Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17

Gray, Joe W.; Pinkel, Daniel; Kallioniemi, Olli-Pekka; Kallioniemi, Anne; Sakamoto, Masaru

Title: Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17

Patent · Tue Sep 09 00:00:00 EDT 2008

OSTI ID:1176710

Gray, Joe W.; Pinkel, Daniel; Kallioniemi, Olli-Pekka; Kallioniemi, Anne; Sakamoto, Masaru

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: RE40494

Application Number:: 11/398,456

OSTI ID:: 1176710

Resource Relation:: Patent File Date: 2006 Apr 04

Country of Publication:: United States

Language:: English

References (110)

On the heterogeneity of the slow reassociating (?unique?) DNA Ivanov, IvanG.; Markov, GeorgeG. Molecular and Cellular Biochemistry, Vol. 20, Issue 2 https://doi.org/10.1007/BF00241389	journal	June 1978
Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia. Erikson, J.; Griffin, C. A.; ar-Rushdi, A. Proceedings of the National Academy of Sciences, Vol. 83, Issue 6 https://doi.org/10.1073/pnas.83.6.1807	journal	March 1986
Cytogenetic profiling using fluorescencein situ hybridization (FISH) and comparative genomic hybridization (CGH) Thompson, Curtis T.; Gray, Joe W. Journal of Cellular Biochemistry, Vol. 53, Issue S17G https://doi.org/10.1002/jcb.240531127	journal	January 1993
Preparative dual-beam sorting of the human Y chromosome and in situ hybridization of cloned DNA probes Cremer, C.; Rappold, G.; Gray, J. W. Cytometry, Vol. 5, Issue 6 https://doi.org/10.1002/cyto.990050604	journal	November 1984
Detection of the Philadelphia chromosome in interphase nuclei Arnoldus, E. P. J.; Wiegant, J.; Noordermeer, I. A. Cytogenetic and Genome Research, Vol. 54, Issue 3-4 https://doi.org/10.1159/000132972	journal	January 1990
[38] Nucleic acid hybridization in cytological preparations Gall, Joseph G.; Pardue, Mary Lou Methods in Enzymology https://doi.org/10.1016/S0076-6879(71)21040-5	book	January 1971
Kinetics for Hybridization of Peptide Nucleic Acids (PNA) with DNA and RNA Studied with the BIAcore Technique ^† Jensen, Kristine Kilså; Ørum, Henrik; Nielsen, Peter E. Biochemistry, Vol. 36, Issue 16 https://doi.org/10.1021/bi9627525	journal	April 1997
A direct estimate of the number of human γ-globin genes Old, John; Clegg, J. B.; Weatherall, D. J. Cell, Vol. 8, Issue 1 https://doi.org/10.1016/0092-8674(76)90180-X	journal	May 1976
Chromosomal localization of a single copy gene by in situ hybridization - human ? globin genes on the short arm of chromosome 11 Malcolm, S.; Barton, P.; Murphy, C. Annals of Human Genetics, Vol. 45, Issue 2 https://doi.org/10.1111/j.1469-1809.1981.tb00315.x	journal	May 1981
Four restriction fragment length polymorphisms revealed by probes from a single cosmid map to human chromosome 12q Buroker, N. E.; Magenis, R. E.; Weliky, K. Human Genetics, Vol. 72, Issue 1 https://doi.org/10.1007/BF00278825	journal	January 1986
Autoradiographic Detection of Molecular Hybrids between rRNA and DNA in Tissue Sections Buongiorno-Nardelli, M.; Amaldi, F. Nature, Vol. 225, Issue 5236 https://doi.org/10.1038/225946a0	journal	March 1970
Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization Tkachuk, D.; Westbrook, C.; Andreeff, M. Science, Vol. 250, Issue 4980 https://doi.org/10.1126/science.2237408	journal	October 1990
The application of DNA recombinant technology to the analysis of the human genome and genetic disease Davies, Kay E. Human Genetics, Vol. 58, Issue 4 https://doi.org/10.1007/BF00282814	journal	October 1981
Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes Rappold, G. A.; Cremer, T.; Hager, H. D. Human Genetics, Vol. 67, Issue 3 https://doi.org/10.1007/BF00291361	journal	August 1984
Quantitative in situ hybridization of ribosomal RNA species to polytene chromosomes of Drosophila melanogaster Szabo, Paul; Elder, Robert; Steffensen, Dale M. Journal of Molecular Biology, Vol. 115, Issue 3 https://doi.org/10.1016/0022-2836(77)90170-X	journal	September 1977
Fluorescence In Situ Hybridization Wolff, Daynna J.; Schwartz, Stuart The Principles of Clinical Cytogenetics https://doi.org/10.1385/1-59259-833-1:455	book	January 2005
Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia Bartram, Claus R.; de Klein, Annelies; Hagemeijer, Anne Nature, Vol. 306, Issue 5940 https://doi.org/10.1038/306277a0	journal	November 1983
ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Kallioniemi, O. P.; Kallioniemi, A.; Kurisu, W. Proceedings of the National Academy of Sciences, Vol. 89, Issue 12 https://doi.org/10.1073/pnas.89.12.5321	journal	June 1992
Cytological Hybridization to Mammalian Chromosomes Hendkrson, Ann S. International Review of Cytology Volume 76 https://doi.org/10.1016/S0074-7696(08)61787-8	book	January 1982
The 200-kb segmental duplication on human chromosome 21 originates from a pericentromeric dissemination involving human chromosomes 2, 18 and 13 Golfier, Geoffroy; Chibon, Frédéric; Aurias, Alain Gene, Vol. 312 https://doi.org/10.1016/S0378-1119(03)00673-5	journal	July 2003
A Limited Number of Globin Genes in Human DNA Gambino, R.; Kacian, D.; O'Donnell, J. Proceedings of the National Academy of Sciences, Vol. 71, Issue 10 https://doi.org/10.1073/pnas.71.10.3966	journal	October 1974
Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84 Cremer, T.; Landegent, J.; Brückner, A. Human Genetics, Vol. 74, Issue 4 https://doi.org/10.1007/BF00280484	journal	December 1986
Translocation of c-myc in the hereditary renal cell carcinoma associated with a t(3;8)(p14.2;q24.13) chromosomal translocation. Drabkin, H. A.; Bradley, C.; Hart, I. Proceedings of the National Academy of Sciences, Vol. 82, Issue 20 https://doi.org/10.1073/pnas.82.20.6980	journal	October 1985
Interphase cytogenetics in pathology: principles, methods, and applications of fluorescence in situ hybridization (FISH) Werner, M.; Wilkens, L.; Aubele, Michaela Histochemistry and Cell Biology, Vol. 108, Issue 4-5 https://doi.org/10.1007/s004180050179	journal	October 1997
Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization Harper, Mary E.; Saunders, Grady F. Chromosoma, Vol. 83, Issue 3 https://doi.org/10.1007/BF00327364	journal	July 1981
Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization Landegent, J. E.; Jansen in de Wal, N.; Fisser-Groen, Y. M. Human Genetics, Vol. 73, Issue 4 https://doi.org/10.1007/BF00279100	journal	August 1986
Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Pinkel, D.; Straume, T.; Gray, J. W. Proceedings of the National Academy of Sciences, Vol. 83, Issue 9 https://doi.org/10.1073/pnas.83.9.2934	journal	May 1986
Organization and heterogeneity of sequences within a repeating unit of human Y chromosome deoxyribonucleic acid Kunkel, Louis M.; Smith, Kirby D.; Boyer, Samuel H. Biochemistry, Vol. 18, Issue 15 https://doi.org/10.1021/bi00582a022	journal	July 1979
Mapping muscle protein genes by in situ hybridization using biotin-labeled probes. Albertson, D. G. The EMBO Journal, Vol. 4, Issue 10 https://doi.org/10.1002/j.1460-2075.1985.tb03961.x	journal	October 1985
Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization Landegent, J. E.; Jansen in de Wal, N.; Dirks, R. W. Human Genetics, Vol. 77, Issue 4 https://doi.org/10.1007/BF00291428	journal	December 1987
A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library Bufton, L.; Mohandas, T. K.; Magenis, R. E. Human Genetics, Vol. 74, Issue 4 https://doi.org/10.1007/BF00280499	journal	December 1986
Detection of chromosome aberrations in interphase tumor nuclei by nonradioactive in situ hybridization Nederlof, Petra M.; van der Flier, Silvia; Raap, Anton K. Cancer Genetics and Cytogenetics, Vol. 42, Issue 1 https://doi.org/10.1016/0165-4608(89)90011-3	journal	October 1989
Chapter 1 Nucleic Acid Hybridization to the DNA of Cytological Preparations Pardue, Mary Lou; Gall, Joseph G. Methods in Cell Biology https://doi.org/10.1016/S0091-679X(08)60727-X	book	January 1975
Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia van der Burg, M.; Poulsen, T. S.; Hunger, S. P. Leukemia, Vol. 18, Issue 5 https://doi.org/10.1038/sj.leu.2403340	journal	March 2004
Human chromosome-specific repetitive DNA sequences: novel markers for genetic analysis Moyzis, R. K.; Albright, K. L.; Bartholdi, M. F. Chromosoma, Vol. 95, Issue 6 https://doi.org/10.1007/BF00333988	journal	October 1987
Chemically modified nucleic acids as immunodetectable probes in hybridization experiments. Tchen, P.; Fuchs, R. P.; Sage, E. Proceedings of the National Academy of Sciences, Vol. 81, Issue 11 https://doi.org/10.1073/pnas.81.11.3466	journal	June 1984
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Wahl, G. M.; Stern, M.; Stark, G. R. Proceedings of the National Academy of Sciences, Vol. 76, Issue 8 https://doi.org/10.1073/pnas.76.8.3683	journal	August 1979
Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes Cremer, T.; Lichter, P.; Borden, J. Human Genetics, Vol. 80, Issue 3 https://doi.org/10.1007/BF01790091	journal	November 1988
Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries Lichter, P.; Cremer, T.; Borden, J. Human Genetics, Vol. 80, Issue 3 https://doi.org/10.1007/BF01790090	journal	November 1988
Formation and Detection of Rna-Dna Hybrid Molecules in Cytological Preparations Gall, J. G.; Pardue, M. L. Proceedings of the National Academy of Sciences, Vol. 63, Issue 2 https://doi.org/10.1073/pnas.63.2.378	journal	June 1969
Hemolytic disease of the newborn caused by a new deletion of the entire beta-globin cluster. Pirastu, M.; Kan, Y. W.; Lin, C. C. Journal of Clinical Investigation, Vol. 72, Issue 2 https://doi.org/10.1172/JCI111008	journal	August 1983
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules Egholm, Michael; Buchardt, Ole; Christensen, Leif Nature, Vol. 365, Issue 6446 https://doi.org/10.1038/365566a0	journal	October 1993
Acceleration of DNA renaturation rates Wetmur, James G. Biopolymers, Vol. 14, Issue 12 https://doi.org/10.1002/bip.1975.360141208	journal	December 1975
Molecular cytogenetics in human cancer diagnosis Gray, Joe W.; Pinkel, Daniel Cancer, Vol. 69, Issue S6, p. 1536-1542 https://doi.org/10.1002/1097-0142(19920315)69:6+<1536::AID-CNCR2820691306>3.0.CO;2-J	journal	March 1992
Partial trisomy of the long arm of human chromosome 1 as demonstrated by in situ hybridization with 5S ribosomal RNA Steffensen, Dale M.; Chu, Ernest H. Y.; Speert, David P. Human Genetics, Vol. 36, Issue 1 https://doi.org/10.1007/BF00390432	journal	January 1977
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide Nielsen, P.; Egholm, M.; Berg, R. Science, Vol. 254, Issue 5037 https://doi.org/10.1126/science.1962210	journal	December 1991
Construction of fifteen human chromosome-specific DNA libraries from flow-purified chromosomes Fuscoe, J. C.; Clark, L. M.; Van Dilla, M. A. Cytogenetic and Genome Research, Vol. 43, Issue 1-2 https://doi.org/10.1159/000132301	journal	January 1986
Differential distribution of long and short interspersed element sequences in the mouse genome: chromosome karyotyping by fluorescence in situ hybridization. Boyle, A. L.; Ballard, S. G.; Ward, D. C. Proceedings of the National Academy of Sciences, Vol. 87, Issue 19 https://doi.org/10.1073/pnas.87.19.7757	journal	October 1990
A procedure for the isolation of deoxyribonucleic acid from micro-organisms Marmur, J. Journal of Molecular Biology, Vol. 3, Issue 2 https://doi.org/10.1016/S0022-2836(61)80047-8	journal	April 1961
Hybridization histochemistry Coghlan, J. P.; Aldred, P.; Haralambidis, J. Analytical Biochemistry, Vol. 149, Issue 1 https://doi.org/10.1016/0003-2697(85)90472-5	journal	August 1985
The DNA sequence of human chromosome 21 Hattori, M.; Fujiyama, A.; Taylor, T. D. Nature, Vol. 405, Issue 6784 https://doi.org/10.1038/35012518	journal	May 2000
Fluorescence in situ hybridization with Alu and L1 polymerase chain reaction probes for rapid characterization of human chromosomes in hybrid cell lines. Lichter, P.; Ledbetter, S. A.; Ledbetter, D. H. Proceedings of the National Academy of Sciences, Vol. 87, Issue 17 https://doi.org/10.1073/pnas.87.17.6634	journal	September 1990
A new method for fluorescence microscopical localization of specific DNA sequences by in situ hybridization of fluorochrome-labelled RNA Bauman, J. G. J.; Wiegant, J.; Borst, P. Experimental Cell Research, Vol. 128, Issue 2 https://doi.org/10.1016/0014-4827(80)90087-7	journal	August 1980
Genomic mismatch scanning: a new approach to genetic linkage mapping Nelson, Stanley F.; McCusker, John H.; Sander, Mark A. Nature Genetics, Vol. 4, Issue 1 https://doi.org/10.1038/ng0593-11	journal	May 1993
Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8 Lux, Samuel E.; Tse, William T.; Menninger, Joan C. Nature, Vol. 345, Issue 6277 https://doi.org/10.1038/345736a0	journal	June 1990
General method for cloning amplified DNA by differential screening with genomic probes. Brison, O.; Ardeshir, F.; Stark, G. R. Molecular and Cellular Biology, Vol. 2, Issue 5 https://doi.org/10.1128/MCB.2.5.578	journal	May 1982
A noninvasive method for determination of the sex and karyotype of the fetus from the maternal blood Selypes, A.; Lorencz, R. Human Genetics, Vol. 79, Issue 4 https://doi.org/10.1007/BF00282176	journal	August 1988
Detection of aneuploidy and possible deletion in paraffin-embedded rhabdomyosarcoma cells with FISH Lee, Wonbae; Han, Kyungja; Harris, Charles P. Cancer Genetics and Cytogenetics, Vol. 68, Issue 2 https://doi.org/10.1016/0165-4608(93)90004-6	journal	July 1993
Direct carrier detection by in situ suppression hybridization with cosmid clones of the Duchenne/Becker muscular dystrophy locus Ried, T.; Mahler, V.; Vogt, P. Human Genetics, Vol. 85, Issue 6 https://doi.org/10.1007/BF00193578	journal	October 1990
Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes Rabin, Mark; Hart, Charles P.; Ferguson-Smith, Anne Nature, Vol. 314, Issue 6007 https://doi.org/10.1038/314175a0	journal	March 1985
Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Pinkel, D.; Landegent, J.; Collins, C. Proceedings of the National Academy of Sciences, Vol. 85, Issue 23 https://doi.org/10.1073/pnas.85.23.9138	journal	December 1988
Rapid detection of human chromosome 21 aberrations by in situ hybridization. Lichter, P.; Cremer, T.; Tang, C. J. Proceedings of the National Academy of Sciences, Vol. 85, Issue 24 https://doi.org/10.1073/pnas.85.24.9664	journal	December 1988
In situ hybridization and translocation breakpoint mapping Cannizzaro, L. A.; Aronson, M. M.; Emanuel, B. S. Cytogenetic and Genome Research, Vol. 39, Issue 3 https://doi.org/10.1159/000132130	journal	January 1985
Multiple sex chromosomes in Drosophila miranda: A system to study the degeneration of a chromosome Steinemann, M. Chromosoma, Vol. 86, Issue 1 https://doi.org/10.1007/BF00330730	journal	September 1982
Chemical synthesis of oligonucleotides containing a free sulphydryl group and subsequent attachment of thiol specific probes Connolly, Bernard A.; Rider, Peter Nucleic Acids Research, Vol. 13, Issue 12 https://doi.org/10.1093/nar/13.12.4485	journal	January 1985
Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors Kallioniemi, Olli-P.; Kallioniemi, Anne; Piper, Jim Genes, Chromosomes and Cancer, Vol. 10, Issue 4 https://doi.org/10.1002/gcc.2870100403	journal	August 1994
One FISH, two FISH, red FISH, blue FISH Le Beau, Michelle M. Nature Genetics, Vol. 12, Issue 4 https://doi.org/10.1038/ng0496-341	journal	April 1996
Analysis of a dispersed repetitive DNA sequence in isogenic lines of Drosophila Pierce, Dorothy A.; Lucchesi, John C. Chromosoma, Vol. 82, Issue 4 https://doi.org/10.1007/BF00295007	journal	May 1981
Cytogenetics of the parthenogenetic grasshopper Warramaba virgo and its bisexual relatives: VII. Evidence from repeated DNA sequences for a dual origin of W. virgo Dennis, E. S.; Peacock, W. J.; White, M. J. D. Chromosoma, Vol. 82, Issue 4 https://doi.org/10.1007/BF00295006	journal	May 1981
Denaturation, renaturation, and loss of DNA during in situ hybridization procedures Raap, A. K.; Marijnen, J. G. J.; Vrolijk, J. Cytometry, Vol. 7, Issue 3 https://doi.org/10.1002/cyto.990070303	journal	May 1986
Removal of repeated sequences from hybridisation probes Sealey, Paul G.; Whittaker, Paul A.; Southern, Edwin M. Nucleic Acids Research, Vol. 13, Issue 6 https://doi.org/10.1093/nar/13.6.1905	journal	January 1985
Improved technique for analysis of formalin-fixed, paraffin-embedded tumors by fluorescence in situ hybridization Hyytinen, Eija; Visakorpi, Tapio; Kallioniemi, Anne Cytometry, Vol. 16, Issue 2 https://doi.org/10.1002/cyto.990160202	journal	June 1994
Quantitative in situ hybridization reveals extent of sequence homology between related DNA sequences in Drosophila melanogaster Brock, Hugh W.; Roberts, David B. Chromosoma, Vol. 83, Issue 2 https://doi.org/10.1007/BF00286786	journal	July 1981
Characterization of chromosomal anomalies in human breast cancer Dutrillaux, Bernard; Gerbault-Seureau, Michele; Zafrani, Brigitte Cancer Genetics and Cytogenetics, Vol. 49, Issue 2 https://doi.org/10.1016/0165-4608(90)90143-X	journal	October 1990
The Use of the Avidin-Biotin Complex as a Tool in Molecular Biology Bayer, Edward A.; Wilchek, Meir Methods of Biochemical Analysis, Volume 26 https://doi.org/10.1002/9780470110461.ch1	book	February 1980
Bi-color detection of two target DNAs by non-radioactive in situ hybridization Hopman, A. H. N.; Wiegant, J.; Raap, A. K. Histochemistry, Vol. 85, Issue 1 https://doi.org/10.1007/BF00508646	journal	January 1986
Fluorescence In Situ Hybridization in Cancer and Radiation Biology Gray, Joe W.; Pinkel, Daniel; Brown, J. Martin Radiation Research, Vol. 137, Issue 3 https://doi.org/10.2307/3578700	journal	March 1994
New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile Ruault, Myriam; van der Bruggen, Pierre; Brun, Marie-Elisabeth European Journal of Human Genetics, Vol. 10, Issue 12 https://doi.org/10.1038/sj.ejhg.5200891	journal	December 2002
Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia Le Beau, Michelle M.; Westbrook, Carol A.; Diaz, Manuel O. Nature, Vol. 316, Issue 6031 https://doi.org/10.1038/316826a0	journal	August 1985
The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA Lawn, Richard M.; Fritsch, Edward F.; Parker, Richard C. Cell, Vol. 15, Issue 4 https://doi.org/10.1016/0092-8674(78)90043-0	journal	December 1978
Fish technology in chromosome and genome research Heng, Henry H. Q.; Spyropoulos, Barbara; Moens, Peter B. BioEssays, Vol. 19, Issue 1 https://doi.org/10.1002/bies.950190112	journal	January 1997
In Situ Hybridization to Cellular RNAs Angerer, R. C.; Cox, K. H.; Angerer, L. M. Genetic Engineering: Principles and Methods https://doi.org/10.1007/978-1-4684-4973-0_3	book	January 1985
Feasibility of in situ hybridisation with chromosome specific DNA probes on paraffin wax embedded tissue. Arnoldus, E. P.; Dreef, E. J.; Noordermeer, I. A. Journal of Clinical Pathology, Vol. 44, Issue 11 https://doi.org/10.1136/jcp.44.11.900	journal	November 1991
Proto-oncogene amplification and homogeneously staining regions in human breast carcinomas Saint-Ruf, Claude; Gerbault-Seureau, Michéle; Viegas-Péquignot, Evani Genes, Chromosomes and Cancer, Vol. 2, Issue 1 https://doi.org/10.1002/gcc.2870020105	journal	May 1990
Use of DNA and Peptide Nucleic Acid Molecular Beacons for Detection and Quantification of rRNA in Solution and in Whole Cells Xi, Chuanwu; Balberg, Michal; Boppart, Stephen A. Applied and Environmental Microbiology, Vol. 69, Issue 9 https://doi.org/10.1128/AEM.69.9.5673-5678.2003	journal	September 2003
Localization of sequences specifying messenger RNA to light-staining G-bands of human chromosomes Yunis, J�rge J.; Kuo, Macus Tien; Saunders, Grady F. Chromosoma, Vol. 61, Issue 4 https://doi.org/10.1007/BF00288617	journal	January 1977
The activity of two heat shock loci of Drosophila hydei in tissue culture cells and salivary gland cells as analyzed by in situ hybridization of complementary DNA Sondermeijer, P. J. A.; Lubsen, N. H. Chromosoma, Vol. 72, Issue 3 https://doi.org/10.1007/BF00331090	journal	January 1979
Electron microscopic visualization of tRNA genes with ferritin-avidin: biotin labels Broker, Thomas R.; Angerer, Lynne M.; Yen, Pauline H. Nucleic Acids Research, Vol. 5, Issue 2 https://doi.org/10.1093/nar/5.2.363	journal	January 1978
The synthesis of oligonucleotides containing an aliphatic amino group at the 5′ terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis Smith, Lloyd M.; Fung, Steven; Hunkapiller, Michael W. Nucleic Acids Research, Vol. 13, Issue 7 https://doi.org/10.1093/nar/13.7.2399	journal	January 1985
Amplified sequences from chromosome 15, including centromeres, nucleolar organizer regions, and centromeric heterochromatin, in homogeneously staining regions in the human melanoma cell line MeWo Holden, J. J. A.; Reimer, D. L.; Higgins, M. J. Cancer Genetics and Cytogenetics, Vol. 14, Issue 1-2 https://doi.org/10.1016/0165-4608(85)90224-9	journal	January 1985
Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes Brigati, David J.; Myerson, David; Leary, Jeffry J. Virology, Vol. 126, Issue 1 https://doi.org/10.1016/0042-6822(83)90460-9	journal	April 1983
Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors Kallioniemi, A.; Kallioniemi, O.; Sudar, D. Science, Vol. 258, Issue 5083 https://doi.org/10.1126/science.1359641	journal	October 1992
Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy. Ried, T.; Baldini, A.; Rand, T. C. Proceedings of the National Academy of Sciences, Vol. 89, Issue 4 https://doi.org/10.1073/pnas.89.4.1388	journal	February 1992
An extra segment in chromosome 1 of wild Mus musculus: a C-band positive homogeneously staining region Traut, W.; Winking, H.; Adolph, S. Cytogenetic and Genome Research, Vol. 38, Issue 4 https://doi.org/10.1159/000132077	journal	January 1984
Detection of two viral genomes in single cells by double-label hybridization in situ and color microradioautography Haase, A.; Walker, D.; Stowring, L. Science, Vol. 227, Issue 4683 https://doi.org/10.1126/science.2981430	journal	January 1985
Localization of a unique gene by direct hybridization in situ. Gerhard, D. S.; Kawasaki, E. S.; Bancroft, F. C. Proceedings of the National Academy of Sciences, Vol. 78, Issue 6 https://doi.org/10.1073/pnas.78.6.3755	journal	June 1981
Quantitation of in situ hybridization of ribosomal ribonucleic acids to human diploid cells Cot�, Babette D.; Uhlenbeck, Olke C.; Steffensen, Dale M. Chromosoma, Vol. 80, Issue 3 https://doi.org/10.1007/BF00292689	journal	October 1980
Organization and chromosomal specificity of autosomal homologs of human Y chromosome repeated DNA Burk, Robert D.; Szabo, Paul; O'Brien, Steve Chromosoma, Vol. 92, Issue 3 https://doi.org/10.1007/BF00348698	journal	January 1985
Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future Ray, Arghya; Nordén, Bengt The FASEB Journal, Vol. 14, Issue 9 https://doi.org/10.1096/fasebj.14.9.1041	journal	June 2000
Detection of a human chromosomal translocation t(8;9) in a baby with multiple malformations using two-color fluorescence in situ hybridization Sasaki, Kohsuke; Pinkel, Daniel; Tsukahara, Masato Pathology International, Vol. 44, Issue 2 https://doi.org/10.1111/j.1440-1827.1994.tb01699.x	journal	February 1994
A polymorphic locus on the long arm of chromosome 20 defined by two probes from a single cosmid Litt, M.; Sheehy, R.; Bruns, G. A. Human Genetics, Vol. 73, Issue 4 https://doi.org/10.1007/BF00279097	journal	August 1986
Cytogenetic Analysis by In Situ Hybridization with Fluorescently Labeled Nucleic Acid Probes Pinkel, D.; Gray, J. W.; Trask, B. Cold Spring Harbor Symposia on Quantitative Biology, Vol. 51, Issue 0 https://doi.org/10.1101/SQB.1986.051.01.018	journal	January 1986
2-Acetylaminofluorene-modified probes for the indirect hybridocytochemical detection of specific nucleic acid sequences Landegent, J. E.; De Wal, N. Jansen In; Baan, R. A. Experimental Cell Research, Vol. 153, Issue 1 https://doi.org/10.1016/0014-4827(84)90448-8	journal	July 1984
A new era in mammalian gene mapping: somatic cell genetics and recombinant DNA methodologies Ruddle, F. H. Nature, Vol. 294, Issue 5837 https://doi.org/10.1038/294115a0	journal	November 1981
A highly polymorphic locus in human DNA revealed by cosmid-derived probes. Litt, M.; White, R. L. Proceedings of the National Academy of Sciences, Vol. 82, Issue 18 https://doi.org/10.1073/pnas.82.18.6206	journal	September 1985
Biotin and fluorescent labeling of RNA using T4 RNA ligase Richardson, Ross W.; Gumport, Richard I. Nucleic Acids Research, Vol. 11, Issue 18 https://doi.org/10.1093/nar/11.18.6167	journal	January 1983
Three-color fluorescence in situ hybridization for the simultaneous detection of multiple nucleic acid sequences Nederlof, P. M.; Robinson, D.; Abuknesha, R. Cytometry, Vol. 10, Issue 1 https://doi.org/10.1002/cyto.990100105	journal	January 1989
In Situ Detection of Supernumerary Aberrations of Chromosome-Specific Repetitive DNA Targets in Interphase Nuclei in Human Melanoma Cell Lines and Tissue Sections de Wit, Peter E. J.; Hopman, Anton H. N.; van Muijen, Goos N. P. Journal of Investigative Dermatology, Vol. 98, Issue 4 https://doi.org/10.1111/1523-1747.ep12499853	journal	April 1992
Construction and characterization of genomic libraries from specific human chromosomes. Krumlauf, R.; Jeanpierre, M.; Young, B. D. Proceedings of the National Academy of Sciences, Vol. 79, Issue 9 https://doi.org/10.1073/pnas.79.9.2971	journal	May 1982
Cytogenetic and molecular analysis in Philadelphia negative CML van der Plas, Dc; Hermans, Ab; Soekarman, D. Blood, Vol. 73, Issue 4 https://doi.org/10.1182/blood.V73.4.1038.1038	journal	March 1989

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