,987,259	patent	January 2006
Miniature microscope objective lens Liang, Chen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7023622 US Patent Document 7,023,622	patent	April 2006
Miniaturized microscope array digital slide scanner Weinstein, Ronald S.; Descour, Michael R.; Liang, Chen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7184610 US Patent Document 7,184,610	patent	February 2007
EPI-illumination system for an array microscope Olszak, Artur; Liang, Chen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7193775 US Patent Document 7,193,775	patent	March 2007
Method and apparatus for high resolution coherent optical imaging Yang, Victor Xiao Dong; Vitkin, I. Alex; WongKeeSong, Louis M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7242833 US Patent Document 7,242,833	patent	July 2007
Fluorescence correlation spectroscopy instrument and method of using the same Wolf, David E.; Bulseco, Dylan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7268878 US Patent Document 7,268,878	patent	September 2007
Laser crystallization apparatus and laser crystallization method Takami, Yoshio https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7292320 US Patent Document 7,292,320	patent	November 2007
Micro-optical analysis system and approach therefor Schnitzer, Mark J.; Anderson, Erik Paul; Cocker, Eric https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7307774 US Patent Document 7,307,774	patent	December 2007
Capsule endoscope and a capsule endoscope system Kimoto, Seiichiro; Fujimori, Noriyuki; Suzushima, Hiroshi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7316647 US Patent Document 7,316,647	patent	January 2008
Compact fluorescence endoscopy video system Cline, Richard W.; Fengler, John; Boehm, Joachim W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7341557 US Patent Document 7,341,557	patent	March 2008
Wireless in-vivo information acquiring system and body-insertable device Shimizu, Hatsuo; Nakatsuchi, Kazutaka https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7419468 US Patent Document 7,419,468	patent	September 2008
Light scanning microscope and use Funk, Joerg-Michael; Wolleschensky, Ralf; Steinert, Joerg https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7561326 US Patent Document 7,561,326	patent	July 2009
Optical delivery systems and methods of providing adjustable beam diameter, spot size and/or spot shape Andersen, Dan; Angeley, David; Gooding, Philip https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7599591 US Patent Document 7,599,591	patent	October 2009
Active CMOS biosensor chip for fluorescent-based detection Shepard, Kenneth L.; Levicky, Rastislav; Patounakis, George https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7738086 US Patent Document 7,738,086	patent	June 2010
Ingestible device platform for the colon Zilberstein, Yoel; Nagler, Michael; Rousso, Benny https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7970455 US Patent Document 7,970,455	patent	June 2011
Ingestible pill for diagnosing a gastrointestinal tract Kimchy, Yoav; Amrami, Roni; Bouskila, Yona https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8036731 US Patent Document 8,036,731	patent	October 2011
Device and method for wide-field and high resolution imaging of tissue Yaroslavsky, Anna M.; Webb, Robert H.; Anderson, Richard Rox https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8045263 US Patent Document 8,045,263	patent	October 2011
Method and an apparatus for localization of single dye molecules in the fluorescent microscopy Lemmer, Paul; Cremer, Christoph; Baddeley, David https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8212866 US Patent Document 8,212,866	patent	July 2012
Multimodal miniature microscope Descour, Michael; Dupuis, Russell; Anslyn, Eric https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030103262 US Patent Application 10/237151; 20030103262	patent-application	June 2003
Graded-index lens microscopes Schnitzer, Mark J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030117715 US Patent Application 10/029576; 20030117715	patent-application	June 2003
Imaging system with an integrated source and detector array Olszak, Artur G.; Liang, Chen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030222198 US Patent Application 10/158633; 20030222198	patent-application	December 2003
Ingestible pill Kimchy, Yoav; Amrami, Roni; Bouskila, Yona https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040054278 US Patent Application 10/616301; 20040054278	patent-application	March 2004
Fluorescence correlation spectroscopy instrument and method of using the same Wolf, David E.; Bulseco, Dylan A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040080750 US Patent Application 10/633385; 20040080750	patent-application	April 2004
Miniaturized microscope array digital slide scanner Weinstein, Ronald S.; Descoour, Michael R.; Liang, Chen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040101210 US Patent Application 10/637486; 20040101210	patent-application	May 2004
Imaging system, methodology, and applications employing reciprocal space optical design Cartlidge, Andrew G.; Fein, Howard https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040159772 US Patent Application 10/758739; 20040159772	patent-application	August 2004
Wireless in-vivo information acquiring system and external device Shimizu, Hatsuo; Nakatsuchi, KAzutaka https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040215084 US Patent Application 10/830789; 20040215084	patent-application	October 2004
Wireless in-vivo information acquiring system and body-insertable device Shimizu, Hatsuo; Nakatsuchi, Kazutaka https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040225184 US Patent Application 10/830791; 20040225184	patent-application	November 2004
Examination systems for biological samples Neagle, Bradley D.; Schroeder, Kirk S.; Seldin, John H. 03/10/2005, vp https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050051723 US Patent Application 10/898012; 20050051723	patent-application
Laser crystallization apparatus and laser crystallization method Takami, Yoshio https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050199596 US Patent Application 11/074054; 20050199596	patent-application	September 2005
Ingestible device platform for the colon Zilberstein, Yoel; Nagler, Michael; Rousso, Benny https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050266074 US Patent Application 11/132320; 20050266074	patent-application	December 2005
Depth-of-Field Micron Resolution Velocimetry with Pulsed Images of Injected Solid Particles Meinhart, Carl D.; Santiago, Juan G.; Adrian, Ronald J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060049369 US Patent Application 10/713672; 20060049369	patent-application	March 2006
Optical delivery systems and methods of providing adjustable beam diameter, spot size and/or spot shape Andersen, Dan E.; Angeley, David G.; Gooding, Philip https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070189664 US Patent Application 11/653663; 20070189664	patent-application	August 2007
Dynamic optical surgical system utilizing a fixed relationship between target tissue visualization and beam delivery Andersen, Dan; Angeley, David G. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080033406 US Patent Application 11/789964; 20080033406	patent-application	February 2008
Microfluidic flow cytometer and applications of same Li, Dongqing https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080070311 US Patent Application 11/523796; 20080070311	patent-application	March 2008
Miniature microscope camera O'Connell, Dan; Bora, Terry https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080204551 US Patent Application 11/907828; 20080204551	patent-application	August 2008
Systems and methods for volumetric tissue scanning microscopy So, Peter; Engelward, Bevin; Ragan, Timothy https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090072171 US Patent Application 12/152136; 20090072171	patent-application	March 2009
Portable Detection Device for Detecting on the Ground Elements Marked by Fluorescence De Lamberterie, Sebastian https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090127475 US Patent Application 11/795766; 20090127475	patent-application	May 2009
Optical System and Method for Inspecting Fluorescently Labeled Biological Specimens Palti-Wasserman, Daphna; Kober, Yaron https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090161103 US Patent Application 12/390784; 20090161103	patent-application	June 2009
Light Source LaPlante, Mark; Kiegle, Edward; Reichman, Jay https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090201577 US Patent Application 12/205383; 20090201577	patent-application	August 2009
Method and an Apparatus for Localization of Single Dye Molecules in the Fluorescent Microscopy Lemmer, Paul; Cremer, Christoph; Baddeley, David https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090237501 US Patent Application 12/404488; 20090237501	patent-application	September 2009
Mirror Adapted in Microscope to Perform SERS, a Microscope and Methods Thereof Narayana, Chandrabhas; Kumar, GopaLapura Venkataramu Pavan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090244534 US Patent Application 12/203185; 20090244534	patent-application	October 2009
System and Method for Large Field of View, Single Cell Analysis Bawendi, Moungi G.; Ferrer, Jorge M.; Lee, W. David https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090299196 US Patent Application 12/469395; 20090299196	patent-application	December 2009
Microscope for Conventional Fluorescence Microscopy and Total Internal Reflection Microscopy Hecker, Andreas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100118394 US Patent Application 12/526777; 20100118394	patent-application	May 2010
Devices and Methods for Optoelectronic Manipulation of Small Particles Lau, Aldrich N. K.; Yang, Joon Mo; Phan, Huan L. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100206731 US Patent Application 12/702137; 20100206731	patent-application	August 2010
Disposable Microscope and Portable Display Farr, Mina https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100208054 US Patent Application 12/771087; 20100208054	patent-application	August 2010
Method and Systems for Reducing Scanner Image Distortion Osipchuk, Yuri Vladimirovich https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100259805 US Patent Application 12/759136; 20100259805	patent-application	October 2010
Confocal Photoacoustic Microscopy with Optical Lateral Resolution Wang, Lihong; Maslov, Konstantin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100268042 US Patent Application 12/739589; 20100268042	patent-application	October 2010
Integrated semiconductor optical sensors for cellular and neural imaging Levi, Ofer; Lee, Thomas T.; Lee, Meredith M. Applied Optics, Vol. 46, Issue 10, p. 1881-1889 https://doi.org/10.1364/AO.46.001881	journal	April 2007
High-speed, miniaturized fluorescence microscopy in freely moving mice Flusberg, Benjamin A.; Nimmerjahn, Axel; Cocker, Eric D. Nature Methods, Vol. 5, Issue 11 https://doi.org/10.1038/nmeth.1256	journal	October 2008
Miniaturized integration of a fluorescence microscope Ghosh, Kunal K.; Burns, Laurie D.; Cocker, Eric D. Nature Methods, Vol. 8, Issue 10, p. 871-878 https://doi.org/10.1038/nmeth.1694	journal	September 2011
Digital camera system on a chip Fossum, E. R. IEEE Micro, Vol. 18, Issue 3 https://doi.org/10.1109/40.683047	journal	January 1998
CMOS image sensors: State-of-the-art Theuwissen, Albert J. P. Solid-State Electronics, Vol. 52, Issue 9, p. 1401-1406 https://doi.org/10.1016/j.sse.2008.04.012	journal	September 2008
A Miniature Head-Mounted Two-Photon Microscope Helmchen, Fritjof; Fee, Michale S.; Tank, David W. Neuron, Vol. 31, Issue 6, p. 903-912 https://doi.org/10.1016/S0896-6273(01)00421-4	journal	September 2001
Voltage sensitive dye imaging system for awake and freely moving animals Park, Joon Hyuk; Culurciello, Eugenio; Kim, Dongsoo 2008 IEEE Biomedical Circuits and Systems Conference https://doi.org/10.1109/BIOCAS.2008.4696881	conference	November 2008
High-speed fluorescence imaging system for freely moving animals Park, Joon Hyuk; Pieribone, Vincent; Kim, Dongsoo 2009 IEEE International Symposium on Circuits and Systems https://doi.org/10.1109/ISCAS.2009.5118291	conference	May 2009
Listening to Brain Microcircuits for Interfacing With External World—Progress in Wireless Implantable Microelectronic Neuroengineering Devices Nurmikko, Arto V.; Donoghue, John P.; Hochberg, Leigh R. Proceedings of the IEEE, Vol. 98, Issue 3, p. 375-388 https://doi.org/10.1109/JPROC.2009.2038949	journal	March 2010
Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile Mice Dombeck, Daniel A.; Khabbaz, Anton N.; Collman, Forrest Neuron, Vol. 56, Issue 1, p. 43-57 https://doi.org/10.1016/j.neuron.2007.08.003	journal	October 2007
In vivo brain imaging using a portable 29 g two-photon microscope based on a microelectromechanical systems scanning mirror Piyawattanametha, Wibool; Cocker, Eric D.; Burns, Laurie D. Optics Letters, Vol. 34, Issue 15, p. 2309-2311 https://doi.org/10.1364/OL.34.002309	journal	August 2009
Visually evoked activity in cortical cells imaged in freely moving animals Sawinski, J.; Wallace, D. J.; Greenberg, D. S. Proceedings of the National Academy of Sciences, Vol. 106, Issue 46, p. 19557-19562 https://doi.org/10.1073/pnas.0903680106	journal	November 2009
Spatiotemporal Dynamics of Cortical Sensorimotor Integration in Behaving Mice Ferezou, Isabelle; Haiss, Florent; Gentet, Luc J. Neuron, Vol. 56, Issue 5, p. 907-923 https://doi.org/10.1016/j.neuron.2007.10.007	journal	December 2007
Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus Andersson, G.; Oscarsson, O. Experimental Brain Research, Vol. 32, Issue 4, p. 565-579 https://doi.org/10.1007/BF00239553	journal	August 1978
Complex spikes in Purkinje cells in the lateral vermis (b zone) of the cat cerebellum during locomotion. Andersson, G.; Armstrong, D. M. The Journal of Physiology, Vol. 385, Issue 1, p. 107-134 https://doi.org/10.1113/jphysiol.1987.sp016487	journal	April 1987
Anatomical and physiological foundations of cerebellar information processing Apps, Richard; Garwicz, Martin Nature Reviews Neuroscience, Vol. 6, Issue 4, p. 297-311 https://doi.org/10.1038/nrn1646	journal	March 2005
Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy Barretto, Robert P. J.; Ko, Tony H.; Jung, Juergen C. Nature Medicine, Vol. 17, Issue 2, p. 223-228 https://doi.org/10.1038/nm.2292	journal	January 2011
Mobile Phone Based Clinical Microscopy for Global Health Applications Breslauer, David N.; Maamari, Robi N.; Switz, Neil A. PLoS ONE, Vol. 4, Issue 7, Article No. e6320 https://doi.org/10.1371/journal.pone.0006320	journal	July 2009
Temporal Structure of Receptor Neuron Input to the Olfactory Bulb Imaged in Behaving Rats Carey, Ryan M.; Verhagen, Justus V.; Wesson, Daniel W. Journal of Neurophysiology, Vol. 101, Issue 2, p. 1073-1088 https://doi.org/10.1152/jn.90902.2008	journal	February 2009
CMOS image sensors El Gamal, A.; Eltoukhy, H. IEEE Circuits and Devices Magazine, Vol. 21, Issue 3, p. 6-20 https://doi.org/10.1109/MCD.2005.1438751	journal	May 2005
Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo Engelbrecht, Christoph J.; Johnston, Richard S.; Seibel, Eric J. Optics Express, Vol. 16, Issue 8, 5556 https://doi.org/10.1364/OE.16.005556	journal	January 2008
In vivo brain imaging using a portable 39 gram two-photon fluorescence microendoscope Flusberg, Benjamin A.; Jung, Juergen C.; Cocker, Eric D. Optics Letters, Vol. 30, Issue 17, p. 2272-2274 https://doi.org/10.1364/OL.30.002272	journal	September 2005
The isochronic band hypothesis and climbing fibre regulation of motricity: an experimental study: Global patterns of climbing fibre activity Fukuda, Masaji; Yamamoto, Tomoya; Llinás, Rodolfo European Journal of Neuroscience, Vol. 13, Issue 2, p. 315-326 https://doi.org/10.1046/j.0953-816X.2000.01394.x	journal	July 2009
Functional localization in the cerebellum. I. Organization in longitudinal cortico-nuclear zones and their contribution to the control of posture, both extrapyramidal and pyramidal Chambers, W. W.; Sprague, James M. The Journal of Comparative Neurology, Vol. 103, Issue 1, p. 105-129 https://doi.org/10.1002/cne.901030107	journal	August 1955
Microscopic marvels: Microscope for the masses Hayden, Erika Check Nature, Vol. 459, Issue 7247 https://doi.org/10.1038/459632a	journal	June 2009
Optofluidic microscopy—a method for implementing a high resolution optical microscope on a chip Heng, Xin; Erickson, David; Baugh, L. Ryan Lab Chip, Vol. 6, Issue 10, p. 1274-1276 https://doi.org/10.1039/B604676B	journal	January 2006
Functional organization of climbing fibre projection to the cerebellar anterior lobe of the rat Jörntell, H.; Ekerot, C.-F.; Garwicz, M. The Journal of Physiology, Vol. 522, Issue 2, p. 297-309 https://doi.org/10.1111/j.1469-7793.2000.00297.x	journal	January 2000
In Vivo Mammalian Brain Imaging Using One- and Two-Photon Fluorescence Microendoscopy Jung, Juergen C.; Mehta, Amit D.; Aksay, Emre Journal of Neurophysiology, Vol. 92, Issue 5, p. 3121-3133 https://doi.org/10.1152/jn.00234.2004	journal	November 2004
Arraycount, an algorithm for automatic cell counting in microwell arrays Kachouie, Nezamoddin N.; Kang, Lifeng; Khademhosseini, Ali BioTechniques, Vol. 47, Issue 3S https://doi.org/10.2144/000113202	journal	September 2009
Inhibitory Cerebello-Olivary Projections and Blocking Effect in Classical Conditioning Kim, J. J. Science, Vol. 279, Issue 5350, p. 570-573 https://doi.org/10.1126/science.279.5350.570	journal	January 1998
Somatotopic studies on the vermal cortex of the cerebellar anterior lobe of unanaesthetized cats Leicht, R.; Schmidt, R.F. Experimental Brain Research, Vol. 27, Issue 5, p. 479-490 https://doi.org/10.1007/BF00239037	journal	April 1977
Interpreting the BOLD Signal Logothetis, Nikos K.; Wandell, Brian A. Annual Review of Physiology, Vol. 66, Issue 1 https://doi.org/10.1146/annurev.physiol.66.082602.092845	journal	March 2004
erbb3 and erbb2 Are Essential for Schwann Cell Migration and Myelination in Zebrafish Lyons, David A.; Pogoda, Hans-Martin; Voas, Matthew G. Current Biology, Vol. 15, Issue 6, p. 513-524 https://doi.org/10.1016/j.cub.2005.02.030	journal	March 2005
A genetically encoded calcium indicator for chronic in vivo two-photon imaging Mank, Marco; Santos, Alexandre Ferrão; Direnberger, Stephan Nature Methods, Vol. 5, Issue 9, p. 805-811 https://doi.org/10.1038/nmeth.1243	journal	August 2008
Automated Analysis of Cellular Signals from Large-Scale Calcium Imaging Data Mukamel, Eran A.; Nimmerjahn, Axel; Schnitzer, Mark J. Neuron, Vol. 63, Issue 6, p. 747-760 https://doi.org/10.1016/j.neuron.2009.08.009	journal	September 2009
Dendritic encoding of sensory stimuli controlled by deep cortical interneurons Murayama, Masanori; Pérez-Garci, Enrique; Nevian, Thomas Nature, Vol. 457, Issue 7233, p. 1137-1141 https://doi.org/10.1038/nature07663	journal	January 2009
Motor Behavior Activates Bergmann Glial Networks Nimmerjahn, Axel; Mukamel, Eran A.; Schnitzer, Mark J. Neuron, Vol. 62, Issue 3, p. 400-412 https://doi.org/10.1016/j.neuron.2009.03.019	journal	May 2009
Identification and Clustering of Event Patterns From In Vivo Multiphoton Optical Recordings of Neuronal Ensembles Ozden, Ilker; Lee, H. Megan; Sullivan, Megan R. Journal of Neurophysiology, Vol. 100, Issue 1, p. 495-503 https://doi.org/10.1152/jn.01310.2007	journal	July 2008
Reliable Coding Emerges from Coactivation of Climbing Fibers in Microbands of Cerebellar Purkinje Neurons Ozden, I.; Sullivan, M. R.; Lee, H. M. Journal of Neuroscience, Vol. 29, Issue 34, p. 10463-10473 https://doi.org/10.1523/JNEUROSCI.0967-09.2009	journal	August 2009
High-throughput fluorescence microscopy for systems biology Pepperkok, Rainer; Ellenberg, Jan Nature Reviews Molecular Cell Biology, Vol. 7, Issue 9, p. 690-696 https://doi.org/10.1038/nrm1979	journal	July 2006
A genetic screen identifies genes essential for development of myelinated axons in zebrafish Pogoda, Hans-Martin; Sternheim, Nitzan; Lyons, David A. Developmental Biology, Vol. 298, Issue 1, p. 118-131 https://doi.org/10.1016/j.ydbio.2006.06.021	journal	October 2006
The Cerebellum: A Neuronal Learning Machine? Raymond, J. L.; Lisberger, S. G.; Mauk, M. D. Science, Vol. 272, Issue 5265 https://doi.org/10.1126/science.272.5265.1126	journal	May 1996
Imaging performance of a miniature integrated microendoscope Rogers, Jeremy D.; Landau, Sara; Tkaczyk, Tomasz S. Journal of Biomedical Optics, Vol. 13, Issue 5, Article No. 054020 https://doi.org/10.1117/1.2978060	journal	September 2008
A Role for the Cerebellum in Learning Movement Coordination Thach, W.T. Neurobiology of Learning and Memory, Vol. 70, Issue 1-2, p. 177-188 https://doi.org/10.1006/nlme.1998.3846	journal	July 1998
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators Tian, Lin; Hires, S Andrew; Mao, Tianyi Nature Methods, Vol. 6, Issue 12, p. 875-881 https://doi.org/10.1038/nmeth.1398	journal	November 2009
Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning Wang, Thomas D.; Contag, Christopher H.; Mandella, Michael J. Journal of Biomedical Optics, Vol. 9, Issue 4, p. 735-742 https://doi.org/10.1117/1.1760760	journal	January 2004
Dynamic organization of motor control within the olivocerebellar system Welsh, John P.; Lang, Eric J.; Suglhara, Izumi Nature, Vol. 374, Issue 6521 https://doi.org/10.1038/374453a0	journal	March 1995
Advances in Light Microscopy for Neuroscience Wilt, Brian A.; Burns, Laurie D.; Wei Ho, Eric Tatt Annual Review of Neuroscience, Vol. 32, Issue 1, p. 435-506 https://doi.org/10.1146/annurev.neuro.051508.135540	journal	June 2009
The application of Fresnel zone plate based projection in optofluidic microscopy Wu, Jigang; Cui, Xiquan; Lee, Lap Man Optics Express, Vol. 16, Issue 20, p. 15595-15602 https://doi.org/10.1364/OE.16.015595	journal	September 2008

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Microscopy imaging device with advanced imaging properties Ghosh, Kunal; Burns, Laurie; El Gamal, Abbas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9474448 US Patent Document 9,474,448	patent	October 2016

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