Functional nucleic acid probes and uses thereof

Nilsen-Hamilton, Marit

Title: Functional nucleic acid probes and uses thereof

Patent · Tue Oct 03 00:00:00 EDT 2006

OSTI ID:1175921

Nilsen-Hamilton, Marit

The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.

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Research Organization:: Iowa State Univ., Ames, IA (United States); Ames Laboratory (AMES), Ames, IA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-82

Assignee:: Iowa State University Research Foundation, Inc. (Ames, IA)

Patent Number(s):: 7,115,369

Application Number:: 10/096,872

OSTI ID:: 1175921

Resource Relation:: Patent File Date: 2002 Mar 14

Country of Publication:: United States

Language:: English

References (9)

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Structure, recognition and discrimination in RNA aptamer complexes with cofactors, amino acids, drugs and aminoglycoside antibiotics Patel, Dinshaw J.; Suri, Asif K. Reviews in Molecular Biotechnology, Vol. 74, Issue 1 https://doi.org/10.1016/S1389-0352(99)00003-3	journal	March 2000
Aptamers as therapeutic and diagnostic agents Brody, Edward N.; Gold, Larry Reviews in Molecular Biotechnology, Vol. 74, Issue 1 https://doi.org/10.1016/S1389-0352(99)00004-5	journal	March 2000

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