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Title: Oncoprotein protein kinase

Patent ·
OSTI ID:1175214
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An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Research Organization:
Univ. of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
86ER60429
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
6,846,644
Application Number:
09/861,098
OSTI ID:
1175214
Country of Publication:
United States
Language:
English

References (21)

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis journal July 2001
Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase journal March 1988
Induction of protooncogene c-jun by serum growth factors. journal November 1988
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. journal October 1994
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. journal November 1993
A central role for JNK in obesity and insulin resistance journal November 2002
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 journal December 1987
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF journal May 1991
Parallel signal processing among mammalian MAPKs journal March 1995
Induction of proto-oncogene JUN/AP-1 by serum and TPA journal August 1988
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain journal March 1994
Structure and chromosomal localization of the functional intronless human JUN protooncogene. journal December 1988
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase journal November 2001
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control journal July 1990
Targeting JNK for therapeutic benefit: from junk to gold? journal July 2003
DNA-binding activity of jun is increased through its interaction with Fos journal April 1990
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase journal February 1990
Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain. journal June 1992
Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts journal August 1988
Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. journal November 1981
Phosphorylation of c-jun mediated by MAP kinases journal October 1991

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59 BASIC BIOLOGICAL SCIENCES