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Title: Antibody specific for a DNA repair protein

Patent ·
OSTI ID:1175830
; ; ;

An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

Research Organization:
Wisconsin Alumni Research Foundation, Madison, WI (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
4459-011502
Assignee:
Wisconsin Alumni Research Foundation
Patent Number(s):
7,074,902
Application Number:
10/044,447
OSTI ID:
1175830
Country of Publication:
United States
Language:
English

References (16)

Production of pharmaceutical proteins from transgenic animals journal May 1994
Targeting the mouse genome: a compendium of knockouts (part I) journal June 1995
Knockout Mice journal April 1996
Analysis of the 5′ Region ofPMS2Reveals Heterogeneous Transcripts and a Novel Overlapping Gene journal September 1995
Transgenic and knock-out models for studying DNA repair journal January 1995
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway journal April 2000
Monoclonal antibodies in cancer detection and therapy journal March 1993
hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. journal October 1997
Xpaknockout mice journal October 1996
Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. journal September 1996
Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells journal August 1997
Targeting the mouse genome: a compendium of knockouts (part II) journal July 1995
Isolation and Characterization of the Human MRE11 Homologue journal September 1995
Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome journal May 1998
Expression of RAD4 Gene of Saccharomyces cerevisiae That Can Be Propagated in Escherichia coli without Inactivation journal May 1993
Gene therapy - promises, problems and prospects journal September 1997

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Related Subjects

60 APPLIED LIFE SCIENCES