skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Uses of monoclonal antibody 8H9

Patent ·
OSTI ID:1176377

This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.

Research Organization:
Sloan-Kettering Institute for Cancer Research, New York, NY (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-93ER61658
Assignee:
Sloan-Kettering Institute for Cancer Research (New York, NY)
Patent Number(s):
7,740,845
Application Number:
10/505,658
OSTI ID:
1176377
Resource Relation:
Patent File Date: 2003 Mar 06
Country of Publication:
United States
Language:
English

References (199)

Secretion of a single-gene-encoded immunoglobulin from myeloma cells. journal September 1993
Novel tumor target for antibody-based therapy of rhabdomyosarcoma and other pediatric solid tumors journal January 2000
Surface Antigen Expression and Complement Susceptibility of Differentiated Neuroblastoma Clones journal March 2000
A Phase I/IB trial of murine monoclonal anti-GD2 antibody 14.G2a plus interleukin-2 in children with refractory neuroblastoma journal July 1997
Improved Gene Transfer into Human Lymphocytes Using Retroviruses with the Gibbon Ape Leukemia Virus Envelope journal August 1996
SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2 journal January 1994
Desmoplastic Small Round Cell Tumor: II: An Ultrastructural and Immunohistochemical Study with Emphasis on New Immunohistochemical Markers journal January 1998
Gamma Camera Dual Imaging with a Somatostatin Receptor and Thymidine Kinase after Gene Transfer with a Bicistronic Adenovirus in Mice journal May 2002
GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma journal May 1989
Complete Tumor Ablation With Iodine 131-Radiolabeled Disialoganglioside GD2-Specific Monoclonal Antibody Against Human Neuroblastoma Xenografted in Nude Mice23 journal September 1986
Autologous stem cell transplantation for solid tumors in children journal January 1997
Monoclonal antibody ONS-M21 recognizes integrin α3 in gliomas and medulloblastomas journal December 1998
Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells journal July 1997
Expression of Somatostatin Receptor Subtype 2 mRNA in Human Lymphoid Cells journal October 1997
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. journal September 1979
Anti-G(D2) antibody treatment of minimal residual stage 4 neuroblastoma diagnosed at more than 1 year of age. journal September 1998
Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor. Induction of efficient antibody-mediated antitumor cytotoxicity not detected by isotope release assays journal August 1989
Rapid selection of antigen-specific T lymphocytes by retroviral transduction journal July 2000
Ga-66 labeled somatostatin analogue DOTA-DPhe 1 -Tyr 3 -octreotide as a potential agent for positron emission tomography imaging and receptor mediated internal radiotherapy of somatostatin receptor positive tumors journal February 2002
Continuous cultures of fused cells secreting antibody of predefined specificity journal August 1975
Implementation of a Monte Carlo dosimetry method for patient-specific internal emitter therapy journal July 1997
Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immmunotherapy journal June 1997
Desmoplastic small round-cell tumor: prolonged progression-free survival with aggressive multimodality therapy. journal May 1996
A Monte Carlo approach to patient-specific dosimetry journal September 1996
Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells. journal May 1994
Experimental Tumor Therapy in Mice Using the Cyclophosphamide-Activating Cytochrome P450 2B1 Gene journal August 1994
High-Efficiency Gene Transfer into Normal and Adenosine Deaminase-Deficient T Lymphocytes Is Mediated by Transduction on Recombinant Fibronectin Fragments journal January 1998
Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient? journal January 1984
Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells journal July 1994
Tumor localization of adoptively transferred indium-111 labeled tumor infiltrating lymphocytes in patients with metastatic melanoma. journal February 1989
MicroRNA miR-29 Modulates Expression of Immunoinhibitory Molecule B7-H3: Potential Implications for Immune Based Therapy of Human Solid Tumors journal July 2009
Impact of chimeric immune receptor extracellular protein domains on T cell function journal March 1999
Tyrosine kinase chimeras for antigen-selective T-body therapy journal April 1998
Barriers to Drug Delivery in Solid Tumors journal July 1994
Myogenin is a Specific Marker for Rhabdomyosarcoma: An Immunohistochemical Study in Paraffin-Embedded Tissues journal September 2000
Detection of Prostatic Specific Membrane Antigen Messenger RNA Using Immunobead Reverse Transcriptase Polymerase Chain Reaction journal January 1999
Hexabrachion Protein (Tenascin, Cytotactin, Brachionectin) in Connective Tissues, Embryonic Brain, and Tumors journal January 1988
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors journal June 1992
The curability of tumours of differing size by targeted radiotherapy using 131I or 90Y journal June 1991
Common Musculoskeletal Tumors of Childhood and Adolescence journal July 1999
Radioimmunotherapy with alpha-emitting nuclides journal September 1998
Rhabdomyosarcoma journal August 1997
Phase I trial of murine monoclonal antibody 14G2a administered by prolonged intravenous infusion in patients with neuroectodermal tumors. journal January 1994
Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome journal March 1999
Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulating factor journal July 1990
3F8 monoclonal antibody treatment of patients with stage 4 neuroblastoma: a phase II study. journal June 1998
Detection of (11; 22)(q24;q12) Translocation-Bearing Cells in Peripheral Blood Progenitor Cells of Patients With Ewing's Sarcoma Family of Tumors journal March 1995
Extended-cycle elutriation to adjust T-cell content in HLA-disparate bone marrow transplantation journal July 1993
Mammalian expression of single chain variable region fragments dimerized by Fc regions journal January 1995
Production of a Single-Chain Fragment of the Murine Anti-Idiotypic Antibody ACA125 as Phage-Displayed and Soluble Antibody by Recombinant Phage Antibody Technique journal February 1997
Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones journal July 1992
Single‐chain Fvs journal January 1995
Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants. journal September 1998
The Diagnostic Utility of Desmin: A Study of 584 Cases and Review of the Literature journal March 1990
Characterisation of a new mouse monoclonal antibody (ONS-M21) reactive with both medulloblastomas and gliomas journal November 1993
Pharmacokinetics of anti-ganglioside GD2 mAb 14G2a in a phase I trial in pediatric cancer patients journal January 1995
Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor journal October 1995
Role of High-Dose Chemotherapy With Hematopoietic Stem Cell Rescue in the Treatment of Metastatic or Recurrent Rhabdomyosarcoma journal January 2001
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes journal March 2003
Specific Lysis of Melanoma Cells by Receptor Grafted T Cells is Enhanced by Anti-Idiotypic Monoclonal Antibodies Directed to the scFv Domain of the Receptor journal May 1999
Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: selection of specific antibodies from single-chain Fv fusion phage libraries. journal July 1995
Total-body irradiation and autologous bone marrow transplant in the treatment of high-risk Ewing's sarcoma and rhabdomyosarcoma. journal October 1993
Phase I trial of the chimeric anti-GD2 monoclonal antibody ch14.18 in patients with malignant melanoma journal March 1992
Anti-Tumor Activity of Human T Cells Expressing the CC49-zeta Chimeric Immune Receptor journal January 1999
CANCER MODELS: Systems for Identifying New Drugs Are Often Faulty journal November 1997
Anti-Idiotypic Antibody as the Surrogate Antigen for Cloning scFv and its Fusion Proteins journal December 2002
Single-chain antigen-binding proteins journal October 1988
A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone journal April 1987
Human Glioma-Specific Antigens Detected by Monoclonal Antibodies journal January 1992
Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor. journal February 1997
Targeting of tumor cells by lymphocytes engineered to express chimeric receptor genes journal May 2004
Single-chain antibody streptavidin fusions: Tetrameric bifunctional scFv-complexes with biotin binding activity and enhanced affinity to antigen journal September 1995
Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 scid/scid mice. journal March 1996
Disialoganglioside GD2 and a novel tumor antigen: Potential targets for immunotherapy of desmoplastic small round cell tumor journal October 2002
Clinical Applications of CD34 + Peripheral Blood Progenitor Cells (PBPC) journal March 2000
Treatment of Patients With Low-Grade B-Cell Lymphoma With the Combination of Chimeric Anti-CD20 Monoclonal Antibody and CHOP Chemotherapy journal January 1999
Autologous stem cell transplantation for high-risk pediatric solid tumors journal September 1999
An optimized method for cell-based phage display panning journal March 1997
Efficient Discrimination between Different Densities of Target Antigen by Tetracycline-Regulatable T Bodies journal March 1999
Factors Regulating the Cytotoxic Activity of the Human Natural Killer Cell Line, NK-92 journal June 2001
A recombinant antibody-interleukin 2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice. journal September 1994
Immunological Responses to the Tumor-Associated Antigen CA15 in Patients with Advanced Ovarian Cancer Induced by the Murine Monoclonal Anti-idiotype Vaccine ACA125 journal February 1997
Phase I studies of treatment of malignant gliomas and neoplastic meningitis with131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab?)2-a preliminary report journal January 1995
Targeting of small-cell lung cancer using the anti-GD2 ganglioside monoclonal antibody 3F8: A pilot trial journal February 1996
Radionuclide photon dose kernels for internal emitter dosimetry journal May 1996
A phase I study of human/mouse chimeric antiganglioside GD2 antibody ch14.18 in patients with neuroblastoma journal January 1995
A surrogate hepatitis B virus antigenic epitope represented by a synthetic peptide and an internal image antiidiotype antibody. journal July 1986
Multimodality Diagnostics and Megatherapy in Poor Prognosis Ewing's Tumor Patients journal October 1999
Radiotherapy and High-Dose Chemotherapy in Advanced Ewing's Tumors journal October 1999
Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukaemia patients using real-time quantitative RT-PCR: Monitoring of MRD by Real-time Quantitation journal August 1998
T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients journal February 1996
CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: Implications for cellular immunotherapy of CD20+ malignancy journal August 1998
Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, phase III trial. The Immunomedics Study Group. journal August 1996
Flow cytometric assessment of human MIC2 expression in bone marrow, thymus, and peripheral blood journal January 1994
Immunomagnetic Purging of Ewing’s Sarcoma From Blood and Bone Marrow: Quantitation by Real-Time Polymerase Chain Reaction journal August 2001
RT-PCR evaluation of peripheral blood, bone marrow and peripheral blood stem cells in children and adolescents undergoing VACIME chemotherapy for Ewing’s sarcoma and alveolar rhabdomyosarcoma journal September 1999
Diganglioside GD2 and Antigen 8H9: Potential Targets for Antibody-Based Immunotherapy against Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma journal April 1999
Intra-abdominal desmoplastic small cell tumor: A light microscopic, immunocytochemical, ultrastructural, and flow cytometric study journal August 1993
Expression of HER2/ erb B-2 Correlates With Survival in Osteosarcoma journal September 1999
New monoclonal antibodies specific for human sarcomas journal July 1986
HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia journal June 1997
Effect of glycosylation on antibody function: implications for genetic engineering journal January 1997
IDEC-C2B8: results of a phase I multiple-dose trial in patients with relapsed non-Hodgkin's lymphoma. journal October 1997
High-dose sequential chemotherapy and autologous stem cell reinfusion in advanced pediatric solid tumors journal December 1997
Targeting of GD2-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes journal January 2001
Ganglioside GD2 specific monoclonal antibody 3F8: a phase I study in patients with neuroblastoma and malignant melanoma. journal September 1987
Immunocytokines: A Promising Approach to Cancer Immunotherapy journal December 1998
Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition journal June 1997
Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes. journal March 1994
In Vitro and in Vivo Cytotoxic Activities of Recombinant Immunotoxin 8H9(Fv)-PE38 against Breast Cancer, Osteosarcoma, and Neuroblastoma journal February 2004
Man-made antibodies journal January 1991
Monoclonal antibody against ependymoma-derived cell line journal January 1992
Anti-Idiotypic Antibody Facilitates scFv Chimeric Immune Receptor Gene Transduction and Clonal Expansion of Human Lymphocytes for Tumor Therapy journal August 2003
Reassessment of patient response to monoclonal antibody 3F8. journal April 1992
Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin γ1 Fc or CH3 region journal July 1999
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease journal November 1979
Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors journal October 1996
Characteristics of the cell surface antigen, p72, associated with a variety of human tumours and mitogen-stimulated T-lymphoblasts journal June 1984
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. journal August 1988
Treatment of recurrent and cystic malignant gliomas by a single intracavity injection of 131I monoclonal antibody: feasibility, pharmacokinetics and dosimetry journal January 1993
Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing’s sarcoma journal November 1998
Pharmacokinetics and acute toxicology of intraventricular 131I-monoclonal antibody targeting disialoganglioside in non-human primates journal January 1997
In vitro and in vivo characterisation of a recombinant carboxypeptidase G2::anti-CEA scFv fusion protein journal February 1996
Use of Reverse Transcriptase Polymerase Chain Reaction for Diagnosis and Staging of Alveolar Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, and Desmoplastic Small Round Cell Tumor journal January 2001
An alternating selection strategy for cloning phage display antibodies journal August 1999
Gene-marking to trace origin of relapse after autologous bone-marrow transplantation journal January 1993
Selection of scFv Phages on Intact Cells Under Low pH Conditions Leads to a Significant Loss of Insert-Free Phages journal February 2001
Presence of tumor cells in bone marrow but not in blood is associated with adverse prognosis in patients with Ewing's tumor. Société Française d'Oncologie Pédiatrique. journal May 1998
Biotechnological and gene therapeutic strategies in cancer treatment journal June 1995
High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes. journal August 1995
Comparison of three different methods for radiolabelling human activated T lymphocytes journal May 1997
131I Radioconjugated Antibodies for the Locoregional Radioimmunotherapy of High-grade Malignant Glioma: Phase I and II Study journal January 1999
Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes journal August 1998
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. journal January 1993
Demonstration of accuracy and clinical versatility of mutual information for automatic multimodality image fusion using affine and thin-plate spline warped geometric deformations journal April 1997
Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR journal November 1999
Superantigen-staphylococal-enterotoxin-A-dependent and antibody-targeted lysis of GD2-positive neuroblastoma cells journal March 1995
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor journal January 2002
Yttrium-90 biodistribution by yttrium-87 imaging: A theoretical feasibility analysis journal August 1998
Human single-chain Fv immunoconjugates targeted to a melanoma-associated chondroitin sulfate proteoglycan mediate specific lysis of human melanoma cells by natural killer cells and complement journal February 1999
Decay-accelerating factor protects human tumor cells from complement-mediated cytotoxicity in vitro. journal April 1988
Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain journal July 1993
Targeting Tumor Specific Translocations in Sarcomas in Pediatric Patients for Immunotherapy journal January 2000
Low incidence of molecular evidence for tumour in PBPC harvests from patients with high risk Ewing tumours journal August 1999
Disialoganglioside GD2 anti-idiotypic monoclonal antibodies journal May 1993
Expression of CD44 splice variants in human primary brain tumors journal December 1995
In vivo tracking of tumor-specific T cells journal April 2001
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 journal August 1970
Physical barriers to drug delivery in tumors journal February 1993
Radioimmunolocalisation of human brain tumours: Biodistribution of radiolabelled monoclonal antibody UJ13A journal October 1986
Expression of 300-kilodalton intermediate filament-associated protein distinguishes human glioma cells from normal astrocytes. journal September 1993
Comparison of purity and enrichment of CD34 + cells from bone marrow, umbilical cord and peripheral blood (primed for apheresis) using five separation systems journal January 1995
Quantitative imaging of I-124 using positron emission tomography with applications to radioimmunodiagnosis and radioimmunotherapy: Quantitative imaging of I-124 journal May 1991
Development of a method to measure kinetics of radiolabelled monoclonal antibody in human tumour with applications to microdosimetry: positron emission tomography studies of iodine-124 labelled 3F8 monoclonal antibody in glioma journal May 1993
Ewing Family Tumors: Potential Prognostic Value of Reverse-Transcriptase Polymerase Chain Reaction Detection of Minimal Residual Disease in Peripheral Blood Samples journal January 1998
Radioimmunotherapy: recent results and future directions. journal April 1996
Cellular Immunotherapy of Malignancies Using the Clonal Natural Killer Cell Line NK-92 journal August 2001
Radioimmunotargeting of Human Rhabdomyosarcoma Using Monoclonal Antibody 8H9 journal October 2005
Diagnostic imaging of human neuroblastoma with radiolabeled antibody. journal November 1986
Intra-abdominal Desmoplastic Small Round-Cell Tumor: Report of 19 Cases of a Distinctive Type of High-Grade Polyphenotypic Malignancy Affecting Young Individuals journal January 1991
A potent and specific immunotoxin for tumor cells expressing disialoganglioside GD2 journal May 1991
Adoptive cellular immunotherapy for EBV lymphoproliferative diseases journal June 1997
Intraparenchymal and Intratumoral Interstitial Infusion of Anti-Glioma Monoclonal Antibody 8h9 journal December 2008
Functional expression of chimeric receptor genes in human T cells journal February 2001
Phase I and Pharmacokinetic Trial of Oral Irinotecan Administered Daily for 5 Days Every 3 Weeks in Patients With Solid Tumors journal February 1999
Making Antibodies by Phage Display Technology journal April 1994
Phage Library-derived Human Anti-TETA and Anti-DOTA ScFv for Pretargeting RIT journal February 1999
Absolute requirement of CD11/CD18 adhesion molecules, FcRII and the phosphatidylinositol-linked FcRIII for monoclonal antibody-mediated neutrophil antihuman tumor cytotoxicity journal March 1992
Cloning of the Human Sodium Iodide Symporter journal September 1996
Human Antibodies from Combinatorial Libraries book January 1994
Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics journal December 1999
A phase I study of neuroblastoma with the anti-ganglioside GD2 antibody 14.G2a journal May 1992
Intergroup Rhabdomyosarcoma Study: Update for Pathologists journal November 1998
Comparison of the targeting characteristics of various radioimmunoconjugates for radioimmunotherapy of neuroblastoma: Dosimetry calculations incorporating cross-organ beta doses journal January 1996
Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma. journal June 1998
Progress in the Diagnosis and Treatment of Rhabdomyosarcoma and Related Soft Tissue Sarcomas journal January 2000
Detection of metastatic neuroblastoma in bone marrow: when is routine marrow histology insensitive? journal August 1997
Immunohistochemical Profile of Monoclonal Antibody 013: Antibody That Recognizes Glycoprotein p30/32MIC2 and is Useful in Diagnosing Ewingʼs Sarcoma and Peripheral Neuroepithelioma journal January 1994
Monoclonal antibody against human glioblastoma multiforme (U-87MG) immunoprecipitates a protein of molecular mass 38 kDa and inhibits tumor growth in nude mice journal January 1995
Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes journal December 1998
A TNF receptor antagonistic scFv, which is not secreted in mammalian cells, is expressed as a soluble mono- and bivalent scFv derivative in insect cells journal October 1997
Isolation of single chain antibody fragments with specificity for cell surface antigens by phage display utilizing internal image anti-idiotypic antibodies journal September 1998
Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers journal February 1996
Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity journal February 1999
CD34+ selection of autologous peripheral blood stem cells for transplantation following sequential cycles of high-dose therapy and mobilisation in multiple myeloma journal June 2000
Applications of monoclonal antibodies in clinical oncology journal December 1994
The Third Intergroup Rhabdomyosarcoma Study. journal March 1995
Novel Tumor-Associated Surface Antigen: Broad Distribution among Neuroectodermal, Mesenchymal and Epithelial Tumors, with Restricted Expression among Normal Tissues † 785 journal April 1998
A humanized antibody that binds to the interleukin 2 receptor. journal December 1989
Potential of genetically engineered anti-ganglioside GD2 antibodies for cancer immunotherapy book January 1994
Title>Additive cytotoxicity of different monoclonal antibody-cobra venom factor conjugates for human neuroblastoma cells journal November 1997
The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour journal November 1997
Occurrence of ganglioside GD3 in neoplastic astrocytes journal March 1999
Production and characterization of human monoclonal anti-idiotype antibodies to anti-dsDNA antibodies journal June 2002
Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes journal May 1996
A new class of antigen-specific killer cells journal January 1997
Phase Ia/Ib Trial of Anti-GD2 Chimeric Monoclonal Antibody 14.18 (ch l4.18) and Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhGM-CSF) in Metastatic Melanoma journal January 1996
Monoclonal antibody-based therapy for neuroblastoma journal December 2000
Myeloablative radiochemotherapy and hematopoietic stem-cell rescue in poor-prognosis Ewing's sarcoma. journal August 1993

Similar Records

Uses of monoclonal antibody 8H9
Patent · Tue Apr 10 00:00:00 EDT 2018 · OSTI ID:1176377

Uses of monoclonal antibody 8H9
Patent · Tue Aug 06 00:00:00 EDT 2013 · OSTI ID:1176377

Uses of monoclonal antibody 8H9
Patent · Tue Jun 15 00:00:00 EDT 2010 · OSTI ID:1176377