Photoreactive synthetic regulator of protein function and methods of use thereof

Trauner, Dirk; Isacoff, Ehud Y; Kramer, Richard H; Banghart, Matthew R; Fortin, Doris L; Mourot, Alexandre

Title: Photoreactive synthetic regulator of protein function and methods of use thereof

Patent · Tue Mar 31 00:00:00 EDT 2015

OSTI ID:1177034

Trauner, Dirk; Isacoff, Ehud Y; Kramer, Richard H; Banghart, Matthew R; Fortin, Doris L; Mourot, Alexandre

The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,993,736

Application Number:: 13/059,052

OSTI ID:: 1177034

Resource Relation:: Patent File Date: 2010 May 06

Country of Publication:: United States

Language:: English

References (11)

Light-activated ion channels for remote control of neuronal firing Banghart, Matthew; Borges, Katharine; Isacoff, Ehud Nature Neuroscience, Vol. 7, Issue 12 https://doi.org/10.1038/nn1356	journal	November 2004
Photochromic Activators of the Acetylcholine Receptor Bartels, E.; Wassermann, N. H.; Erlanger, B. F. Proceedings of the National Academy of Sciences, Vol. 68, Issue 8 https://doi.org/10.1073/pnas.68.8.1820	journal	August 1971
A Light-Modulated Sequence-Specific DNA-Binding Peptide Caamaño, Ana M.; Vázquez, M. Eugenio; Martínez-Costas, José Angewandte Chemie, Vol. 39, Issue 17 https://doi.org/10.1002/1521-3773(20000901)39:17<3104::AID-ANIE3104>3.0.CO;2-0	journal	September 2000
Light Control of Mitochondrial Complex I Activity by a Photoresponsive Inhibitor ^† Fujita, Daisuke; Murai, Masatoshi; Nishioka, Takaaki Biochemistry, Vol. 45, Issue 21 https://doi.org/10.1021/bi060544z	journal	May 2006
Optical Switches for Remote and Noninvasive Control of Cell Signaling Gorostiza, P.; Isacoff, E. Y. Science, Vol. 322, Issue 5900 https://doi.org/10.1126/science.1166022	journal	October 2008
Photoregulation of an Enzymic Process by Means of a Light-Sensitive Ligand Kaufman, H.; Vratsanos, S. M.; Erlanger, B. F. Science, Vol. 162, Issue 3861 https://doi.org/10.1126/science.162.3861.1487	journal	December 1968
A covalently bound photoisomerizable agonist. Comparison with reversibly bound agonists at electrophorus electroplaques Lester, H. The Journal of General Physiology, Vol. 75, Issue 2 https://doi.org/10.1085/jgp.75.2.207	journal	February 1980
Biologically Active Molecules with a “Light Switch” Mayer, Günter; Heckel, Alexander Angewandte Chemie International Edition, Vol. 45, Issue 30, p. 4900-4921 https://doi.org/10.1002/anie.200600387	journal	July 2006
Allosteric control of an ionotropic glutamate receptor with an optical switch Volgraf, Matthew; Gorostiza, Pau; Numano, Rika Nature Chemical Biology, Vol. 2, Issue 1 https://doi.org/10.1038/nchembio756	journal	December 2005
Blockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes French, R. J.; Shoukimas, J. J. Biophysical Journal, Vol. 34, Issue 2, p. 271-291 https://doi.org/10.1016/S0006-3495(81)84849-7	journal	May 1981
Kinetics of Inward-Rectifier K ⁺ Channel Block by Quaternary Alkylammonium Ions : Dimension and Properties of the Inner Pore Guo, Donglin; Lu, Zhe The Journal of General Physiology, Vol. 117, Issue 5 https://doi.org/10.1085/jgp.117.5.395	journal	April 2001

Cited By (1)

Photoreactive synthetic regulator of protein function and methods of use thereof Trauner, Dirk; Isacoff, Ehud Y.; Kramer, Richard H. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8993736 US Patent Document 8,993,736	patent	March 2015

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