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Title: Enhanced spot preparation for liquid extractive sampling and analysis

Patent ·
OSTI ID:1215631
;

A method for performing surface sampling of an analyte, includes the step of placing the analyte on a stage with a material in molar excess to the analyte, such that analyte-analyte interactions are prevented and the analyte can be solubilized for further analysis. The material can be a matrix material that is mixed with the analyte. The material can be provided on a sample support. The analyte can then be contacted with a solvent to extract the analyte for further processing, such as by electrospray mass spectrometry.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-00OR22725
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
9,140,633
Application Number:
13/488,141
OSTI ID:
1215631
Resource Relation:
Patent File Date: 2012 Jun 04
Country of Publication:
United States
Language:
English

References (12)

Rapid detection of analytes with receptors immobilized on soluble submicron particles patent April 1999
Method and device for the detection of analyte in a fluid test sample patent April 2001
Sampling probe for microarray read out using electrospray mass spectrometry patent October 2004
Matrix-free desorption ionization mass spectrometry using tailored morphology layer devices patent October 2006
Automated position control of a surface array relative to a liquid microjunction surface sampler patent November 2007
Sampling probe for microarray read out using electrospray mass spectrometry patent-application October 2003
Control of the positional relationship between a sample collection instrument and a surface to be analyzed during a sampling procedure with image analysis patent-application January 2010
Method and system for formation and withdrawal of a sample from a surface to be analyzed patent-application September 2010
Nanostructured substrates for surface enhanced Raman spectroscopy (SERS) and detection of biological and chemical analytes by electrical double layer (EDL) capacitance patent-application March 2011
Liquid Microjunction Surface Sampling Probe Fluid Dynamics: Computational and Experimental Analysis of Coaxial Intercapillary Positioning Effects on Sample Manipulation journal April 2011
High-Throughput Mode Liquid Microjunction Surface Sampling Probe journal August 2009
Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform journal March 2010

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY