Compositions and methods related to serotonin 5-HT1A receptors

Patent · Tue Jun 08 00:00:00 EDT 2010

OSTI ID:1176335

Mukherjee, Jogeshwar; Saigal, Neil

Contemplated substituted arylpiperazinyl compounds, and most preferably ¹⁸F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with ¹⁸F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.

• Research Organization: Univ. of California, Oakland, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: FG03-02ER63294
• Assignee: The Regents of the University of California (Oakland, CA)
• Patent Number(s): 7,731,940
• Application Number: 11/626,797
• OSTI ID: 1176335
• Resource Relation: Patent File Date: 2007 Jan 24
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
60 APPLIED LIFE SCIENCES