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Title: Synthesis of 3'-, or 5'-, or internal methacrylamido-modified oligonucleotides

Abstract

New modifiers were synthesized for incorporation of a methacrylic function in 3'-, 5'- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of 5'-methacrylated oligonucleotides for preparation of microarrays by a co-polymerization method.

Inventors:
;
Publication Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176258
Patent Number(s):
7,705,136
Application Number:
11/066,791
Assignee:
UChicago Argonne, LLC (Chicago, IL)
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Golova, Julia B., and Chernov, Boris K. Synthesis of 3'-, or 5'-, or internal methacrylamido-modified oligonucleotides. United States: N. p., 2010. Web.
Golova, Julia B., & Chernov, Boris K. Synthesis of 3'-, or 5'-, or internal methacrylamido-modified oligonucleotides. United States.
Golova, Julia B., and Chernov, Boris K. 2010. "Synthesis of 3'-, or 5'-, or internal methacrylamido-modified oligonucleotides". United States. https://www.osti.gov/servlets/purl/1176258.
@article{osti_1176258,
title = {Synthesis of 3'-, or 5'-, or internal methacrylamido-modified oligonucleotides},
author = {Golova, Julia B. and Chernov, Boris K.},
abstractNote = {New modifiers were synthesized for incorporation of a methacrylic function in 3'-, 5'- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of 5'-methacrylated oligonucleotides for preparation of microarrays by a co-polymerization method.},
doi = {},
url = {https://www.osti.gov/biblio/1176258}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 27 00:00:00 EDT 2010},
month = {Tue Apr 27 00:00:00 EDT 2010}
}

Works referenced in this record:

Arrays in biological and chemical analysis
journal, February 2002


Immobilization of acrylamide-modified oligonucleotides by co-polymerization
journal, January 1999


Fabrication of Microarray of Gel-Immobilized Compounds on a Chip by Copolymerization
journal, September 1999


A novel linker for the solid-phase synthesis of a library of 3′-thiophosphorylated dinucleotides
journal, May 2001


Hydrogel drop microchips with immobilized DNA: properties and methods for large-scale production
journal, February 2004