Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions

Natarajan, Padmaja; Punta, Marco; Kumar, Abhinav; Yeh, Andrew P; Godzik, Adam; Aravind, L.

doi:10.1186/s12859-014-0434-7

Title: Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions

Journal Article · Fri Jan 16 00:00:00 EST 2015 · BMC Bioinformatics

DOI:https://doi.org/10.1186/s12859-014-0434-7· OSTI ID:1208934

Natarajan, Padmaja ^[1]; Punta, Marco ^[2]; Kumar, Abhinav ^[3]; Yeh, Andrew P ^[3]; Godzik, Adam ^[1]; Aravind, L. ^[4]

Joint Center for Structural Genomics, San Diego, CA (United States); Sanford-Burnham Medical Research Inst., La Jolla, CA (United States)
European Bioinformatics Inst., Cambridgeshire (United Kingdom). European Molecular Lab., Wellcome Trust Genome Campus
Joint Center for Structural Genomics, San Diego, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)
National Library of Medicine, Bethesda, MD (United States)

N-terminal domains of BVU_4064 and BF1687 proteins from Bacteroides vulgatus and Bacteroides fragilis respectively are members of the Pfam family PF12985 (DUF3869). Proteins containing a domain from this family can be found in most Bacteroides species and, in large numbers, in all human gut microbiome samples. Both BVU_4064 and BF1687 proteins have a consensus lipobox motif implying they are anchored to the membrane, but their functions are otherwise unknown. The C-terminal half of BVU_4064 is assigned to protein family PF12986 (DUF3870); the equivalent part of BF1687 was unclassified.

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Research Organization:: SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 1208934

Journal Information:: BMC Bioinformatics, Vol. 16, Issue 1; ISSN 1471-2105

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 5 works

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