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Title: The Coherent X-ray Imaging instrument at the Linac Coherent Light Source

Journal Article · · Journal of Synchrotron Radiation (Online)

The Coherent X-ray Imaging (CXI) instrument specializes in hard X-ray, in-vacuum, high power density experiments in all areas of science. Two main sample chambers, one containing a 100 nm focus and one a 1 µm focus, are available, each with multiple diagnostics, sample injection, pump–probe and detector capabilities. The flexibility of CXI has enabled it to host a diverse range of experiments, from biological to extreme matter.

Research Organization:
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Contributing Organization:
SLAC National Accelerator Laboratory, Menlo Park, CA (United States) Linac Coherent Light Source
OSTI ID:
1188712
Journal Information:
Journal of Synchrotron Radiation (Online), Vol. 22, Issue 3; ISSN 1600-5775
Publisher:
International Union of CrystallographyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 129 works
Citation information provided by
Web of Science

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Gas dynamic virtual nozzle for generation of microscopic droplet streams journal September 2008
A single-shot intensity-position monitor for hard x-ray FEL sources conference September 2011
Achieving few-femtosecond time-sorting at hard X-ray free-electron lasers journal February 2013
The CSPAD megapixel x-ray camera at LCLS conference October 2012
CSPAD-140k: A versatile detector for LCLS experiments
  • Herrmann, Sven; Boutet, Sébastien; Duda, Brian
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journal August 2013
Fixed-target protein serial microcrystallography with an x-ray free electron laser journal August 2014
Simultaneous Femtosecond X-ray Spectroscopy and Diffraction of Photosystem II at Room Temperature journal February 2013
In vivo protein crystallization opens new routes in structural biology journal January 2012
Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser journal July 2014
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7 journal June 2008
Serial Femtosecond Crystallography of G Protein-Coupled Receptors journal December 2013
Phaser crystallographic software journal July 2007
Femtosecond Visualization of Lattice Dynamics in Shock-Compressed Matter journal October 2013
Potential for biomolecular imaging with femtosecond X-ray pulses journal August 2000
Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser journal November 2012
Nanoflow electrospinning serial femtosecond crystallography journal October 2012
Ultra-precise characterization of LCLS hard X-ray focusing mirrors by high resolution slope measuring deflectometry journal January 2012
Lifetime and damage threshold properties of reflective x-ray coatings for the LCLS free-electron laser conference May 2011
Communication: The electronic structure of matter probed with a single femtosecond hard x-ray pulse journal March 2014
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography journal February 2014
Communication: The electronic structure of matter probed with a single femtosecond hard x-ray pulse text January 2014

Cited By (72)

De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure journal September 2016
Structure of photosystem II and substrate binding at room temperature journal November 2016
Structure of the full-length glucagon class B G-protein-coupled receptor journal May 2017
Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography journal September 2017
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand journal May 2017
Concentric-flow electrokinetic injector enables serial crystallography of ribosome and photosystem II journal November 2015
Liquid explosions induced by X-ray laser pulses journal May 2016
Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons journal September 2017
Relativistic and resonant effects in the ionization of heavy atoms by ultra-intense hard X-rays journal October 2018
Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin journal July 2019
Ultrafast X-ray scattering reveals vibrational coherence following Rydberg excitation journal July 2019
Focal Spot and Wavefront Sensing of an X-Ray Free Electron laser using Ronchi shearing interferometry journal October 2017
Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography journal February 2018
Towards in cellulo virus crystallography journal February 2018
A statistical approach to detect protein complexes at X-ray free electron laser facilities journal December 2018
Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source journal August 2016
Se-SAD serial femtosecond crystallography datasets from selenobiotinyl-streptavidin journal April 2017
Reproducibility of single protein explosions induced by X-ray lasers journal January 2018
Structural enzymology using X-ray free electron lasers journal December 2016
Ice nucleation rates near ∼225 K journal February 2018
Is radiation damage the limiting factor in high-resolution single particle imaging with X-ray free-electron lasers? journal July 2019
Scattering off molecules far from equilibrium journal August 2019
Ultrafast nonthermal heating of water initiated by an X-ray Free-Electron Laser journal May 2018
Non-cryogenic structure of a chloride pump provides crucial clues to temperature-dependent channel transport efficiency journal November 2018
Strongly aligned gas-phase molecules at free-electron lasers journal September 2015
Design of the mirror optical systems for coherent diffractive imaging at the SPB/SFX instrument of the European XFEL journal June 2016
Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature journal August 2018
ClickX : a visualization-based program for preprocessing of serial crystallography data journal May 2019
Demonstration of simultaneous experiments using thin crystal multiplexing at the Linac Coherent Light Source journal April 2015
The Macromolecular Femtosecond Crystallography Instrument at the Linac Coherent Light Source journal February 2019
Pump–probe experimental methodology at the Linac Coherent Light Source journal April 2019
In-plane wavevector distribution in partially coherent X-ray propagation journal June 2019
Structure-factor amplitude reconstruction from serial femtosecond crystallography of two-dimensional membrane-protein crystals journal January 2019
SPIND : a reference-based auto-indexing algorithm for sparse serial crystallography data journal January 2019
A fixed-target platform for serial femtosecond crystallography in a hydrated environment journal January 2020
Transient lattice contraction in the solid-to-plasma transition journal January 2016
A deep UV trigger for ground-state ring-opening dynamics of 1,3-cyclohexadiene journal September 2019
Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation journal September 2015
Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein journal May 2016
Data systems for the Linac coherent light source journal January 2017
Macromolecular diffractive imaging using imperfect crystals text January 2016
Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography text January 2016
Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene text January 2018
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser text January 2018
Stimulated X-Ray Emission Spectroscopy in Transition Metal Complexes text January 2018
Photon Beam Transport and Scientific Instruments at the European XFEL journal June 2017
Pump-Probe Time-Resolved Serial Femtosecond Crystallography at SACLA: Current Status and Data Collection Strategies journal December 2019
Diffraction data of core-shell nanoparticles from an X-ray free electron laser journal April 2017
Double-flow focused liquid injector for efficient serial femtosecond crystallography journal March 2017
Optical laser systems at the Linac Coherent Light Source journal April 2015
Transient lattice contraction in the solid-to-plasma transition text January 2016
Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source text January 2016
Structure-factor amplitude reconstruction from serial femtosecond crystallography of two-dimensional membrane-protein crystals text January 2019
Reproducibility of single protein explosions induced by X-ray lasers text January 2018
A fixed-target platform for serial femtosecond crystallography in a hydrated environment text January 2020
X-ray diffractive imaging of controlled gas-phase molecules: Toward imaging of dynamics in the molecular frame text January 2020
Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography text January 2016
Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons text January 2017
Strategies for sample delivery for femtosecond crystallography text January 2019
Structural enzymology using X-ray free electron lasers text January 2017
Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature journal April 2019
Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene journal May 2018
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser journal June 2018
Structure of the 30S ribosomal decoding complex at ambient temperature journal August 2018
Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography text January 2018
Is radiation damage the limiting factor in high-resolution single particle imaging with X-ray free-electron lasers? text January 2019
X-ray diffractive imaging of controlled gas-phase molecules: Toward imaging of dynamics in the molecular frame journal February 2020
Ultrafast nonthermal heating of water initiated by an X-ray Free-Electron Laser text January 2018
Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography journal May 2018
Relativistic and resonant effects in the ionization of heavy atoms by ultra-intense hard X-rays text January 2018
Strongly aligned gas-phase molecules at Free-Electron Lasers text January 2015
Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin text January 2019