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Title: High performance hybrid magnetic structure for biotechnology applications

Patent ·
OSTI ID:1176029

The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides for separation and other biotechnology applications involving holding, manipulation, or separation of magnetic or magnetizable molecular structures and targets. Also disclosed are: a method of assembling the hybrid magnetic plates, a high throughput protocol featuring the hybrid magnetic structure, and other embodiments of the ferromagnetic pole shape, attachment and adapter interfaces for adapting the use of the hybrid magnetic structure for use with liquid handling and other robots for use in high throughput processes.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,148,778
Application Number:
11/248,934
OSTI ID:
1176029
Resource Relation:
Patent File Date: 2005 Oct 11
Country of Publication:
United States
Language:
English

References (4)

High-Throughput Plasmid Purification for Capillary Sequencing journal July 2001
Calculation of magnetic error fields in hybrid insertion devices
  • Savoy, R.; Halbach, K.; Hassenzahl, W.
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 291, Issue 1-2 https://doi.org/10.1016/0168-9002(90)90095-N
journal May 1990
Use of Permanent Magnets in Accelerator Technology: Present and Future journal January 1987
Magnetic Bead Purification of Labeled DNA Fragments for High-Throughput Capillary Electrophoresis Sequencing journal June 2002